@crazysciencelady.bsky.social
Reposted
A study in Nature Communications shows that Zika virus NS1 induces tunneling nanotubes in placental cells, which facilitate viral spread and transport of mitochondria in placental cells. The findings could be used to develop therapeutic strategies targeted against this transmission mode. 🧪
Zika virus NS1 drives tunneling nanotube formation for mitochondrial transfer and stealth transmission in trophoblasts - Nature Communications
Michita et al. show that Zika virus (ZIKV) NS1 induces tunneling nanotubes (TNTs) in placental cells, which facilitate viral spread and transport of mitochondria in placental cells. Infection with a NS1 mutant ZIKV not inducing TNTs results in a higher interferon response than wild-type ZIKV infection.
go.nature.com
March 1, 2025 at 2:32 PM
A study in Nature Communications shows that Zika virus NS1 induces tunneling nanotubes in placental cells, which facilitate viral spread and transport of mitochondria in placental cells. The findings could be used to develop therapeutic strategies targeted against this transmission mode. 🧪
Reposted
RAB-10 cooperates with EHBP-1 to capture vesicular carriers during post-Golgi exocytic trafficking, say Shuai Liu, Jie Wei, Yanling Yan, Anbing Shi and colleagues (Huazhong University of Science and Technology): buff.ly/3QuXAZQ
February 28, 2025 at 7:56 PM
RAB-10 cooperates with EHBP-1 to capture vesicular carriers during post-Golgi exocytic trafficking, say Shuai Liu, Jie Wei, Yanling Yan, Anbing Shi and colleagues (Huazhong University of Science and Technology): buff.ly/3QuXAZQ
Reposted
Now online! HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy
HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy
An upregulation of the HIF2 transcription factor, which is a hallmark of the most common form of human kidney cancer, drives the expression of multiple relatively intact endogenous retroviruses, including some that are presented as HLA-bound peptides that…
dlvr.it
February 28, 2025 at 11:39 PM
Now online! HIF regulates multiple translated endogenous retroviruses: Implications for cancer immunotherapy
Reposted
A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪
Integrating the environmental and genetic architectures of aging and mortality - Nature Medicine
Based on a systematic analysis of environmental exposures associated with aging and mortality in the UK Biobank, the relative contributions of such exposures and genetic risk for mortality and a range of age-related diseases were compared, highlighting the potential beneficial effects of environment-focused interventions.
go.nature.com
March 1, 2025 at 2:34 AM
A study in Nature Medicine provides a comprehensive map of the contributions of environment and genetics to mortality and incidence of common age-related diseases, suggesting that the exposome shapes distinct patterns of disease and mortality risk. #Medsky 🧪
Reposted
Now online! Safeguarding the future of biomedical science in the United States
Safeguarding the future of biomedical science in the United States
NIH’s abrupt decision to cap indirect cost reimbursement at 15% threatens the critical infrastructure supporting groundbreaking biomedical research in the United States. This policy jeopardizes America’s global leadership in science and medicine. Urgent…
dlvr.it
March 1, 2025 at 1:42 PM
Now online! Safeguarding the future of biomedical science in the United States