Lightnews — Scholar-powered news

Reposted by Callum P Mutch

paul evan bunce, md @paulbuncemd.bsky.social · Jul 25

call it PCP - you might come across as a relic

call it PJP - you may seem cleverish

either way, don't call it PCP-pneumonia or PJP-pneumonia - you will come across as redundant redundant

this @idiots-pod.bsky.social is a great review of the clinical aspects of pneumocystis infections.

#idsky

115. The Yeasts: PCP/Pneumocytis jirovecii - ID:IOTS - Infectious Disease Insight Of Two Specialists

Listen to this Pretty Comprehensive Pod on PCP. Alyssa and Callum cover:EpidemiologyTaxonomy (PCP vs PJP?)Diagnosis TreatmentNote this pod episode also includes some Positively Jolly Puns on...

idiotspodcasting.buzzsprout.com

3 4 18

Callum P Mutch @callumpmutch.bsky.social · May 15

Edinburgh is such a great place to live and work. Particularly in this sunny may.

Want to work here too (as a med micro +/- ID consultant)?

Well, check out this job advert: apply.jobs.scot.nhs.uk/Job/JobDetai...

Consultant in Medical Microbiology :Various sites

apply.jobs.scot.nhs.uk

Reposted by Callum P Mutch

Jake Scott, MD @jakescottmd.bsky.social · Apr 25

< 72 h from launch → 48 placebo / active-controlled vaccine RCTs logged - now including all 5 COVID trials

1.43 M participants

Crowd-powered, freely accessible evidence that buries the “never placebo-tested” myth.

Browse or drop a PMID 👇
bit.ly/3EuYzqI

cc @bradspellberg.bsky.social

4 17 33

Reposted by Callum P Mutch

Joseph Marcus @josephmarcusid.medsky.social · Apr 20

Two hospital 🇰🇷 retrospective cohort study of ID consult and CLABSIs in the ICU

ID consults associated with:
-faster catheter removal
-more targeted antimicrobials

bmcinfectdis.biomedcentral.com/articles/10....

#IDSky

Impact of early infectious diseases consultation on the management of central line-associated bloodstream infection: a propensity score weighting retrospective cohort study - BMC Infectious Diseases

Background Central line-associated bloodstream infection (CLABSI) is an important healthcare-associated infection, particularly in the intensive care unit (ICU). This study aimed to investigate the im...

bmcinfectdis.biomedcentral.com

1 2 19

Callum P Mutch @callumpmutch.bsky.social · Apr 18

Penicillin Susceptible Staphylococcus aureus IS REAL!

1 4

Callum P Mutch @callumpmutch.bsky.social · Apr 15

"this is all just part of my CPD record"

Seems like a good catchphrase

1 3

Reposted by Callum P Mutch

Angela Huttner @angelahuttner.bsky.social · Apr 15

Now it’s @drneilstone.bsky.social talking about social media and medicine. “Bluesky is the dominant platform now.”
He said it. We will get him over to Bluesky for good! 💪🏼😉😁
#ESCMIDGlobal
#IDSky #MedSky

Dr Neil Stone talking about social media & medicine in Vienna at ESCMID Global.

4 18 61

Reposted by Callum P Mutch

Abid Hussain @amh10.bsky.social · Apr 15

Why is this not happening #ESCMID2025

1 1 2

Callum P Mutch @callumpmutch.bsky.social · Apr 14

Was looking for this content and couldn't find it. I'm newly covering maxfax and ENT areas - couldn't see that much content. Any recommendations on conferences for these?

1

Callum P Mutch @callumpmutch.bsky.social · Apr 14

An example of a commercially available system below.

Strikes me that locally we have all this data but due to different systems there is no way to view as overview and so need to spend time creating summaries.

Consequence of digitised systems rather than digital transformation of care?

Callum P Mutch @callumpmutch.bsky.social · Apr 14

Challenge of clinical decision support systems is the lag of legislation from technological change. Overarching challenge in many areas #escmidglobal

1 2

Callum P Mutch @callumpmutch.bsky.social · Apr 14

There was more covered. Great session!

1

Callum P Mutch @callumpmutch.bsky.social · Apr 14

5. Update on enterococcal breakpoints. Including other species

Remember intrinsic vanc resistance ones! Cassesiflavus and gallinarum

1

Callum P Mutch @callumpmutch.bsky.social · Apr 14

Update on upcoming new anaerobic breakpoints - exciting but methodology difficult and so likely ref lab still

1

Callum P Mutch @callumpmutch.bsky.social · Apr 14

4. Answers to questions about dosing: Generally to use breakpoints table. But in IE breakpoints refer to ESC guidelines. Also rationale for no I category and assumption that highest dose always used

This seems less useful (to me) given issues in ESC dosing tables and clinical data on oral switch.

1

Callum P Mutch @callumpmutch.bsky.social · Apr 14

3. Breakpoints for cefepime-enmetazobactam (always a pleasure to try to spell) and aztreonam-avibactam

1

Callum P Mutch @callumpmutch.bsky.social · Apr 14

2. Stenotrophomonas updated breakpoints:
Updates CoT R breakpoint. ECOFFS for other agents. And a nice bonus on mechanisms of beta lactams resistance

1

Callum P Mutch @callumpmutch.bsky.social · Apr 14

EUCAST updates #ESCMIDglobal

1. Strep pneumonia updated algorithm:

Use oxacillin disk, if >20mm then report A to all beta lactams. If <20mm read benpen 1 unit disk. Great presentation showing data behind and how well differentiates S/I/R

1 1 3

Callum P Mutch @callumpmutch.bsky.social · Apr 14

I'm now not so sure about HECK Yes. Patrick Harris was suggesting we should be more reluctant to switch from piptaz etc to mero based on risk of ampC unless Enterobacter.

Will be interesting to see next ESCMID DTR GN guidelines and IDSA 2025 on AmpC.

But for purposes of teaching, yes - HECK yes!

1

Callum P Mutch @callumpmutch.bsky.social · Apr 14

Interesting chart. Some doubt about oral beta lactams for bacteraemia oral switch given time/MIC concerns and not meeting PD target in Enterobacterales with higher MICs. Was this addressed at all? Perhaps need an organism/MIC specific approach?

2 2

Reposted by Callum P Mutch

Abid Hussain @amh10.bsky.social · Apr 14

This is a sensible bar for IVOS #ESCMID2025

4 2

Callum P Mutch @callumpmutch.bsky.social · Apr 14

It is so complex but Patrick Harris's talk key - clinical data (so far) shows mostly need to worry about Enterobacter CC. So I will watch with interest but likely not teach on till we have more clinical!

1 1

Callum P Mutch @callumpmutch.bsky.social · Apr 14

We talk about inducible AmpC and derepression of AmpC inducible, but what are the mechanisms?

Well, it's complex, but depends on the species. AmpR and PBP4 key players. I might need to watch this talk again.... (and easily can because the conference platform is excellent)! #escmidglobal

2 4

Callum P Mutch @callumpmutch.bsky.social · Apr 14

Useful summary of inducible AmpC - strength of inducement and susceptibility to hydrolysis #escmidglobal

2 6

Callum P Mutch @callumpmutch.bsky.social · Apr 14

Just gotten my head round the public transport and #escmidglobal is almost done! Having pre-paid travel has made it very easy!

2