Bruce Verchere
@bruceverchere.bsky.social
Scientist / diabetes researcher at BC Children's Hospital and UBC; Director, Centre for Molecular Medicine and Therapeutics; Co-founder, Integrated Nanotherapeutics. Interested in islets, mentorship, wine, baseball (Mariners), golf, theatre...
New publication @diabetologiajnl.bsky.social led by a fantastic former fellow on our team @hdenroche.bsky.social.
Islet amyloid, long viewed as pathogenic for beta cells, surprisingly disrupts antigen presentation and delays autoimmune diabetes in NOD mice.
Islet amyloid, long viewed as pathogenic for beta cells, surprisingly disrupts antigen presentation and delays autoimmune diabetes in NOD mice.
While islet amyloid harms β cells in T2D, research reveals amyloid protects against β cell autoimmunity and diabetes in NOD mice by disrupting MHCII antigen presentation in islet macrophages link.springer.com/article/10.1... 🔓
Islet amyloid disrupts MHC class II antigen presentation and delays autoimmune diabetes in NOD mice - Diabetologia
Aims/hypothesis Islet amyloid contributes to beta cell failure in type 2 diabetes through several mechanisms, one being the potent induction of local islet inflammation through activating inflammatory...
link.springer.com
January 14, 2026 at 7:14 AM
New publication @diabetologiajnl.bsky.social led by a fantastic former fellow on our team @hdenroche.bsky.social.
Islet amyloid, long viewed as pathogenic for beta cells, surprisingly disrupts antigen presentation and delays autoimmune diabetes in NOD mice.
Islet amyloid, long viewed as pathogenic for beta cells, surprisingly disrupts antigen presentation and delays autoimmune diabetes in NOD mice.
Reposted by Bruce Verchere
CIRTN-R2FIC is currently running in Toronto its 4th Annual Meeting. During this meeting we have launched our mini interview series called "Islets in a Pod" ! Our first interview is with Dr. Patrick MacDonald from the University of Alberta.
youtu.be/UlHn_1Fz3ck?...
youtu.be/UlHn_1Fz3ck?...
#1 Islets in a Pod with Dr. Patrick MacDonald
YouTube video by CIRTN-R2FIC
youtu.be
November 25, 2025 at 4:01 PM
CIRTN-R2FIC is currently running in Toronto its 4th Annual Meeting. During this meeting we have launched our mini interview series called "Islets in a Pod" ! Our first interview is with Dr. Patrick MacDonald from the University of Alberta.
youtu.be/UlHn_1Fz3ck?...
youtu.be/UlHn_1Fz3ck?...
www.canada.ca/en/institute...
An inspired and excellent choice!
Looking forward to great things under Mary's leadership.
An inspired and excellent choice!
Looking forward to great things under Mary's leadership.
Dr. Mary Jung appointed Scientific Director of CIHR Institute of Nutrition, Metabolism and Diabetes - Canada.ca
Dr. Mary Jung appointed Scientific Director of CIHR Institute of Nutrition, Metabolism and Diabetes
www.canada.ca
November 24, 2025 at 7:44 PM
www.canada.ca/en/institute...
An inspired and excellent choice!
Looking forward to great things under Mary's leadership.
An inspired and excellent choice!
Looking forward to great things under Mary's leadership.
Reposted by Bruce Verchere
🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.
November 17, 2025 at 11:26 PM
🧵(1/12) November is Diabetes Awareness Month, and we have many works coming out from the CIRTN labs focusing on islet biology and diabetes. For the beginning of Nov 2025, we have papers from Drs Thompson, Verchere, Chen, Dhanvantari, Hill, Hoesli, Kin, Levings, Lynn, Riddell, Rutter and Wheeler.
Proud to play a small part in this terrific work from @thompsonisletlab.bsky.social
Congrats Camille and Peter on a great paper.
Proinsulin processing and senescence!
@yichunchen.bsky.social @cirtn.bsky.social
Congrats Camille and Peter on a great paper.
Proinsulin processing and senescence!
@yichunchen.bsky.social @cirtn.bsky.social
November 14, 2025 at 7:10 AM
Proud to play a small part in this terrific work from @thompsonisletlab.bsky.social
Congrats Camille and Peter on a great paper.
Proinsulin processing and senescence!
@yichunchen.bsky.social @cirtn.bsky.social
Congrats Camille and Peter on a great paper.
Proinsulin processing and senescence!
@yichunchen.bsky.social @cirtn.bsky.social
Reposted by Bruce Verchere
The interaction of GLP-1 medicines with the immune system is complex, enabled by direct and indirect actions, including neural inter organ communication. These studies have been led @SinaiHealth by CK Wong. His latest perspective here in the JCI www.jci.org/articles/vie...
November 4, 2025 at 11:56 AM
The interaction of GLP-1 medicines with the immune system is complex, enabled by direct and indirect actions, including neural inter organ communication. These studies have been led @SinaiHealth by CK Wong. His latest perspective here in the JCI www.jci.org/articles/vie...
Reposted by Bruce Verchere
A new study from Duke, led by Jonathan Campbell, PhD, reveals that pancreatic alpha cells do more than produce glucagon — they also generate GLP-1, a hormone that boosts insulin and regulates blood sugar.
🔗 Read more: https://medschool.duke.edu/news/alpha-cells-moonlight-secret-glp-1-factories
🔗 Read more: https://medschool.duke.edu/news/alpha-cells-moonlight-secret-glp-1-factories
September 26, 2025 at 4:14 PM
A new study from Duke, led by Jonathan Campbell, PhD, reveals that pancreatic alpha cells do more than produce glucagon — they also generate GLP-1, a hormone that boosts insulin and regulates blood sugar.
🔗 Read more: https://medschool.duke.edu/news/alpha-cells-moonlight-secret-glp-1-factories
🔗 Read more: https://medschool.duke.edu/news/alpha-cells-moonlight-secret-glp-1-factories
Reposted by Bruce Verchere
I recently had the opportunity to chat with Dr. Shazhan Amed about how she is using data in innovative ways to improve outcomes for children and youth living with type 1 diabetes. Thanks to the T2D Network (part of IHSTS) for hosting this conversation. www.youtube.com/watch?v=Eazx...
Empowering Diabetes Care Integrating Health Information
YouTube video by T2D Network
www.youtube.com
October 20, 2025 at 9:47 PM
I recently had the opportunity to chat with Dr. Shazhan Amed about how she is using data in innovative ways to improve outcomes for children and youth living with type 1 diabetes. Thanks to the T2D Network (part of IHSTS) for hosting this conversation. www.youtube.com/watch?v=Eazx...
Reposted by Bruce Verchere
Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...
September 30, 2025 at 4:45 PM
Novel insights into the molecular underpinnings of islet cell dysfunction in #T1D highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity @bcellorg.bsky.social www.jci.org/articles/vie...
Reposted by Bruce Verchere
The first GLP-1 medicine, twice daily exenatide was approved April 28 2005. Several decades later, the pace of innovation is expanding rapidly, encompassing new medicines and receptors, unique delivery options, and expanding therapeutic indications jamanetwork.com/journals/jam...
New Molecules and Indications for GLP-1 Medicines
This Perspective explores recent progress and future directions in glucagon-like peptide-1 medicines.
jamanetwork.com
September 20, 2025 at 6:33 PM
The first GLP-1 medicine, twice daily exenatide was approved April 28 2005. Several decades later, the pace of innovation is expanding rapidly, encompassing new medicines and receptors, unique delivery options, and expanding therapeutic indications jamanetwork.com/journals/jam...
Congratulations and thanks to both Sarah Cs @sarahcrome.bsky.social @sarahcolpitts.bsky.social for including us as part of this lovely study, showing a role or ILC2s in islet graft survival.
🧬 Excited to share our latest study now In Press: In this study led by rising star @sarahcolpitts.bsky.social, we show that IL-10⁺ #ILC2s prevent rejection and improve islet graft survival and function in humanized mouse models. Read more: doi.org/10.1016/j.aj... #Immunology #ImmunoSky #CellTherapy
Redirecting
doi.org
May 26, 2025 at 7:32 PM
Congratulations and thanks to both Sarah Cs @sarahcrome.bsky.social @sarahcolpitts.bsky.social for including us as part of this lovely study, showing a role or ILC2s in islet graft survival.
How nice! Proud to be part of that group of colleagues and child health researchers. What a lovely recognition of recipients and reminder of Dr Hammond's leadership at @bcchresearch.bsky.social.
Fabulous new wall art @bcchresearch.bsky.social celebrating winners of GL Hammond Lectureship over past decade (1/y).
🎉🎉Congrats to all including @mklevings.bsky.social
@wprobins.bsky.social @bruceverchere.bsky.social
& others not on BSky.
🎉🎉Congrats to all including @mklevings.bsky.social
@wprobins.bsky.social @bruceverchere.bsky.social
& others not on BSky.
May 14, 2025 at 1:46 AM
How nice! Proud to be part of that group of colleagues and child health researchers. What a lovely recognition of recipients and reminder of Dr Hammond's leadership at @bcchresearch.bsky.social.
Reposted by Bruce Verchere
New study on novel translation factor EIF2A led by Panzhinskiy as a collaboration between @jimjohnsonsci.bsky.social lab, Jan lab & @bruceverchere.bsky.social lab UBC Life Sciences Institute. Thanks Breakthrough T1D Canada for funding this project #DiabetesResearch link.springer.com/article/10.1...
Eukaryotic translation initiation factor 2A protects pancreatic beta cells during endoplasmic reticulum stress while rescuing global translation inhibition - Diabetologia
Aims/hypothesis The endoplasmic reticulum (ER) stress-induced unfolded protein response helps determine beta cell survival rate in diabetes. The alternative eukaryotic translation initiation factor 2A...
link.springer.com
May 8, 2025 at 6:26 PM
New study on novel translation factor EIF2A led by Panzhinskiy as a collaboration between @jimjohnsonsci.bsky.social lab, Jan lab & @bruceverchere.bsky.social lab UBC Life Sciences Institute. Thanks Breakthrough T1D Canada for funding this project #DiabetesResearch link.springer.com/article/10.1...
Reposted by Bruce Verchere
Come join us at beautiful UBC! The King Lab is recruiting a Post-doc Fellow to develop mathematical theory on infectious disease evolution and emergence, together with Ben Ashby (SFU) #zoonoses #biodiversity www.zoology.ubc.ca/kinglab/join...
Join Us! | King Lab
Are you interested in joining the King Lab? More information here!
www.zoology.ubc.ca
March 31, 2025 at 1:22 AM
Come join us at beautiful UBC! The King Lab is recruiting a Post-doc Fellow to develop mathematical theory on infectious disease evolution and emergence, together with Ben Ashby (SFU) #zoonoses #biodiversity www.zoology.ubc.ca/kinglab/join...
Reposted by Bruce Verchere
We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...
Postdoctoral Research Fellow - Vancouver, British Columbia (CA) job with University of British Columbia Department of Surgery | 12837375
The successful candidate will work on a project developing cell-based therapies for those living with type 1 diabetes (T1D).
www.nature.com
March 10, 2025 at 11:48 PM
We're looking for postdoctoral scholars to join our team in Vancouver 🇨🇦. We work on cell-based approaches aimed at curing type 1 diabetes. Bring your own ideas for projects or work on one that's already funded! More details here: www.nature.com/naturecareer...
Kicking off the ~15th annual A-BC Islet Workshop at beautiful Silver Star resort in BC. Great islet talks from trainees and keynotes @linnemannlab.bsky.social and @soleimanpourlab.bsky.social
@ubcdiabetes.bsky.social
@ubcdiabetes.bsky.social
February 12, 2025 at 5:31 PM
Kicking off the ~15th annual A-BC Islet Workshop at beautiful Silver Star resort in BC. Great islet talks from trainees and keynotes @linnemannlab.bsky.social and @soleimanpourlab.bsky.social
@ubcdiabetes.bsky.social
@ubcdiabetes.bsky.social
Fantastic opportunity for fellowship in an excellent T1D research training environment working in regenerative medicine and stem cells in the Breakthrough T1D Centre of Excellence at UBC. If you missed the NOI deadline, no worries, you can still apply! Reach out if you have any questions.
Are you applying for the J. Andrew McKee Fellowship in Type 1 Diabetes?
Supported by SCN and Breakthrough T1D (formerly JDRF), this is your chance to join UBC’s Breakthrough T1D Centre of Excellence.
Submit your application by February 27, 2025. ➡️ stemcellnetwork.ca/training/exc...
Supported by SCN and Breakthrough T1D (formerly JDRF), this is your chance to join UBC’s Breakthrough T1D Centre of Excellence.
Submit your application by February 27, 2025. ➡️ stemcellnetwork.ca/training/exc...
February 10, 2025 at 8:55 PM
Fantastic opportunity for fellowship in an excellent T1D research training environment working in regenerative medicine and stem cells in the Breakthrough T1D Centre of Excellence at UBC. If you missed the NOI deadline, no worries, you can still apply! Reach out if you have any questions.
Reposted by Bruce Verchere
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
How a Canadian scientist and a venomous lizard helped pave the way for Ozempic - National | Globalnews.ca
In 1984, Dr. Daniel Drucker, an endocrinologist from the University of Toronto, discovered a hormone that helped pave the way for popular diabetes drugs such as Ozempic.
globalnews.ca
February 9, 2025 at 9:58 PM
This is the most relevant article to NIH and research cuts I’ve seen.
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !”
globalnews.ca/news/9793403...
Reposted by Bruce Verchere
We have room and $ for postdoctoral fellows to join our team in beautiful Vancouver 🇨🇦. Get in touch if interested.
January 22, 2025 at 10:53 PM
We have room and $ for postdoctoral fellows to join our team in beautiful Vancouver 🇨🇦. Get in touch if interested.
Reposted by Bruce Verchere
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
We are looking for an imaging master to run a very cool shared microscope - Raman label-free, 2-photon, FLIM, high-res, fast capture, thick live tissue, organoids, high-content screening. We are a dynamic and supportive and fun environment.
We are looking for an imaging master to run a very cool shared microscope - Raman label-free, 2-photon, FLIM, high-res, fast capture, thick live tissue, organoids, high-content screening. We are a dynamic and supportive and fun environment.
Research Associate
Academic Job Category Faculty Non Bargaining Job Title Research Associate Department Johnson Laboratory | Department of Cellular and Physiological Sciences | Faculty of Medicine (James Johnson) Postin...
ubc.wd10.myworkdayjobs.com
December 4, 2024 at 8:05 PM
ubc.wd10.myworkdayjobs.com/en-US/ubcfac...
We are looking for an imaging master to run a very cool shared microscope - Raman label-free, 2-photon, FLIM, high-res, fast capture, thick live tissue, organoids, high-content screening. We are a dynamic and supportive and fun environment.
We are looking for an imaging master to run a very cool shared microscope - Raman label-free, 2-photon, FLIM, high-res, fast capture, thick live tissue, organoids, high-content screening. We are a dynamic and supportive and fun environment.
Reposted by Bruce Verchere
🚀 Excited to announce that our Lab @UBC is recruiting!
🌟 We're looking for passionate intern, graduate, and postdoc with strong coding/ML backgrounds to join us in advancing AI for single-cell biology & brain-computer interfaces.
🏔️ Vancouver awaits!
👉 tanglab.msl.ubc.ca
📧 [email protected]
🌟 We're looking for passionate intern, graduate, and postdoc with strong coding/ML backgrounds to join us in advancing AI for single-cell biology & brain-computer interfaces.
🏔️ Vancouver awaits!
👉 tanglab.msl.ubc.ca
📧 [email protected]
November 28, 2024 at 7:49 PM
🚀 Excited to announce that our Lab @UBC is recruiting!
🌟 We're looking for passionate intern, graduate, and postdoc with strong coding/ML backgrounds to join us in advancing AI for single-cell biology & brain-computer interfaces.
🏔️ Vancouver awaits!
👉 tanglab.msl.ubc.ca
📧 [email protected]
🌟 We're looking for passionate intern, graduate, and postdoc with strong coding/ML backgrounds to join us in advancing AI for single-cell biology & brain-computer interfaces.
🏔️ Vancouver awaits!
👉 tanglab.msl.ubc.ca
📧 [email protected]
Reposted by Bruce Verchere
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Inceptor binds to and directs insulin towards lysosomal degradation in β cells - Nature Metabolism
The insulin inhibitory receptor (inceptor) is found to bind to insulin and to regulate insulin stores by directing proinsulin and insulin towards lysosomal degradation.
doi.org
November 25, 2024 at 11:16 AM
Thrilled to share one of our biggest discoveries: “Inceptor binds to and directs insulin towards lysosomal degradation in beta cells”.
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
doi.org/10.1038/s422...
A tremendous collaborative effort led by JohannaSiehler, Sara Bilekova and other members of the Lickert lab @heikolickert.bsky.social
Reposted by Bruce Verchere
Great to have this paper out in diabetesjournals.org/diabetes! Appreciate the feedback from reviewers and funding from BreakthroughT1D that made this work possible. pubmed.ncbi.nlm.nih.gov/39561351/
November 20, 2024 at 2:45 PM
Great to have this paper out in diabetesjournals.org/diabetes! Appreciate the feedback from reviewers and funding from BreakthroughT1D that made this work possible. pubmed.ncbi.nlm.nih.gov/39561351/
Reposted by Bruce Verchere
And in an effort to build community (after I saw the Swiss starter pack! ) - here's one for scientists in Canada! Let me know who I missed.
go.bsky.app/4owyF32
go.bsky.app/4owyF32
November 22, 2024 at 5:29 PM
And in an effort to build community (after I saw the Swiss starter pack! ) - here's one for scientists in Canada! Let me know who I missed.
go.bsky.app/4owyF32
go.bsky.app/4owyF32
@nictitate.bsky.social deservedly recognized for his outstanding mentorship at the 3rd Canadian Islet Research Training Network meeting in Halifax
November 19, 2024 at 8:39 PM
@nictitate.bsky.social deservedly recognized for his outstanding mentorship at the 3rd Canadian Islet Research Training Network meeting in Halifax