Bruce Verchere
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bruceverchere.bsky.social
Bruce Verchere
@bruceverchere.bsky.social
Scientist / diabetes researcher at BC Children's Hospital and UBC; Director, Centre for Molecular Medicine and Therapeutics; Co-founder, Integrated Nanotherapeutics. Interested in islets, mentorship, wine, baseball (Mariners), golf, theatre...
Could amyloid play a protective role in autoimmunity? 🤔
An unexpected immunological twist with potential implications for type 1 diabetes. #T1D
Proud of this work from a great team! 4/N
January 14, 2026 at 7:19 AM
Instead, diabetes was delayed in NOD mice with beta cell transgenic or knock-in expression of amyloidogenic human IAPP. We think phagocytosis of human IAPP aggregates by antigen-presenting cells (islet macrophages and DCs) interferes with antigen presentation and T cell activation. 3/N
January 14, 2026 at 7:17 AM
This was a surprising finding. We predicted islet amyloid formed from human IAPP would accelerate diabetes in the NOD mouse, since it triggers islet inflammation, and islet amyloid (a pathological feature of type 2 diabetes) has been observed in some type 1 diabetic human pancreas. 2/N
January 14, 2026 at 7:17 AM
Sorry to hear this Dan
Incretin pioneer
December 29, 2025 at 9:27 PM
happy holidays DM!
December 25, 2025 at 6:18 AM
So sorry to hear this
Glen was a great scientist, colleague, friend
And always with a sense of humour
November 13, 2025 at 3:59 AM
2253 was final total. Slower than last year (3050). Was a slow start with the rain but got busy when the rain slowed around 7 pm. #treatcount2025
November 1, 2025 at 6:02 AM
5 kids already!
I don't think we will beet last year's record of 3050 with rain and baseball
October 31, 2025 at 11:15 PM
Thanks! We are ready!
5 already....
We have #Thriller and #BlueJays projecting www.cbc.ca/news/canada/...
Halloween candy prices in B.C. have increased more than 10% since last year | CBC News
Statistics Canada data shows confectionery items went up 11.9 per cent in B.C. in the last year.
www.cbc.ca
October 31, 2025 at 11:14 PM
MDPI journals... 🤔
October 30, 2025 at 8:15 AM
Congrats Meltem, that was an outstanding PhD defense!
Good luck in your next career steps!
August 15, 2025 at 2:11 AM
and can play anywhere!
April 20, 2025 at 5:41 PM