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Chang Liu @chang-c-liu.bsky.social · 25d

I'm very sad to learn of Prof. Andrew D. Hanson's passing. Andrew was a pioneering plant (synthetic) biologist full of insight, clarity of thought, and vision. He was also exceptionally kind and wise. I will cherish our interactions and collaborations. blogs.ifas.ufl.edu/hosdept/2025...

Onwards and Upwards: Remembering Dr. Andrew D. Hanson - Horticultural Sciences Department

Honoring Dr. Andrew D. Hanson, Eminent Scholar and UF Hort Sci Professor, whose visionary research and mentorship shaped plant biology.

blogs.ifas.ufl.edu

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Chang Liu @chang-c-liu.bsky.social · Aug 18

Love it! Congrats Jeff and team!

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Reposted by Chang Liu

Jeff Martell @jeffmartell.bsky.social · Aug 14

Excited to share our new preprint, which was years in the making! chemrxiv.org/engage/chemr...
New reactions are typically developed by trial and error. How can we speed up this process? Read on to learn how we used DNA scaffolding to perform >500,000 parallel reactions on attomole scale.
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DNA-Scaffolded Ultrahigh-Throughput Reaction Screening

Discovering and optimizing reactions is central to synthetic chemistry. However, chemical reactions are traditionally screened using relatively low-throughput methods, prohibiting exploration of diver...

chemrxiv.org

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Reposted by Chang Liu

Nature Chemical Biology @natchembio.nature.com · Aug 1

A new paper from @aliceyting.bsky.social reports on LaccID, an engineered laccase, that enables hydrogen peroxide-free proximity labeling and electron microscopy of cell surfaces

www.nature.com/articles/s41...

Directed evolution of LaccID for cell surface proximity labeling and electron microscopy - Nature Chemical Biology

LaccID, an engineered laccase, enables hydrogen-peroxide-free proximity labeling and electron microscopy (EM) in mammalian cells. Notably, LaccID is selectively active at the cell surface, enabling th...

www.nature.com

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Chang Liu @chang-c-liu.bsky.social · Aug 16

Our new company, K2 Therapeutics, is off to the races to develop new antibody drugs that target multipass membrane proteins. We are hiring so check us out! www.k2-tx.com/home#careers

K2 Therapeutics

www.k2-tx.com

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Chang Liu @chang-c-liu.bsky.social · Aug 8

Happy to see this new T7 replicon based orthogonal replication system in E. coli. Congrats to the Diercks and Schultz lab teams at Scripps Research! www.science.org/doi/10.1126/...

An orthogonal T7 replisome for continuous hypermutation and accelerated evolution in E. coli

Systems that perform continuous hypermutation of designated genes without compromising the integrity of the host genome can substantially accelerate the evolution of new or enhanced protein functions....

www.science.org

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Reposted by Chang Liu

Katherine Xue @ksxue.bsky.social · Jul 17

The Xue lab at UC Irvine is looking for a staff scientist to support our work investigating how microbes interact and evolve in the gut microbiome! Open to a wide range of previous experience levels, see ad for more.
recruit.ap.uci.edu/JPF09601

Junior, Assistant, or Associate Specialist – Xue Lab

University of California, Irvine is hiring. Apply now!

recruit.ap.uci.edu

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Chang Liu @chang-c-liu.bsky.social · Jul 15

Congrats Olek!

Chang Liu @chang-c-liu.bsky.social · Jul 15

We find that low copy number accelerates fixation of beneficial mutants while high copy number lets more deleterious alleles hitchhike in cells with fit alleles. High copy number also promotes a form of functional robustness through maintenance of allelic diversity.

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Chang Liu @chang-c-liu.bsky.social · Jul 15

Happy to share this work, led by Olek Pisera, on dialing in a wide range of copy numbers for the orthogonal plasmid of OrthoRep. We used this ability to study how plasmid copy number influences evolutionary outcomes. www.nature.com/articles/s41...

The role of plasmid copy number and mutation rate in evolutionary outcomes - Nature Ecology & Evolution

In an experimental multicopy plasmid evolution system that allows manipulation of mutation rate and copy number, low copy number promoted enrichment of beneficial alleles whereas high copy number main...

www.nature.com

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Chang Liu @chang-c-liu.bsky.social · May 24

Happy to share the peer-reviewed and updated version of our work on OrthoRep-driven evolution of aaRSs for genetic code expansion with unnatural amino acids. Congrats to Yuichi Furuhata, a true master bioengineer, on leading this excellent work! www.nature.com/articles/s41...

Directed evolution of aminoacyl-tRNA synthetases through in vivo hypermutation - Nature Communications

Genetic code expansion (GCE) enables the incorporation of new amino acids into proteins. Here, authors demonstrate the rapid OrthoRep-driven evolution of aminoacyl-tRNA synthetases for GCE, increasing...

www.nature.com

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