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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 17h

👏 Congratulations to all co-authors

🙏 Many thanks to all participants, SHCS physicians, research personnel, and funders who made this innovation possible!

@snsf.ch @FAG Basel

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 17h

Our mixed-methods study explored the barriers and facilitators of this implementation process.

🧩 Full open-access article @jclinepi.bsky.social : www.sciencedirect.com/science/arti...

Implementing a randomization consent to enable Trials within Cohorts in the Swiss HIV Cohort Study – A mixed-methods study

Trials within Cohorts (TwiCs) is a promising design to make randomized trials more efficient. Cohort participants are asked for consent to be randomiz…

www.sciencedirect.com

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · 17h

Trials within Cohorts (#TwiCs) is an innovative study design that embeds randomized trials directly within ongoing cohort studies.

The Swiss HIV Cohort Study (#SHCS) — a well-established, nationwide cohort — has now implemented the TwiCs design for the first time in Switzerland.

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · Sep 8

Here the full story: jamanetwork.com/journals/jam...

Well presented Johannes👏

Nonregistration, Discontinuation, and Nonpublication of Randomized Trials

This systematic review describes the percentages of randomized clinical trials approved in 2016 that are unregistered, prematurely discontinued, or unpublished.

jamanetwork.com

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Reposted by Clinical Epidemiology Basel

JAMA Network Open @jamanetworkopen.com · Sep 6

Today at #PRC10: Analysis of 347 RCTs in Europe and Canada in 2016

Co-author @schwenkej.bsky.social found industry-sponsored trials were more often completed and available.

🔗 Read the study: ja.ma/41I2etz

@peerreviewcongress.bsky.social

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Reposted by Clinical Epidemiology Basel

Peer Review Congress #PRC10 @peerreviewcongress.bsky.social · Sep 5

Nonregistration, premature discontinuation due to poor recruitment, and nonpublication of #RCT results remain major challenges, especially for nonindustry trials
@schwenkej.bsky.social @clinepi-basel.bsky.social
@unibas.ch @mcmasteruniversity.bsky.social
#OpenScience #MetaResearch #PeerReview

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · Aug 28

📝 New study: Mental health & substance use among adolescents in Lesotho🇱🇸

Older teens (15–17) most affected: girls → more mental health issues, boys → more substance use.
Yet only 17% accessed care.
Urgent need for youth-friendly services.

Read more:
onlinelibrary.wiley.com/doi/10.1111/...

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jul 30

ART works — but strong monitoring & infant care are key to ending vertical HIV transmission.

Full article: onlinelibrary.wiley.com/doi/10.1111/...

onlinelibrary.wiley.com

Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jul 30

The challenge? Only 44% of cases had viral load monitoring in line with guidelines. Infant testing & prevention were also inconsistent.

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jul 30

In a study of 353 pregnancies among people living with HIV, vertical transmission was just 1% — far below the ~33% expected without treatment.

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jul 30

🤰🤱 New data from Lesotho: Antiretroviral therapy during pregnancy & breastfeeding is preventing infants from HIV. But there’s still more to do. 🧵

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jul 28

ComBaCaL also powers Trials within Cohorts, testing community-led interventions to boost treatment & control for NCDs. More here: bmjopen.bmj.com/content/15/7...

Cohort profile: the open, prospective Community-Based chronic Care Lesotho (ComBaCaL) cohort – design, baseline chronic disease risk factors and hypertension and diabetes care cascades

Purpose The open, prospective Community-Based chronic Care Lesotho (ComBaCaL) cohort is the first study to comprehensively investigate socioeconomic indicators, common chronic diseases and their risk ...

bmjopen.bmj.com

Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jul 28

Findings show heavy burdens:

Hypertension: 17%
Diabetes: 4%
HIV: 15%

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jul 28

🚨New publication!

📝 Community-Based chronic Care Lesotho (ComBaCaL) cohort profile

a cohort of 14,700+ people in rural Lesotho, uncovering the intersection of chronic disease, poverty, & care access.

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jul 8

💇🏾‍♀️ New publication from our team: Hair Salons as a promising space to provide HIV & Sexual and SRH services for young women in Lesotho

💭 The team is currently looking for funding to implement a pilot - ideas welcome!

Read more here: bmcpublichealth.biomedcentral.com/articles/10....

Hair salons as a promising space to provide HIV and sexual and reproductive health services for young women in Lesotho: a citizen scientist mixed-methods study - BMC Public Health

Introduction Adolescent girls and young women in southern Africa are disproportionately affected by HIV and sexual and reproductive health (SRH) challenges. There is a need for more accessible and de-...

bmcpublichealth.biomedcentral.com

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jul 3

🥁Now publication on the availability of trial protocols!

🔗Check out the link for the open access paper:
www.sciencedirect.com/science/arti...

@jclinepi.bsky.social @unibas.ch @dkf.unibas.ch @snsf.ch

Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jun 23

Grace Yoon, Natalie Johnson, Moleboheng Mokebe, Palesa Mahlatsi, Malebanye Lerotholi, Niklaus Labhardt, Nadine Tschumi, Alastair van Heerden, Jennifer M. Belus, Irene Falgas-Bague

Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jun 23

www.cambridge.org/core/journal...

Face-to-face, confidential and health worker-led: Understanding the preferences for behavioral health services among people with HIV in Lesotho | Cambridge Prisms: Global Mental Health | Cambridge Cor...

Face-to-face, confidential and health worker-led: Understanding the preferences for behavioral health services among people with HIV in Lesotho - Volume 12

www.cambridge.org

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jun 23

💡 New study on behavioral health for people with HIV in Lesotho 🇱🇸: Phone-based care has pros & cons, but trusted individuals are key for support & accountability. From Butha-Buthe and Mokhotlong. 🧑‍⚕️📞👥
Read more 👉

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jun 20

🌞 ClinEpi Summer Event 2025

We just wrapped up an unforgettable summer event featuring fun quizzes & games and ending off with an exciting cooking challenge 🍴 A huge thank you to everyone who joined, competed and organised this event, we are already looking forward to the next one!

Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jun 6

Grateful to all [email protected] @unibas.ch @dkf.unibas.ch @ox.ac.uk and to all participating journals from the @bmj.com! 🤝

Clinical Epidemiology Basel @clinepi-basel.bsky.social · Jun 6

Our secondary analysis of 533 peer reviewer reports found that reminders about reporting guidelines increased reviewer attention—but the effect diminished due to article rejections and limited implementation by authors.

🔗Full [email protected] : www.sciencedirect.com/science/arti...

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Clinical Epidemiology Basel @clinepi-basel.bsky.social · May 20

New publication from our team: Drivers of chronic depressive and harmful alcohol use symptoms among adults living with HIV in Lesotho: pathways for integrated interventions

🔗: www.sciencedirect.com/science/arti...

Drivers of chronic depressive and harmful alcohol use symptoms among adults living with HIV in Lesotho: pathways for integrated interventions

Mental health problems are prevalent among people with HIV (PWH) in Southern Africa. However, mental health problems are substantially under-diagnosed…

www.sciencedirect.com

Clinical Epidemiology Basel @clinepi-basel.bsky.social · May 19

🚀 Join us for Geneva Digital Health Day 2025! 🌍💻

Felix Gerber will give a short presentation on digital innovation in low- and middle-income countries.

📅 Date: Thursday, 22 May 2025
🕘 Time: 09:00–17:30 CET
📍 Location: Campus Biotech, Geneva, Switzerland
🔗 Register here: gdhub.org/25gdhd/

Clinical Epidemiology Basel @clinepi-basel.bsky.social · May 16

🚀 New study out

Clinical trials often face overoptimistic budgets and funding shortfalls, leading to costly trial discontinuations. We reviewed Swiss budgeting tools and found untested, inconsistent methods without prespecified cost ranges.

Article: trialsjournal.biomedcentral.com/articles/10....

Clinical trial budgeting approaches in Switzerland—a meta-research study - Trials

Background Conducting clinical trials is resource demanding. Mirroring challenges experienced elsewhere, clinical trials conducted in Switzerland often face overoptimistic budget estimations and insuf...

trialsjournal.biomedcentral.com