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Reposted by Cristina Popa

Nephrology Journal Club @nephjc.bsky.social · 2d

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Welcome to #TenPostNephJC
Last #NephJC we discussed tolerance induction in HLA matched 🫘 transplants with donor Hematopoietic stem cells (MDR-101).
Missed the Chimeri-chat? No worries - We’re quite “tolerant” to those who missed their IS(Informative Session)!

pubmed.ncbi.nlm.nih.gov/39922283/

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Reposted by Cristina Popa

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 2d

TREGs get the @nobelprize.bsky.social

www.nobelprize.org/prizes/medic...

Immune tolerance back in the news

#NephSky #Transplant

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

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Reposted by Cristina Popa

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 7d

Also check out @hildabast.bsky.social post on PubMed alternatives

absolutelymaybe.plos.org/2025/02/14/w...

What if We Can't Rely on PubMed? - Absolutely Maybe

PubMed is incredibly reliable. And a lot depends on it. It’s an ecosystem built around MEDLINE, the steady feed of new publications…

absolutelymaybe.plos.org

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Cristina Popa @nephroseeker.medsky.social · 7d

From MDR-101 to the Vienna trials, the message is clear: pairing donor marrow with precise immune regulation can shift kidney transplant care from lifelong suppression toward true, engineered tolerance #nephjc #nephsky

www.nephjc.com/news/2025/30...

Immune tolerance in kidney transplantation: from first principles to clinical engineering — NephJC

A commentary putting the chimerism and immune tolerance in perspective

www.nephjc.com

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Cristina Popa @nephroseeker.medsky.social · 8d

For now, this is the type of chimerism that keeps me awake 😅 #nephjc

www.youtube.com/shorts/WMPRJ...

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Reposted by Cristina Popa

Nephrology Journal Club @nephjc.bsky.social · 8d

If you want to support #NephJC
🍂🍂🍂Contribute to our Fall Pledge Drive 💰and get some cool merch. We only function because of you and appreciate all your donations to our work.
www.nephjc.com

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Cristina Popa @nephroseeker.medsky.social · 8d

These are the specifications from the supplement. They only receive G-CFS and apheresis - guess it helped with harvesting various cells they further needed #nephjc

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Reposted by Cristina Popa

Nephrology Journal Club @nephjc.bsky.social · 8d

T1e:
Tacrolimus was withdrawn completely at 1 year post-transplant, only if at ≥6 months donor mixed hematopoietic chimerism (≥5% donor WBCs in whole blood) was achieved.

🎨 Infographic by @nephromommy-akshu.bsky.social & @nephroseeker.medsky.social #NephJC

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Cristina Popa @nephroseeker.medsky.social · 8d

There are case series reporting. We had a pt, from rural area, and didn't took her IS for a while (she didn't remember), didn't come to cotrols for about 2 years. We only found out he was not on IS, because her T0=0. Cr after 15 yrs of KTx= 1, 1 mg/dl #NephJC
pmc.ncbi.nlm.nih.gov/articles/PMC...

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Cristina Popa @nephroseeker.medsky.social · 8d

Welcome to #nephjc

Flirting GIF

giphy.com

Reposted by Cristina Popa

Nephrology Journal Club @nephjc.bsky.social · 8d

🎨 No olviden revisar la versión en español traducir por @dramiliflores.bsky.social #NephJC

Tolerancia inmunológica: ¿la quimera del trasplante renal? - El resumen visual — NephJC

¿Qué significa estar libre de inmunosupresión en el trasplante renal? Revisa el Resumen Visual por Bogdan Agavriloaei

www.nephjc.com

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Reposted by Cristina Popa

Nephrology Journal Club @nephjc.bsky.social · 8d

🎨Beautiful visual abstract by
Bogdan Agavriloaei @thekidneywhisperer.bsky.social #NephJC

Achieving immune tolerance by chimerism in kidney transplant — NephJC

Is getting immunosuppression-free a chimera in kidney transplant? Check out the visual abstract by Bogdan Agavriloaei

www.nephjc.com

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Cristina Popa @nephroseeker.medsky.social · 8d

Hi! I'm Cristina, nephrologist from 🇷🇴
No COI

😴4 am, back from vacation for less than 48h, a bit under the weather

Lurking to learn tonight #NephJC

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Cristina Popa @nephroseeker.medsky.social · 8d

Haha… how did I missed this?!

a cartoon character with a top hat and a cane has the words rethornical thinking below him

ALT: a cartoon character with a top hat and a cane has the words rethornical thinking below him

media.tenor.com

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Reposted by Cristina Popa

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 14d

A #NephJC Shorts on the latest ASI trial - BaxHTN, from @brianrifkin.bsky.social

www.nephjc.com/news/2025/9/...

(we already gave lorundrostat the full NephJC treatment, so this gets the short end of the stick ;-))

ASIs Advance: NephJC Shorts on BaxHTN — NephJC

A NephJC short on the latest baxdrostat trial

www.nephjc.com

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Reposted by Cristina Popa

Nephrology Journal Club @nephjc.bsky.social · 8d

⏰ One hour left until #NephJC chat

🎧If you want to hear more chimera stories, listen to this podcast episode.

🐲 Did you know that even the idea of a kidney transplant was inspired by chimera mythology?

Two Truths and a Lie: Xenotransplantation — NSMC Internship

Episode 19. Two Truths and a Lie…Xenotransplantation

www.nsmc.blog

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Reposted by Cristina Popa

Nephrology Journal Club @nephjc.bsky.social · 8d

Check out the VA by @thekidneywhisperer.bsky.social for tonite's #NephJC discussion on chimerism 🦁🐐🐍 in transplantation. #NephSky #MedSky
9/30/25 at 9 pm only on Bluesky
www.nephjc.com/news/2025/chimerism-kidney-trx

Achieving immune tolerance by chimerism in kidney transplant — NephJC

Is getting immunosuppression-free a chimera in kidney transplant? Check out the visual abstract by Bogdan Agavriloaei

www.nephjc.com

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Cristina Popa @nephroseeker.medsky.social · 9d

Any luck to see you at #ERA26 ? They look so nice and joyful 🤩

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Cristina Popa @nephroseeker.medsky.social · 9d

Thank you for your support 🙏😊

Reposted by Cristina Popa

Nephrology Journal Club @nephjc.bsky.social · 10d

Chimerism might just be the 🔑 to immune tolerance and ending the need for immunosuppression 🚫💊after transplantation 🫘.
Join the discussion 9/30/25 at 9 pm EST on Bluesky #NephSky #MedSky #NephJC
www.nephjc.com/news/chimera-tolerance-njqe334

Chimerism and Immune Tolerance: Can We Says Goodbye to Immunosuppression? — NephJC

This week, we will discuss the use of creating chimeras to induce immune tolerance and its potential to decrease or eliminate the need for immunosuppression in kidney transplant recipients.

www.nephjc.com

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Cristina Popa @nephroseeker.medsky.social · 10d

#NephJC is a labor of a passionate volunteer team that believes education should be accessible, no matter where you are from in the world.

Even if editorial team donates unlimited hours of sleep, there are still costs to cover 💸 (👇 blog)

😊 Be kind, help us to #NephItForward

#Medsky #Nephsky

Nephrology Journal Club @nephjc.bsky.social · 17d

It's that time of year again 🍂🍂🍂
The #NephJC Fall pledge drive.
Plese give if you are able to support our decades long mission of #FOAMed for all. #NephSky #MedSky
www.nephjc.com/news/2025/9/22/nephjc-fall-pledge-drive

NephJC 2025 Fall Pledge Drive — NephJC

Help keep NephJC a vital, original, and unbiased source of medical education.

www.nephjc.com

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Reposted by Cristina Popa

Joel Topf @kidneyboy.bsky.social · 13d

Now showing Sibeprenlimab VISIONARY Phase 3 trial. Presentation originally give at ERA #GlomCon

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Reposted by Cristina Popa

Joel Topf @kidneyboy.bsky.social · 13d

Next up Zigakibart in IgAN treated for 76 weeks.

Zigakibart is an April inhibitor (learned how to access the poster slides, so screen grabs rather than photos of the slides)

Title, methods, and table 1 demographics #GlomCon

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Reposted by Cristina Popa

Joel Topf @kidneyboy.bsky.social · 11d

I did a blog post about Apple's new Hypertension Detection System

pbfluids.com/2025/09/appl...

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Reposted by Cristina Popa

Swapnil Hiremath 🍁🇨🇦 @hswapnil.medsky.social · 11d

Another vitamin D trial in AKI this time, and it still does not do much 😏

TRAstonDrs @castltrastondrs.bsky.social · 11d

#Medsky🧪 #Immunosky #nephsky #publichealth the study found that treatment with either calcifediol or calcitriol did not significantly reduce #acutekidneyinjury (AKI) in critically ill adults, despite the activated forms of vitamin D upregulating relevant gene pathways.

JCI Insight - Randomized trial of activated vitamin D for acute kidney injury prevention in critically ill patients

insight.jci.org

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