Protein AMPylation is a post-translational modification in which adenosine monophosphate (AMP) from ATP is covalently attached to a target protein via a phosphodiester bond. This reaction is catalyzed...

In this issue of Molecular Cell, Ham et al.1 demonstrate that the metabolite fumarate, when accumulated in cells, can influence mitochondrial quality …

The Morgridge Institute for Research, in partnership with the Department of Biomolecular Chemistry at the University of Wisconsin-Madison, seeks a joint tenure track assistant professor to lead a vibr...

Background: Osteosarcoma (OS) is a primary malignant bone tumor predominantly affecting adolescents. Chemotherapeutic agents, such as cisplatin, are commonly used in OS treatment; however, drug resist...

The immune checkpoint B7-H4 is regulated through post-translational modifications. Here, the authors identify that in breast cancer cells ZDHHC3-catalyzed B7-H4 palmitoylation prevents its lysosomal d...

Protein lipidation is a pivotal post-translational modification that increases protein hydrophobicity and influences their function, localization, and interaction network. Emerging evidence has shown ...

Dynamic palmitoylation modulates protein localization and function. Here, Jayaraman et al develop a toolkit of engineered depalmitoylases to manipulate protein function with spatial, temporal, and sub...

The authors recommend actions that can be taken by individuals, institutions and policymakers to promote gender equity.

Leaving a high-flying job in consulting, Angela Lee Duckworth took a job teaching math to seventh graders in a New York public school. She quickly realized that IQ wasn't the only thing separating the...

The overall impact of arginine metabolism in tumor progression remains unclear. Using clinical analysis, scRNA-seq, and animal models, Zhu et al. identify cancer cell-macrophage metabolic interplay as the key driver of arginine’s impact in breast cancer. This study provides mechanistic insights into leveraging arginine metabolism to enhance antitumor immunity.

Nature Reviews Cancer, Published online: 04 April 2025; doi:10.1038/s41568-025-00816-9The mechanisms of how pH-dependent cell death, alkaliptosis, is regulated are incompletely understood. Chen et al. now demonstrate that the cholesterol biosynthesis protein CYP51A1 suppresses alkaliptosis induced by the opioid analgesic JTC801.

imageimageATG2 is essential for autophagosome biogenesis as it transfers membrane material from the endoplasmic reticulum to growing phagophores. This study reveals that S-palmitoylation dynamically r...