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Nephrology Journal Club

@nephjc.bsky.social

2.7K followers 130 following 2.2K posts

A twice monthly nephrology journal club that used to meet on Twitter. Hashtag #NephJC www.nephjc.com

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Nephrology Journal Club @nephjc.bsky.social · 16d

It's that time of year again 🍂🍂🍂
The #NephJC Fall pledge drive.
Plese give if you are able to support our decades long mission of #FOAMed for all. #NephSky #MedSky
www.nephjc.com/news/2025/9/22/nephjc-fall-pledge-drive

NephJC 2025 Fall Pledge Drive — NephJC

Help keep NephJC a vital, original, and unbiased source of medical education.

www.nephjc.com

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Nephrology Journal Club @nephjc.bsky.social · 1d

Up next!

CKD & Protein: Is Your Diet a Solution or a Silent Stressor? 🥩🔍
On October 14, we're discussing protein diets and outcomes in CKD/ESRD which still remains an enigma. ☀️📚 #NephJC

pubmed.ncbi.nlm.nih.gov/40876553/

#Skytorial by @nephromommy-akshu.bsky.social
Akshaya's signing off 👋

A Skit we performed for Women In Nephrology (WIN-ICON) India conference at Chennai in Sep 2025.

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Nephrology Journal Club @nephjc.bsky.social · 1d

10/10
Final #NephJC thoughts 🤔💭

While the study was a success, it is still a harsh reality that there exist many barriers to even getting a transplant. Much work is needed to safely simplify the procedure and make being IS - free a reliable reality for all kidney transplant patients!
#NephJC

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Nephrology Journal Club @nephjc.bsky.social · 1d

9/10
I want more info: 👓📖

Please go through the insightful summary by Akshaya Jayachandran @nephromommy-akshu.bsky.social and Natalia Nombera @roxnonna23.bsky.social 🔖📖

🎨Beautiful visual abstract by Bogdan @thekidneywhisperer.bsky.social
#NephJC

www.nephjc.com/news/chimera...

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Nephrology Journal Club @nephjc.bsky.social · 1d

8/10
#NephJC Quote of the fortnight from @brianrifkin.bsky.social 💬
Immune tolerance is nice, but unpredictable and requires constant vigilance to prevent rejection.
Would modifying graft kidneys to make them less antigenic be a better bet?
#NdphJC

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Nephrology Journal Club @nephjc.bsky.social · 1d

7/10
Chat consensus? 🎬
Although the study shows that the MDR-101 regimen induces chimerism and functional immune tolerance in HLA-matched living donor KTRs leading to complete IS elimination, it is far from being widely applicable. It’s too costly and works only in highly HLA matched KTRs.
#NephJC

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Nephrology Journal Club @nephjc.bsky.social · 1d

6/10
Give me something clever to say 🤓

Here’s what caught my attention!
@kidneyboy.bsky.social comparing life on dialysis vs pig transplant 🐖+ IS vs Live donor transplant 🫘and IS free! Definitely stuff worthy of a sci-fi movie! 👽

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Nephrology Journal Club @nephjc.bsky.social · 1d

5/10
A figure paints 🖼️ 1000 words!
KDQOL-SF36 data showed huge improvement in Burden of Kidney Disease and Mental Health Composite Scores at two and three years when patients were off IS. This demonstrates that even low-dose IS negatively impacts patient quality of life. 🙆💊
#NephJC

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Nephrology Journal Club @nephjc.bsky.social · 1d

4/10
One post results 📊
75% (15/20) of KTRs achieved functional immune tolerance (IS-free for two years) using the mixed chimerism strategy with MDR-101💉
The study showed 100% patient/graft survival and zero GVHD cases over three years, with improved quality of life. 4/20 KTRs resumed IS. #NephJC

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Nephrology Journal Club @nephjc.bsky.social · 1d

3/10
One Post Methods 👩‍🏫
Phase 3, prospective, open-label, randomized, multicenter trial - USA/Canada. Included kidney transplant recipients (KTR) from a 2-haplotype HLA-matched, living donors.

Primary outcome - functional immune tolerance - staying off all IS for at least 24 months. 💊
#NephJC

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Nephrology Journal Club @nephjc.bsky.social · 1d

2/10
What’d I miss?
Transplant immunosuppression (IS) causes significant drug toxicities, infection, cancer risks & huge costs 💸. “Functional tolerance” is a state in which the recipient’s immune system accepts the graft without additional IS. It has remained the "Holy grail" of transplant! #NephJC

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Nephrology Journal Club @nephjc.bsky.social · 1d

1/10
Welcome to #TenPostNephJC
Last #NephJC we discussed tolerance induction in HLA matched 🫘 transplants with donor Hematopoietic stem cells (MDR-101).
Missed the Chimeri-chat? No worries - We’re quite “tolerant” to those who missed their IS(Informative Session)!

pubmed.ncbi.nlm.nih.gov/39922283/

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Reposted by Nephrology Journal Club

Cristina Popa @nephroseeker.medsky.social · 6d

From MDR-101 to the Vienna trials, the message is clear: pairing donor marrow with precise immune regulation can shift kidney transplant care from lifelong suppression toward true, engineered tolerance #nephjc #nephsky

www.nephjc.com/news/2025/30...

Immune tolerance in kidney transplantation: from first principles to clinical engineering — NephJC

A commentary putting the chimerism and immune tolerance in perspective

www.nephjc.com

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Nephrology Journal Club @nephjc.bsky.social · 7d

True getting ethical committee approval is hardest of all
#NephJC

Nephrology Journal Club @nephjc.bsky.social · 7d

yah always transplant is better than dialysis, even prevention is better than RRT
#NephJC

Nephrology Journal Club @nephjc.bsky.social · 7d

Yah always transplant is better than dialysis

Nephrology Journal Club @nephjc.bsky.social · 7d

IF we use in many he cost might come down till then its a research institute protocol having stem cell facility, in India IKDRC has it's own lab for stem cells
#NephJC

Nephrology Journal Club @nephjc.bsky.social · 7d

Its a million dollar question
#NehJC

Nephrology Journal Club @nephjc.bsky.social · 7d

With this, I am, Dr Saivani,@drsaivani.bsky.social, today's NephJC host, signing off to celebrate our great festival “vijayanavami” with my beautiful family,
Have a great day

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Nephrology Journal Club @nephjc.bsky.social · 7d

yah even the Mucor is an indicator that he is immunosupressed, but maintaining on the same since 2 years is great
#NephJC

Nephrology Journal Club @nephjc.bsky.social · 7d

Heartfelt gratitude to the mentors who guided us in this awesome work
Brian [email protected]...,
Pallavi Prasad@drpallavipras..., Christina@nephroseek..., Swapnil [email protected]...,

Nephrology Journal Club @nephjc.bsky.social · 7d

Remember to be kind! ☀️

If you have ever used any #NephJC blog/ visual abstract or listened to any @freelyfiltered.bsky.social podcast, please consider donating.

✨💖 You'll help us keep doing quality post-publishing review

NephJC 2025 Fall Pledge Drive — NephJC

Help keep NephJC a vital, original, and unbiased source of medical education.

www.nephjc.com

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Nephrology Journal Club @nephjc.bsky.social · 7d

May be presence of infection that too mucor itself is an indicator, he is over immunosuppressed, but he is lucky to maintain he same creat since 2 years

Nephrology Journal Club @nephjc.bsky.social · 7d

Extremely thankful to wonderful team for nice team work
Akshaya@nephromommy-...,Natalia Nombera [email protected]...,Bogdan Agavriloaei @thekidneywhisperer.bsky.social ,jeyakumar@jeyakumarm...

Nephrology Journal Club @nephjc.bsky.social · 7d

If you want to stay on top of #NephJC happenings, sign up for our once a week newsletter
www.nephjc.com/newsl...

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Nephrology Journal Club @nephjc.bsky.social · 7d

Yah we need another yardstick other than chimera percentage to withhold immunosuppression