The Cardiac Center at the Children’s Hospital of Philadelphia (CHOP) is leading pioneering research with grants aimed at improving outcomes for children with severe cardiac conditions. These efforts represent a comprehensive approach to advancing cardiac care from prenatal stages through childhood, potentially transforming treatment paradigms.

Kelchtermans et al. analyze interactions between prematurity, PM2.5 exposure and genetic susceptibility on asthma exacerbations in children. They find that combined effects produce outsized increases in exacerbation risk, underscoring the need for targeted interventions.