Ben Engel
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cellarchlab.com
Ben Engel
@cellarchlab.com
cellarchlab.com Univ. of Basel Biozentrum🇨🇭. Exploring molecular architecture inside cells with #CryoEM #TeamTomo. Plants and algae in a changing climate. ❄🔬 OF 🌿 4THE 🌍!
Interesting SPFH proteins! And yeah, there are many putative Prohibitins between the inner and outer mito membranes, which @florentwaltz.bsky.social averaged (see the paper). He also tried averaging those lightbulbs but didn't get much — They seem to be heterogeneous. Another #TeamTomo mystery 🕵️🔬⁉️ 🧪
December 28, 2025 at 1:29 PM
That's a beaut! Also connects nicely to three of the primary stains used in your study... nice one! 👩‍🎨👩‍🔬
December 28, 2025 at 5:51 AM
That's a nice mito!! In addition to the crispy ATP synthases and Respirasomes all over the many cristae, I spy one of @florentwaltz.bsky.social's mysterious unidentified "lightbulbs"💡on the outer membrane. #TeamTomo 🧪

For more, see here: www.science.org/doi/10.1126/...
In-cell architecture of the mitochondrial respiratory chain
Mitochondria regenerate adenosine triphosphate (ATP) through oxidative phosphorylation. This process is carried out by five membrane-bound complexes collectively known as the respiratory chain, workin...
www.science.org
December 28, 2025 at 4:31 AM
Of course, silly me, our resource paper is online already
@cp-molcell.bsky.social. The "print" version will be out in a week... #TeamTomo 🧪

www.sciencedirect.com/science/arti...
Toward community-driven visual proteomics with large-scale cryo-electron tomography of Chlamydomonas reinhardtii
In situ cryo-electron tomography (cryo-ET) has emerged as the method of choice to investigate the structures of biomolecules in their native context. …
www.sciencedirect.com
December 28, 2025 at 3:32 AM
Thanks Brett! Hey Charles, please start here and ping @lifeonthewedge.bsky.social and @paloha.bsky.social if you have any questions. FYI, the journal version of our paper will be out in a week 👀

github.com/Chromatin-St...
GitHub - Chromatin-Structure-Rhythms-Lab/ChlamyAnnotations: Particle annotations for the large-scale cryo-ET dataset of Chlamydomonas reinhardtii
Particle annotations for the large-scale cryo-ET dataset of Chlamydomonas reinhardtii - Chromatin-Structure-Rhythms-Lab/ChlamyAnnotations
github.com
December 28, 2025 at 3:26 AM
That squid gets around! I recognize it from the sticker Ariane slapped on my office door 🦑
December 1, 2025 at 11:39 AM