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Reposted by Living Safely With Covid

Solid Evidence @solidevidence.bsky.social · 5d

I just updated our cryptic lineage dashboard if anyone is interested.

Viewer warning: this site contains a ton of actual data that really long persistent COVID infections are still occurring.

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dholab.github.io/public_viz/0...

SARS-CoV-2 Cryptic Lineage Visualizations

dholab.github.io

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newt @muddynewt.bsky.social · Mar 28

There are actually so many cuties on Refresh Connections and the fact they're all Covid conscious makes it even better 😭💕💕

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The Safer Air Project @saferairproject.bsky.social · 7d

An excellent article by Amanda Kvalsvig and Anna-Maria Arabia, with contribution by Dr Bronwyn King AO, highlighting the reasons that indoor air quality matters more than ever, and how to translate the evidence into meaningful action.

theconversation.com/why-investme...

Why investment in clean indoor air is vital preparation for the pandemics and climate emergencies to come

Unchecked airborne infections cost billions in lost health and productivity each year – likely more than the cost of better ventilation to clean up indoor air.

theconversation.com

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J. Offir, PhD @joffirphd.bsky.social · 8d

Long covid & kids - details below:

🔹️"Children and teenagers are twice as likely to develop long Covid after a second coronavirus infection as after an initial infection, a large new study has found. The research provides evidence that Covid reinfections can...

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www.nytimes.com/2025/09/30/h...

Long Covid Risk for Children Doubles After a Second Infection, Study Finds

www.nytimes.com

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Dr Fabrício Campos @camposvet.bsky.social · 8d

🔬 The compound, based on 6-methoxypyrimidine and with low molecular weight (306 g/mol), selectively inactivates Mpro. After optimization, the candidate PH521 (16f) proved to be 11 times more potent than the initial one, with antiviral activity confirmed in cells. (2/3)

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Dr Fabrício Campos @camposvet.bsky.social · 8d

🚨 New breakthrough against COVID-19

A study led by Prof. Saulo Fernandes (School of Pharmacy/UFRGS), in which I am a co-author, identified a new class of reversible inhibitors of the main protease (Mpro) of SARS-CoV-2 – an essential enzyme for viral replication. (1/3)

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Dr Fabrício Campos @camposvet.bsky.social · 8d

💊 This breakthrough paves the way for the development of new, fast-acting and effective antiviral therapies against coronavirus.

📄 Read the full preprint: dx.doi.org/10.2139/ssrn...

#COVID19 #Antivirals #ScientificDiscovery #DrugDiscovery #Virology
(3/3)

Discovery of a new class based on 6-methoxypyrimidine as efficient low weight reversible inhibitors of SARS-CoV-2 main protease (Mpro) with antiviral activity

The main protease Mpro of SARS-CoV-2 is an important enzyme for the viral cycle and its inhibition affects replication and infection propagation. In this way, i

dx.doi.org

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Mike Coston @fla-medic.bsky.social · 9d

AFD Blog `Taiwan CDC Statement On Increased Antiviral #Resistance in Seasonal #H1N1 Cases in 2025' afludiary.blogspot.com/2025/09/taiw...

Taiwan CDC Statement On Increased Antiviral Resistance in Seasonal H1N1 Cases in 2025

Credit NIAID 8,890 While spontaneous `resistance' to oseltamivir (aka ` Tamiflu ') develops in roughly 1%-2% of treated patients, for the ...

afludiary.blogspot.com

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Mike Coston @fla-medic.bsky.social · 13d

AFD Blog `CDC MMWR x 2: Record Pediatric Flu Deaths & Pediatric Influenza-Associated Encephalopathy and Acute Necrotizing Encephalopathy' afludiary.blogspot.com/2025/09/cdc-...

CDC MMWR x 2: Record Pediatric Flu Deaths & Pediatric Influenza-Associated Encephalopathy and Acute Necrotizing Encephalopathy

#18,885 Although the 2024-2025 flu season hasn't quite ended, last winter's influenza-related hospitalizations are reportedly the highest in...

afludiary.blogspot.com

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Greg Folkers @gregfolkers.bsky.social · 14d

Nature: Exclusive: RFK Jr cancelled mRNA research — but the US military / DoD is still funding it

by Elie Dolgin

go.nature.com/3Kl9C8n

Exclusive: RFK Jr cancelled mRNA research — but the US military is still funding it

The Department of Defense is continuing to bankroll projects to develop vaccines against deadly pathogens.

go.nature.com

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Living Safely With Covid @covidsafenz.bsky.social · 14d

Hope so

Reposted by Living Safely With Covid

Josette Schoenmakers @josetteschoenma.bsky.social · 14d

They have started to put PE.1.4, a KP.3.1 sublineage, on the map in New South Wales/Australia.

We have seen it grow in Queensland and New Zealand as well, but it has hardly been seen outside of Oceania.

Will it stay there mostly, like XBC eg. did, or will it conquer the world?

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Living Safely With Covid @covidsafenz.bsky.social · 15d

So far only 21% voted yes. That’s grim.

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Alison Wonderland @sistermaryrc.bsky.social · 15d

I had no idea long covid had surpassed asthma. That is astounding and disturbing. I still have trouble with how some folks just refused to protect others by simply protecting themselves. Just crazy.

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Living Safely With Covid @covidsafenz.bsky.social · 15d

This is the way

Boston schools: Indoor air quality sensors in every classroom and office connected to a ventilation system with monitoring data publicly available.

Clinically Vulnerable Families 💙💜💗 @cvcev.bsky.social · 15d

Boston schools 👏👏👏

Leading the way since 2020. They invested in IAQ sensors in every classroom across the district.

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Living Safely With Covid @covidsafenz.bsky.social · 15d

“No one can escape the impact of poor indoor air quality”@drbronking.bsky.social

Clinically Vulnerable Families 💙💜💗 @cvcev.bsky.social · 15d

"Clean Indoor air is a gap in our public health frameworks. We need to close that gap."

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Clinically Vulnerable Families 💙💜💗 @cvcev.bsky.social · 15d

"Clean air for every child in every classroom is a right, not a privilege."

"This is why for Montenegro, improving air quality in schools is not a secondary concern. It is a fundamental responsibility. A matter of safeguarding the next generation."
👏👏👏

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Clinically Vulnerable Families 💙💜💗 @cvcev.bsky.social · 15d

"We have the tools. What we need now is the collective will to act. To mandate indoor air quality performance standards that effectively reduce the risk of exposure to pathogens and pollutants."

"So accessible indoor air becomes the reality in all public spaces everywhere."

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Living Safely With Covid @covidsafenz.bsky.social · 15d

Incredible moving speech by 20 year old Violet Affleck at the UN today.

Violet listed the harms of infection, pleaded for people to do more to protect children from COVID infections and advocated for masks and for clean filtered indoor air for everyone.

Dr. Lucky Tran @luckytran.com · 15d

“We are told by leaders that we are the future. But when it comes to the ongoing pandemic, our present is being stolen right in front of our eyes.”

Incredible speech by Violet Affleck who warned about the ongoing dangers of COVID & Long Covid, & advocated for masks and clean air at the UN today!

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The Safer Air Project @saferairproject.bsky.social · 17d

“Clean indoor air is one of the lowest-hanging fruits to drive immediate and lasting change. By ensuring the air we breathe indoors is healthy and safe, we can deliver transformative benefits for public health and wellbeing.”

A/Prof Suman Majumdar, Chief Health Officer, Burnet Institute

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Living Safely With Covid @covidsafenz.bsky.social · 15d

Scientist behind Trump’s Tylenol claims was paid $150K to give evidence against drug maker

The Harvard academic Andrea Baccarelli gave an ‘unreliable’ testimony on the links between autism and paracetamol, and produced research that raises ‘serious concerns about bias’

Greg Folkers @gregfolkers.bsky.social · 15d

Times, UK: Scientist behind Trump’s Tylenol claims was paid to give evidence against drug maker

by Samuel Lovett

bit.ly/4nHrad9

Scientist behind Trump’s Tylenol claims was paid to give evidence against drug maker

The Harvard academic Andrea Baccarelli gave an ‘unreliable’ testimony on the links between autism and paracetamol, and produced research that raises ‘serious concerns about bias’

bit.ly

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Living Safely With Covid @covidsafenz.bsky.social · 15d

In animal models an adenovirus-based mucosal booster vaccine was superior to vaccination + prior infection:
- Strongly boosted IgA antibodies in nose & lungs
- Triggered local T-cells in airways
- Provided stronger, longer-lasting protection against SARS-CoV-2.
threadreaderapp.com/thread/19705...

Thread by @vipintukur on Thread Reader App

@vipintukur: It is currently debatable whether mucosal vaccination is still warranted given that most individuals in developed countries have established a hybrid immunity from vaccination and infecti...

threadreaderapp.com

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Greg Folkers @gregfolkers.bsky.social · 15d

Times, UK: Scientist behind Trump’s Tylenol claims was paid to give evidence against drug maker

by Samuel Lovett

bit.ly/4nHrad9

Scientist behind Trump’s Tylenol claims was paid to give evidence against drug maker

The Harvard academic Andrea Baccarelli gave an ‘unreliable’ testimony on the links between autism and paracetamol, and produced research that raises ‘serious concerns about bias’

bit.ly

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Dr Elisa Perego @elisaperego78.bsky.social · 17d

"Unlike classical oncogenic viruses, which transform cells through viral oncogenes or by activating host oncogenes, SARS2 appears to promote tumorigenesis by inhibiting tumor suppressor genes and pathways, while activating survival, proliferation, and inflammation-associated signaling cascades"

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Dr Elisa Perego @elisaperego78.bsky.social · 17d

Oncogenic potential of SARS-CoV-2: "the virus encodes several proteins that alter key signaling pathways associated with cancer hallmarks."

#LongCovid

biosignaling.biomedcentral.com/articles/10....

Oncogenic potential of SARS-CoV-2—targeting hallmarks of cancer pathways - Cell Communication and Signaling

The 2019 outbreak of SARS-CoV-2 has caused a major worldwide health crisis with high rates of morbidity and death. Interestingly, it has also been linked to cancer, which begs the issue of whether it ...

biosignaling.biomedcentral.com

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