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Reposted by Camille Berthelot

Institut Pasteur | 130 years of biomedical research @pasteur.fr · 8h

Pour chaque vie, la science agit.
Le Pasteurdon, c’est maintenant !
Soutenez la recherche et celles et ceux qui la font avancer ↘️ pasteurdon.fr
#Pasteurdon

Pour chaque vie, la science agit. Le Pasteurdon, c’est maintenant ! Soutenez la recherche et celles et ceux qui la font avancer. Faites un don sur pasteurdon.fr

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Camille Berthelot @camilleberthelot.bsky.social · 1d

Incredibly proud of @eulalieliorzou.bsky.social who is receiving the L'Oreal-Unesco Prize for Women in Science for her trailblazing PhD work on menstruation and its associated diseases!

www.pasteur.fr/fr/espace-pr...

Six chercheuses pasteuriennes reçoivent le Prix Jeunes Talents France 2025 L’Oréal-UNESCO Pour les Femmes et la Science

Six chercheuses de l’Institut Pasteur viennent de recevoir, le 8 octobre 2025, le Prix Jeunes Talents France 2025 L’Oréal-UNESCO Pour les Femmes et la Science.

www.pasteur.fr

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Reposted by Camille Berthelot

Wolfgang Huber @wkhuber.bsky.social · 22d

Science: only when you write up the manuscript, you realize what you should have done.

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Camille Berthelot @camilleberthelot.bsky.social · Aug 4

Dear Sutanu, thank you for your interest in the lab, unfortunately we are not hiring at the moment.

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Reposted by Camille Berthelot

Arnau Sebé-Pedrós @arnausebe.bsky.social · Jul 15

We are looking for a student to continue our work on chromatin evolution:
www.nature.com/articles/s41...
www.biorxiv.org/content/10.1...

The project with @seanamontgomery.bsky.social will focus on chromatin state readers across eukaryotes.

More info: recruitment.crg.eu/content/jobs...

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Camille Berthelot @camilleberthelot.bsky.social · Jul 15

Coming back to the lab after receiving some good news, and my lab is filled with the sweetest scientists ever!

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Reposted by Camille Berthelot

EvoMG Program @evomg-bcn.bsky.social · May 23

🚨With some delay, we're excited to announce that our proposal for a MSCA Doctoral Network on Evolutionary Medical Genomics (EvoMG-DN) got funded! 🎉

🧬 14 labs and 2 companies across 7 European countries will be coordinated by the EvoMG Joint Program at @crg.eu & @upf.edu.

europa.eu/!NNq63m

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Reposted by Camille Berthelot

Michael Baym @baym.lol · May 13

Yesterday, the NIH R35 “Outstanding Investigator” grant to fund scientists in my lab studying antibiotic resistance was terminated for reasons not related to the content of the science, or any actions taken by me or members of my lab

A screenshot of the termination notice showing "Outstanding Investigator Grants"

A screenshot of the termination notice with "This award is terminated effective the date of this award, due to unsafe antisemitic actions that suggest the institution lacks concern for the safety and wellbeing of Jewish students." highlighted

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Camille Berthelot @camilleberthelot.bsky.social · Mar 24

THANK YOU. I was unreasonably upset that it wasn't in the word list 😂

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Reposted by Camille Berthelot

Institut Pasteur | 130 years of biomedical research @pasteur.fr · Mar 6

Science, research & public health face unprecedented attacks in the U.S.

We stand with our American colleagues & support the Stand Up for Science call.

Join the global march tomorrow, incl. in Paris! 🧪✊

📍 March 7, 13:30 – Place Jussieu
🔗 More info: standupforscience.fr

#StandUpForScience

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Reposted by Camille Berthelot

Inserm @inserm.fr · Mar 6

L’Inserm est solidaire du mouvement Stand Up For Science

presse.inserm.fr/cest-dans-la...

#StandUpForScience2025

L’Inserm est très concerné par le sort de la science et des scientifiques aux Etats-Unis, ayant des relations étroites historiques avec de nombreuses institutions scientifiques américaines et en particulier le NIH et des programmes scientifiques communs.

Plus largement l’Inserm est solidaire du mouvement Stand Up For Science et est solidaire de tous les scientifiques exerçant aux États-Unis, où la liberté académique est aujourd’hui mise à l’épreuve.

L’Institut souhaite rappeler l’importance de la science et du progrès dans le monde actuel, où nous sommes confrontés à de nombreux enjeux de société et de nombreuses crises.

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Camille Berthelot @camilleberthelot.bsky.social · Feb 26

What's a house?

*cries in Parisian*

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Camille Berthelot @camilleberthelot.bsky.social · Feb 4

@clavergne-anth.bsky.social presented their work at ALPHY-AIEM, asking the hard questions: did the evolution of mensuration associate with diversifications in immune genes, to fulfill their new functions in the uterine cycle?

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Camille Berthelot @camilleberthelot.bsky.social · Jan 30

Yes, the irony was not lost on me! I also presented this at conferences a couple of times while very visibly pregnant, so many joke opportunities 😂

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Reposted by Camille Berthelot

Kara McKinley @karalmckinley.bsky.social · Jan 29

I have a wonderful scientist in my lab who is looking to move to Europe. Is anyone looking for a staff scientist? She has a PhD. She is particularly in her element doing field work. Great skills with rodents and very open to non-rodent positions as well.

Please send leads, please amplify!

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Camille Berthelot @camilleberthelot.bsky.social · Jan 29

Thank you!! :D

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Camille Berthelot @camilleberthelot.bsky.social · Jan 29

Thanks to everyone who went above and beyond to make this study happen!

Camille Berthelot @camilleberthelot.bsky.social · Jan 29

Interestingly, one of these genes is LIF, a key biomarker of the implantation window in humans...!

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Camille Berthelot @camilleberthelot.bsky.social · Jan 29

Long story short - we used single-cell transcriptome sequencing in uteri from macaque, marmoset and mouse, and confirmed that a set of key genes for implantation have evolved different convergent patterns in humans and mice, which are shared with (at least these) non-human primates.

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Camille Berthelot @camilleberthelot.bsky.social · Jan 29

Which was unexpected, but could makes sense, as embryo implantation has evolved during primate evolution: it's interstitial in humans, but superficial in macaques.

And in mouse? Different again, but somewhat closer to human - an exemple of convergent evolution.

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Camille Berthelot @camilleberthelot.bsky.social · Jan 29

Surprisingly, we found that genes related by uterine receptivity - how the uterus prepares for embryo implantation - had more similar gene expression patterns in human and mouse, compared to macaques.

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Camille Berthelot @camilleberthelot.bsky.social · Jan 29

And lo and behold, macaque organoids respond to hormones similarly to humans.

EXCEPT. DO THEY?

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Camille Berthelot @camilleberthelot.bsky.social · Jan 29

We sequenced their transcriptomes at basal state and when stimulated by sex hormones, and compared their response with human and mouse organoids...

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Camille Berthelot @camilleberthelot.bsky.social · Jan 29

So what did we do? We grew macaque endometrial epithelial organoids!

They're pretty! They're round! They cycle in response to hormones!

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Camille Berthelot @camilleberthelot.bsky.social · Jan 29

Endometrial epithelial cells line the lumen and glands of the uterus - they fulfill pivotal roles during the cycle and during embryo implantation.

Their evolution is not well understood, although we suspect they underlie some of the functional differences observed in the uteri of different mammals.

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