Cliona O’Farrelly
@clionaofarrelly.bsky.social
770 followers
380 following
76 posts
scientist, human rights activist, reader
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Waggoner Lab
@labwaggoner.bsky.social
· Jul 7
IL-17A-secreting γδ T cells promote resistance to CDK4/CDK6 inhibitors in HR+HER2− breast cancer via CX3CR1+ macrophages - Nature Cancer
Petroni et al. report that the infiltration of IL-17A-secreting γδ T cells in the tumor microenvironment coupled with the accumulation of immunosuppressive macrophages is associated with resistance to...
www.nature.com
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Reposted by Cliona O’Farrelly
Reposted by Cliona O’Farrelly
Reposted by Cliona O’Farrelly
Reposted by Cliona O’Farrelly
γδ T cell Forum
@forum-gd.bsky.social
· Jul 5
T cell receptor γδ is a critical, real-time determinant of unique tissue surveillance mechanisms
γδ T cells are mediators of immunosurveillance used in the clinic. However, their status remains paradoxical. While many display overt traits of adaptive immunity, several major γδ cell subsets includ...
www.researchsquare.com
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Reposted by Cliona O’Farrelly
Reposted by Cliona O’Farrelly
Reposted by Cliona O’Farrelly
Reposted by Cliona O’Farrelly
Waggoner Lab
@labwaggoner.bsky.social
· Jun 11
Interferon-epsilon, an estrogen-induced type I interferon, is uniquely exploited by Neisseria gonorrhoeae via effects on sialic acid metabolism
Kurt-Jones et al. examined IFN-ε, a hormone-responsive type I IFN expressed by genital
epithelial cells, during Neisseria gonorrhoeae (Ng) infection. They demonstrated that
mice lacking IFN-ε exhibit ...
www.cell.com