Could amyloid play a protective role in autoimmunity? 🤔
An unexpected immunological twist with potential implications for type 1 diabetes. #T1D
Proud of this work from a great team! 4/N

Instead, diabetes was delayed in NOD mice with beta cell transgenic or knock-in expression of amyloidogenic human IAPP. We think phagocytosis of human IAPP aggregates by antigen-presenting cells (islet macrophages and DCs) interferes with antigen presentation and T cell activation. 3/N

This was a surprising finding. We predicted islet amyloid formed from human IAPP would accelerate diabetes in the NOD mouse, since it triggers islet inflammation, and islet amyloid (a pathological feature of type 2 diabetes) has been observed in some type 1 diabetic human pancreas. 2/N

Sorry to hear this Dan
Incretin pioneer

happy holidays DM!

So sorry to hear this
Glen was a great scientist, colleague, friend
And always with a sense of humour

2253 was final total. Slower than last year (3050). Was a slow start with the rain but got busy when the rain slowed around 7 pm. #treatcount2025

5 kids already!
I don't think we will beet last year's record of 3050 with rain and baseball

Thanks! We are ready!
5 already....
We have #Thriller and #BlueJays projecting www.cbc.ca/news/canada/...

MDPI journals... 🤔

Congrats Meltem, that was an outstanding PhD defense!
Good luck in your next career steps!

and can play anywhere!