Yu M, Lin L, Zhou D, Liu S. Interaction design in mRNA delivery systems. J Control Release. 2025;377:413-426. doi:10.1016/j.jconrel.2024.11.038

This review shows the relevance of designing mRNA-LNPs from a biochemical perspective, considering payload and vehicle physicochemical interactions.

🔵 𝗗𝗼𝗲𝘀 𝘆𝗼𝘂𝗿 𝗟𝗡𝗣 𝘄𝗼𝗿𝗸 𝙞𝙣 𝙫𝙞𝙩𝙧𝙤 𝗯𝘂𝘁 𝗳𝗮𝗶𝗹𝘀 𝙞𝙣 𝙫𝙞𝙫𝙤? 𝗔𝘁 𝗖𝗔𝗧𝗨𝗚 𝘆𝗼𝘂 𝗰𝗮𝗻 𝗱𝗲𝘀𝗶𝗴𝗻 𝘆𝗼𝘂𝗿 𝗟𝗡𝗣 𝗳𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻 𝘄𝗶𝘁𝗵 𝗮𝗻 𝗲𝘅𝗽𝗲𝗿𝘁.

Image sourced from the article

3️⃣ Cholesterol analogs, PEG-lipids, and helper lipids like DOPE show highly 𝘀𝗽𝗲𝗰𝗶𝗳𝗶𝗰 𝗶𝗻𝘁𝗲𝗿𝗮𝗰𝘁𝗶𝗼𝗻 𝗽𝗿𝗼𝗳𝗶𝗹𝗲𝘀.
4️⃣ Polymers, peptides, and inorganic carriers demand 𝗽𝗿𝗲𝗰𝗶𝘀𝗲 𝗶𝗻𝘁𝗲𝗿𝗮𝗰𝘁𝗶𝗼𝗻 𝘁𝘂𝗻𝗶𝗻𝗴.
5️⃣ 𝗘𝗺𝗲𝗿𝗴𝗶𝗻𝗴 𝘀𝘁𝗿𝗮𝘁𝗲𝗴𝗶𝗲𝘀 are redefining what’s possible.

Key ideas shared in the article:
1️⃣ Delivery efficiency is shaped by 𝗲𝗹𝗲𝗰𝘁𝗿𝗼𝘀𝘁𝗮𝘁𝗶𝗰, 𝗵𝘆𝗱𝗿𝗼𝗽𝗵𝗼𝗯𝗶𝗰, 𝗵𝘆𝗱𝗿𝗼𝗴𝗲𝗻 𝗯𝗼𝗻𝗱𝗶𝗻𝗴, π-π 𝘀𝘁𝗮𝗰𝗸𝗶𝗻𝗴, 𝗮𝗻𝗱 𝗺𝗲𝘁𝗮𝗹 𝗰𝗼𝗼𝗿𝗱𝗶𝗻𝗮𝘁𝗶𝗼𝗻 𝗶𝗻𝘁𝗲𝗿𝗮𝗰𝘁𝗶𝗼𝗻𝘀.
2️⃣ These forces govern 𝗲𝗻𝗰𝗮𝗽𝘀𝘂𝗹𝗮𝘁𝗶𝗼𝗻, 𝘀𝘁𝗮𝗯𝗶𝗹𝗶𝘁𝘆, 𝘁𝗮𝗿𝗴𝗲𝘁𝗶𝗻𝗴, 𝗲𝗻𝗱𝗼𝘀𝗼𝗺𝗮𝗹 𝗲𝘀𝗰𝗮𝗽𝗲, 𝗮𝗻𝗱 𝗿𝗲𝗹𝗲𝗮𝘀𝗲.

🔵 𝗔𝘁 𝗖𝗔𝗧𝗨𝗚, 𝘄𝗲 𝘀𝗽𝗲𝗰𝗶𝗮𝗹𝗶𝘇𝗲 𝗶𝗻 𝗗𝗡𝗔, 𝗥𝗡𝗔, 𝗮𝗻𝗱 𝗟𝗡𝗣 𝘁𝗲𝗰𝗵𝗻𝗼𝗹𝗼𝗴𝗶𝗲𝘀. We support researchers from early discovery and proof-of-concept to clinical trials and commercialization. From sequence optimization to LNP formulation and GMP-grade manufacturing.

As a proud 𝗘𝗧𝗣𝗡 𝗣𝗹𝗮𝘁𝗶𝗻𝘂𝗺 𝗺𝗲𝗺𝗯𝗲𝗿, we were honored to sponsor this wonderful event.

ETPN Associacion, NANOMED Spain, and Alexandre Ceccaldi for this thoughtful and well-curated conference.

Thank you team, Cesare Di Nitto, Cristina Kim Xuan Nguyen and Alejandra Carreira.

- 𝗢𝗿𝗴𝗮𝗻-𝗼𝗻-𝗮-𝗰𝗵𝗶𝗽 𝘀𝘆𝘀𝘁𝗲𝗺𝘀 are emerging as essential tools for early-stage validation, offering a potential alternative to animal testing. Many research groups have already integrated them into their pipelines, with others planning to follow.

- 𝗥𝗡𝗔-𝗯𝗮𝘀𝗲𝗱 𝘁𝗵𝗲𝗿𝗮𝗽𝗶𝗲𝘀 continue to attract growing interest thanks to their versatility in vaccines, gene editing, and protein replacement strategies.

- 𝗖𝗔𝗥-𝗧 𝗮𝗻𝗱 𝗰𝗲𝗹𝗹 𝘁𝗵𝗲𝗿𝗮𝗽𝗶𝗲𝘀 are gaining ground as promising approaches for cancer treatment and beyond.

- 𝗢𝗿𝗴𝗮𝗻-𝗼𝗻-𝗮-𝗰𝗵𝗶𝗽 𝘀𝘆𝘀𝘁𝗲𝗺𝘀 are emerging as essential tools for early-stage validation, offering a potential alternative to animal testing. Many research groups have already integrated them into their pipelines, with others planning to follow.

We are excited about the opportunities ahead and look forward to advancing hashtag#RNAtherapeutics through meaningful global partnerships.

Thank you Mohamed ElSayed, Ph.D. Sissi (Xi) Lin and Tommy D. for the visit, were very happy to have you.

Lin Jin, Mengfei Sun, 冯璐雯, Weicheng (Michael) Zhang

NATi is a national initiative driving the growth of nucleic acid therapeutics in Singapore and internationally. Both parties had very insightful discussions focused on exploring potential collaboration for early stage discovery projects, followed by CATUG lab tour.

This work demonstrates how targeted LNPs are effective and selective vehicles for gene therapeutics in cancer treatment.

🔵 𝗔𝘁 𝗖𝗔𝗧𝗨𝗚, 𝘄𝗲 𝗰𝗮𝗻 𝘀𝘆𝗻𝘁𝗵𝗲𝘀𝗶𝘇𝗲, 𝗼𝗽𝘁𝗶𝗺𝗶𝘇𝗲 & 𝗲𝗻𝗰𝗮𝗽𝘀𝘂𝗹𝗮𝘁𝗲 𝗰𝘂𝘀𝘁𝗼𝗺 𝗗𝗡𝗔 𝗮𝗻𝗱 𝗥𝗡𝗔 𝗶𝗻𝘁𝗼 𝗟𝗡𝗣𝘀.

👉🏻 catug.bio/contractrese...

Findings:
✔️ Dual-targeted LNPs 𝗶𝗺𝗽𝗿𝗼𝘃𝗲𝗱 𝘂𝗽𝘁𝗮𝗸𝗲 across HER2-low, medium, and high cell lines
✔️ 𝗧𝗿𝗮𝗻𝘀𝗴𝗲𝗻𝗲 𝗲𝘅𝗽𝗿𝗲𝘀𝘀𝗶𝗼𝗻 𝘄𝗮𝘀 𝗵𝗶𝗴𝗵𝗲𝗿 than with standard LNPs.
✔️ In vivo validation confirmed 𝘀𝘂𝗽𝗲𝗿𝗶𝗼𝗿 𝘁𝗮𝗿𝗴𝗲𝘁𝗶𝗻𝗴 𝗮𝗻𝗱 𝘁𝗿𝗮𝗻𝘀𝗳𝗲𝗰𝘁𝗶𝗼𝗻 in zebrafish xenografts.

Join us to explore the next generation of #RNA innovation!

Drop us a message here 👉🏻 catug.bio/contact

𝗔𝗿𝗲 𝘆𝗼𝘂 𝘄𝗼𝗿𝗸𝗶𝗻𝗴 𝗼𝗻 𝗥𝗡𝗔 𝘁𝗵𝗲𝗿𝗮𝗽𝗲𝘂𝘁𝗶𝗰𝘀?

Check out our brochure: lnkd.in/dKUK8Gf4

🔵 𝗔𝘁 𝗖𝗔𝗧𝗨𝗚 𝘄𝗲 𝗵𝗲𝗹𝗽 𝘆𝗼𝘂 𝗳𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗲, 𝘁𝗲𝘀𝘁 𝗮𝗻𝗱 𝗺𝗮𝗻𝘂𝗳𝗮𝗰𝘁𝘂𝗿𝗲 𝗰𝘂𝘀𝘁𝗼𝗺 𝗺𝗥𝗡𝗔-𝗟𝗡𝗣.

• We saw several applications of #AI in cell and gene therapy, including its 𝗔𝗜-𝗱𝗿𝗶𝘃𝗲𝗻 𝗱𝗲𝘃𝗲𝗹𝗼𝗽𝗺𝗲𝗻𝘁 𝗼𝗳 𝗥𝗡𝗔 𝗮𝗻𝗱 𝗟𝗡𝗣 𝗳𝗼𝗿𝗺𝘂𝗹𝗮𝘁𝗶𝗼𝗻𝘀.

• Last but not least, we celebrated a major milestone at ASGCT: 𝘁𝗵𝗲 𝗳𝗶𝗿𝘀𝘁 𝗵𝘂𝗺𝗮𝗻 𝘁𝗿𝗲𝗮𝘁𝗲𝗱 𝗳𝗼𝗿 𝗮𝗻 𝗶𝗻𝗰𝘂𝗿𝗮𝗯𝗹𝗲 𝗺𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗱𝗶𝘀𝗲𝗮𝘀𝗲 𝘂𝘀𝗶𝗻𝗴 𝗯𝗮𝘀𝗲 𝗲𝗱𝗶𝘁𝗶𝗻𝗴.