George Caputa
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curiousdrgeorge.bsky.social
George Caputa
@curiousdrgeorge.bsky.social
2.8K followers 37 following 10 posts
senior editor at Nature for cellular & mitochondrial metabolism, metabolic physiology, cardiology, vascular biology, clinical science. All views my own.

nerdy | queer | they/m
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curiousdrgeorge.bsky.social
Both were covered in a great News & Views in @nature.com by Sean Davidson at U Cincinnati

www.nature.com/articles/d41...
The structure of bad cholesterol comes into focus
High-resolution structures of low-density lipoprotein.
www.nature.com
January 9, 2025 at 9:48 AM
curiousdrgeorge.bsky.social
The other by Zach Berndsen and Keith Cassidy took a novel approach by using AF2 and MD to look at how the many beta-sheets dynamically coordinate for different lipoprotein sizes (LDL vs VLDL).

www.nature.com/articles/s41...
The structure of apolipoprotein B100 from human low-density lipoprotein - Nature
Nature - The structure of apolipoprotein B100 from human low-density lipoprotein
www.nature.com
January 9, 2025 at 9:48 AM
curiousdrgeorge.bsky.social
One by Joe Marcotrigiano and colleagues were able to visualize apoB-bound LDL with a ligand-binding domain of the LDLR, giving insight in to the binding and internalization of LDL particles

www.nature.com/articles/s41...
Structure of apolipoprotein B100 bound to the low-density lipoprotein receptor - Nature
Cryo-electron microscopy structures of apolipoprotein B100 (apoB100) in complex with the LDL receptor (LDLR) provide insight into binding interfaces and explain how mutations in apoB100 or in LDLR can...
www.nature.com
January 9, 2025 at 9:48 AM