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Cristina Muñoz Pinedo @crismunozp.bsky.social · 1d

Jaja yes, the fisrt time you’re excited, the resubmission you’re hopeful, the third one …

Cristina Muñoz Pinedo @crismunozp.bsky.social · 2d

Do you guys ever cry after hitting "submit"

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Cristina Muñoz Pinedo @crismunozp.bsky.social · 3d

Killer mTOR
Stress-induced organismal death is genetically regulated by the mTOR–Zeste–Phae1 axis | PNAS www.pnas.org/doi/10.1073/...

Stress-induced organismal death is genetically regulated by the mTOR–Zeste–Phae1 axis | PNAS

All organisms are exposed to various stressors, which can sometimes lead to organismal death, depending on their intensity. While stress-induced or...

www.pnas.org

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Cristina Muñoz Pinedo @crismunozp.bsky.social · 9d

Excellent review in the FEBS Journal (@febsj.bsky.social)
"Emerging roles for integrated stress response signaling in homeostasis"
Shyama Nandakumar, Lydia Grmai, Deepika Vasudevan
febs.onlinelibrary.wiley.com/doi/full/10....

FEBS Press

Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress-adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of l...

febs.onlinelibrary.wiley.com

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Cristina Muñoz Pinedo @crismunozp.bsky.social · 15d

If an alien without epidemiological knowledge was to investigate what causes headache, they would find -by association- that paracetamol and ibuprofen must be the cause
Because their levels are high in people with headache

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Reposted by Cristina Muñoz Pinedo

Mathew Garnett @mgarnett.bsky.social · 19d

The Garnett Lab is excited to launch DepMap Miner, a new tool to explore cancer dependency data!
Built on the Sanger DepMap, the DepMap Miner brings together multi-omic and functional datasets for over 1300 cancer cell models.

Start mining data now: dataminer.depmap.sanger.ac.uk

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Cristina Muñoz Pinedo @crismunozp.bsky.social · 28d

Metabolist: papers on cancer metabolism, August 2025
Highlighted: cachexia
metabolist.wordpress.com/2025/09/05/m...

MetaboList – August 2025

Cancer-associated cachexia Vagal blockade of the brain-liver axis deters cancer-associated cachexia Aliesha Garrett, Naama Darzi, Ashlesha Deshmukh, Nataly Rosenfeld, Omer Goldman, Lital Adler, Eli…

metabolist.wordpress.com

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Cristina Muñoz Pinedo @crismunozp.bsky.social · 28d

Better late than never.
Cancer metabolism: literature from July 2025
(The MetaboList)
Amino acids, lipid metabolism, diet and cancer and more...
metabolist.wordpress.com/2025/09/02/m...

MetaboList – July 2025

Glucose metabolism Glucose-1-phosphate promotes compartmentalization of glycogen with the pentose phosphate pathway in CD8+ memory T cells Yabo Zhou, Chaoying Zhang, Lina He, Youli Kang, Dianheng W…

metabolist.wordpress.com

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Cristina Muñoz Pinedo @crismunozp.bsky.social · Aug 29

You guys think he’s talking about ATF4 and GDF15? Or more about the STING connection

Clay Ranck @clayranck.bsky.social · Aug 27

wtf is this nonsense? He thinks he can understand kid’s “mitochondrial challenges” just by looking at them?

This is an insane person.

Acyn
@Acyn
X.com
RFK JR: I'm looking at kids as I walk through the airports today...and I see these kids that are just overburdened with mitochondrial challenges, inflammation-you can tell from their faces, movements, and lack of social connection

TEXAS "MAKE AMERICA HEALTHY AGAIN" LEGISLATION
ROBERT F. KENNEDY JR.
Health & Human Services Secretary
0:12
From CSPAN
C-SPANG*
15:04 • 8/27/25

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Cristina Muñoz Pinedo @crismunozp.bsky.social · Jul 17

Interesting :-D

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Cristina Muñoz Pinedo @crismunozp.bsky.social · Jul 17

happy birthday ... to me :-)

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Cristina Muñoz Pinedo @crismunozp.bsky.social · Jul 9

She:
Hey! What have you been up to? Have seen you in years!

Me:
Supplementary figure 5, A-Z

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Reposted by Cristina Muñoz Pinedo

DeBerardinis Lab at UT Southwestern Medical Center @rjdlab.bsky.social · Jul 8

Thanks Nature Cancer for the chance to reflect on some factors that led me to study cancer metabolism. For the trainees and other young scientists: the critical events that shape your career might not be obvious while they are happening. Keep an open mind and trust your instincts.

rdcu.be/evi4I

An unexpected career in cancer metabolism

Nature Cancer - Ralph DeBerardinis obtained an MD and PhD from the University of Pennsylvania, then trained in Pediatrics and Medical Genetics at Children’s Hospital of Philadelphia. He moved...

rdcu.be

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Cristina Muñoz Pinedo @crismunozp.bsky.social · Jul 8

🤦‍♀️ so sorry

Cristina Muñoz Pinedo @crismunozp.bsky.social · Jul 3

Interesting articles on cancer metabolism - and ocassionally, just metabolism- published last month
metabolist.wordpress.com/2025/07/03/m...

MetaboList – June 2025

Cystine / Glutathione SLC7A11 is an unconventional H+ transporter in lysosomes Nan Zhou, Jingzhi Chen, Meiqin Hu, Na Wen, Weijie Cai, Ping Li, Liding Zhao, Yaping Meng, Dongdong Zhao, Xiaotong Yang…

metabolist.wordpress.com

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Cristina Muñoz Pinedo @crismunozp.bsky.social · Jul 3

Interested in cell death?
Here's a few interesting papers published last month
celldeath.wordpress.com/2025/07/03/a...

ApoList – June 2025

Bcl-2 family proteins Structural basis of BAX pore formation Ying Zhang, Lu Tian, Gaoxingyu Huang, Xiaofei Ge, Fang Kong, Pengqi Wang, Yige Xu, and Yigong Shi. BH3 mimetics targeting BCL-XL have ef…

celldeath.wordpress.com

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Cristina Muñoz Pinedo @crismunozp.bsky.social · Jul 1

“84% believe climate change is caused by human activity”
Well… the 16% left are very loud!

Ian Hall @ianhall.bsky.social · Jul 1

85% of Europeans Say Tackling Climate Change Should Be a Priority, Eurobarometer Survey Finds

“The cost of damage due to climate change is much higher than the investment needed for a net-zero transition,” agreed 77% of respondents

esgnews.com/amp/85-of-eu...

85% of Europeans Say Tackling Climate Change Should Be a Priority, Eurobarometer Survey Finds

85% of Europeans see climate change as a serious threat and support policies to reach net-zero emissions by 2050.

esgnews.com

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Reposted by Cristina Muñoz Pinedo

Waggoner Lab @labwaggoner.bsky.social · Jul 1

Chemosensor receptors are lipid-detecting regulators of macrophage function in cancer @natimmunol.nature.com @ddimitrilab.bsky.social www.nature.com/articles/s41...

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Reposted by Cristina Muñoz Pinedo

Biomed News @biomednews.bsky.social · Jun 26

We are looking for a new editor for a report on #inflammasome and #infection. You would screen a ranked list of abstracts on this topic. Take a look at the report so far, it has been active for almost 2 years. Let us know if you are interested or have any questions biomed.news/bims-inflin

Inflammasome and infection

biomed.news

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Cristina Muñoz Pinedo @crismunozp.bsky.social · Jun 27

Awch! So many weak/weird results about metabolism and funny forms of cell death published in high impact journals … probably wrong

SLC7A11 is an unconventional H+ transporter in lysosomes: Cell www.cell.com/cell/fulltex...

SLC7A11 is an unconventional H+ transporter in lysosomes

SLC7A11 acts as an unconventional proton exporter in lysosomes regulating proteolytic degradation, ferroptotic cell death, and Parkinson’s disease pathology.

www.cell.com

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Reposted by Cristina Muñoz Pinedo

Matthew Cobb @matthewcobb.bsky.social · Jun 26

Just learned that Frank Stahl (of the Meselson and Stahl DNA replication experiment ("the most beautiful experiment in biology") died at the beginning of April, to no fanfare. Here's a lovely video of them reminiscing: www.youtube.com/watch?v=7-tn...

The Most Beautiful Experiment: Meselson and Stahl

YouTube video by Science Communication Lab

www.youtube.com

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Cristina Muñoz Pinedo @crismunozp.bsky.social · Jun 25

My two cents:
“Coining a new term for a subtype of cell death that clearly fits into an existing category is unwarranted and contributes to creating a scientific tower of Babel where it becomes progressively difficult to know what we are all talking about.”

Autosis: a new addition to the cell death tower of babel - Cell Death & Disease

Cell Death & Disease - Autosis: a new addition to the cell death tower of babel

www.nature.com

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Reposted by Cristina Muñoz Pinedo

Josh Marshall @joshtpm.bsky.social · Jun 17

E.P.A. Plans to Reconsider a Ban on Cancer-Causing Asbestos ¯\_(ツ)_/¯ www.nytimes.com/2025/06/16/u...

E.P.A. Plans to Reconsider a Ban on Cancer-Causing Asbestos

www.nytimes.com

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Cristina Muñoz Pinedo @crismunozp.bsky.social · Jun 7

Esteban Ballestar’s lab studied LPS-driven activation under hypoxia here. They’re more inflammatory, contrary to what was thought
www.science.org/doi/10.1126/...

NF-κB and TET2 promote macrophage reprogramming in hypoxia that overrides the immunosuppressive effects of the tumor microenvironment

Activation under hypoxia boosts immunogenic properties of macrophages with protective potential in cancer.

www.science.org

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Cristina Muñoz Pinedo @crismunozp.bsky.social · Jun 3

Many cool articles in the Metabolist this month.
metabolist.wordpress.com/2025/06/03/m...

MetaboList – May 2025

Glucose and sugars Glycogen drives tumour initiation and progression in lung adenocarcinoma Harrison A. Clarke, Tara R. Hawkinson, Cameron J. Shedlock, Terrymar Medina, Roberto A. Ribas, Lei Wu, Zi…

metabolist.wordpress.com

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