Patricoski-Chavez et al. use a deep learning-based model with attention mechanisms that integrates clinical, mutation, and mRNA expression data from patients to predict early versus late glioma recurrence. The model outperforms traditional machine learning approaches across two independent datasets.

Bahmani, Cha, Alavi, Dixit et al. evaluate an AI-facilitated precision medicine learning platform they built, Stanford Data Ocean. The platform, which provided 3594 costfree certification accesses across 93 countries, demonstrates positive training outcomes across bioinformatics topics for low and middle income learners.

Alahmari et al. combine orthotopic liver transplantation with haploidentical hematopoietic stem cell transplant in patients with severe SCD and advanced liver disease. They demonstrate the feasibility of this dual approach, with stable engraftment and immune tolerance achieved through a nonmyeloablative conditioning regimen.

Matsuura et al. examine maternal genetic factors impact on cervical length and changes during pregnancy, which may predict spontaneous preterm birth (sPTB). This study of over 5,000 Black/African American women found many genetic loci associated with sPTB act through cervical remodeling, with links to hormone signaling pathways.

With this Collection, a partnership between Nature Communications, Communications Medicine, Communications Biology, and Scientific Reports, we welcome ...

Through this cross-journal Collection, the editors at Communications Medicine, Nature Communications, Nature Microbiology, Nature Health, and Scientific ...

Li, Wu et al. investigate the associations between monthly anomalous temperatures and mortality rates for individuals under five years old in low- and middle-income countries. They find that the effects of anomalous temperature on child mortality vary by temperature zone, reflecting the adaptive capacity of populations to local climates.

Tan et al. apply a metagenomic lens to describe the Plasmodium species and intra-species complexity in asymptomatic carriers in a Northern Sahelian community in Ghana. This deep dive into the complexi...

Sedaghat et al. examine the association between proteomics-based aging clocks (PAC) during midlife and late-life and the risk of dementia in individuals from two large prospective population-based cohort studies. They find that the PACs are associated with lower cognition and a higher risk of dementia in midlife and more prominently in late-life.

Matsuura et al. examine maternal genetic factors impact on cervical length and changes during pregnancy, which may predict spontaneous preterm birth (sPTB). This study of over 5,000 Black/African American women found many genetic loci associated with sPTB act through cervical remodeling, with links to hormone signaling pathways.

Huang et al. investigate serum metabolomic profiles from aging cohorts in Taiwan and Japan to identify biomarkers of physio-cognitive decline syndrome. They report significant alterations in glutathione, tryptophan, and bile acid pathways, with metabolites including creatinine and 3-hydroxykynurenine as potential indicators.

Dubey et al. use a large database representing US hospitalizations to investigate the relationship between mental disorders and obstetric outcomes. The results suggest that different mental disorders are associated with obstetric outcomes differently, indicating the need for screening and management of mental disorders during obstetrical care.

Nyarko and Santa et al. explore AI and digital health utilization for childhood cancer care in Ghana. Collaborative efforts among the government, health institutions, and international organizations are essential to drive investments in digital infrastructure, capacity building, and policy development in Ghana.

Providencia et al. evaluate the diagnostic accuracy of simplified diagnostic algorithms for suspected acute rheumatic fever and assess the impact of different diagnostic criteria on the development of rheumatic heart disease. Simplification may lead to underdiagnosis, and some patients who do not meet criteria for acute rheumatic fever may still develop rheumatic heart disease.

Providencia et al. evaluate the diagnostic accuracy of simplified diagnostic algorithms for suspected acute rheumatic fever and assess the impact of different diagnostic criteria on the development of rheumatic heart disease. Simplification may lead to underdiagnosis, and some patients who do not meet criteria for acute rheumatic fever may still develop rheumatic heart disease.

Meyer-Arndt et al. evaluate fear processing in people with Multiple Sclerosis (MS) and anxiety. People with MS and anxiety overgeneralize fear, with a machine learning model trained to associate behavioral to neural fear responses in healthy persons being able to predict behavior from neural responses in people with MS with and without anxiety.

Uwizeye et al. examine the association between epigenetic age and prenatal exposure to maternal stress related to genocide and genocidal rape. Findings reveal prenatal exposure to this type of maternal stress accelerates epigenetic aging and suggest that third and fourth-generation clocks more accurately capture these relationships.

Meyer-Arndt et al. evaluate fear processing in people with Multiple Sclerosis (MS) and anxiety. People with MS and anxiety overgeneralize fear, with a machine learning model trained to associate behavioral to neural fear responses in healthy persons being able to predict behavior from neural responses in people with MS with and without anxiety.

Ma, Wang, Meng et al. conducted a retrospective study to investigate the impact of using smart watches in intensive care units (ICU) on alarm response and the impact on the work efficiency of nursing staff. Response times shortened leading to fewer high-level and fatal alarms and reduced durations of mechanical ventilation and ICU stays.

Le, Phung, Bui et al. investigate nasal-spraying Bacillus spore probiotics (LiveSpo Navax) as a supportive treatment for Respiratory Syncytial Virus pneumonia with bacterial co-infections in young children. Use of the probiotic reduces symptoms, antibiotic use, viral and bacterial loads, and improves immune and nasal microbiota.

Roebuck et al. analysed 922,149 records to investigate the impact of midwife continuity of carer throughout the perinatal period in England on stillbirth and first newborn feed. They find an increase in first feed of breast milk, reduced stillbirth in Black women, and increased stillbirth in women not receiving any antenatal care by 24 weeks.

Macchia et al. used nationally representative data from 22 countries (N = 202,898) and a random effects meta-analysis to examine 13 childhood predictors of physical pain in adulthood. Findings show that childhood experiences, personal attributes, and familial and social circumstances have meaningful and varied associations with adulthood pain.

Gray et al. examine the weight trends in women using data from the Ghana Demographic and Health Study. Findings reveal that obesity poses a more substantial public health challenge than being underweight and that increases in obesity with age, combined with an aging population, could lead to continued rises in obesity rates.

Okafor et al. analyze survey responses from adults in 22 countries to explore differences by age, gender, education, and other characteristics in their rating of their mental health. Self-rated mental health is generally higher in some African countries and among older adults, men, married individuals, and frequent religious service attendees.

Cheng and Lama et al. developed a synergistic dual-modality AI framework for prediction of MMRd/MSI-High status in colorectal cancer and PD-L1 status in breast cancer. Their model, which analyzes H&E and IHC images, achieves clinical grade performance and identifies patients with improved outcomes on pembrolizumab immunotherapy.