dadita.bsky.social
David Taborsky
@dadita.bsky.social
140 followers 490 following 3 posts
PhD Student | Developmental Biology | Sendoel Lab @ UZH Working on gastruloids, CRISPR Screens and translational regulation Fascinated by development, regeneration and cancer
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Reposted by David Taborsky
the-node.bsky.social
the Node @the-node.bsky.social · Aug 12
Our latest monthly #preprint list is out!

Have a look at the #DevBio and stem cell biology preprints that came out in July. Congrats to all authors 🎉
thenode.biologists.com/july-in-prep...
July in preprints - the Node
Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv.
thenode.biologists.com
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dadita.bsky.social
David Taborsky @dadita.bsky.social · Aug 6
If you are interested in #DevBio, #organoids, #gastruloids or #CRISPR, check out the tweetorial to our new preprint on uncovering novel regulators of body plan formation in gastruloids using single cell CRISPR screens!

A big thank you to all co-authors that made this paper possible!
sendoellab.bsky.social
Sendoel Lab @sendoellab.bsky.social · Aug 6
The establishment of the body plan during gastrulation is a hallmark of animal life, yet much of its regulation remains unclear. Here, we combine gastruloids and single-cell CRISPR screenings to uncover new regulators of the body plan.

www.biorxiv.org/content/10.1...
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dadita.bsky.social
David Taborsky @dadita.bsky.social · Jul 25
How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!
biorxiv-devbio.bsky.social
bioRxiv Developmental Biology @biorxiv-devbio.bsky.social · Jul 22
Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids https://www.biorxiv.org/content/10.1101/2025.07.22.666114v1
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dadita.bsky.social
David Taborsky @dadita.bsky.social · May 28
Check out this cool new preprint from our lab! Congratulations to @merveyigit.bsky.social, the hard work paid off! 🥳
sendoellab.bsky.social
Sendoel Lab @sendoellab.bsky.social · May 26
Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x

www.biorxiv.org/content/10.1...
The alternative initiation factor eIF2A regulates 40S subunit turnover in ribosome-associated quality control
The noncanonical translation initiation factor eIF2A plays critical roles in diverse cellular processes, including the integrated stress response, neurodegeneration and tumorigenesis. However, the pre...
www.biorxiv.org
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Reposted by David Taborsky
sendoellab.bsky.social
Sendoel Lab @sendoellab.bsky.social · Mar 19
Our genome encodes > 7000 microproteins that have been previously ignored in genome annotations. How do these microproteins impact tissue function? Here, we use an in vivo single-cell CRISPR screen to systematically explore microprotein function in the mouse epidermis. 1/9
www.biorxiv.org
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Reposted by David Taborsky
claradure.bsky.social
Clara Duré @claradure.bsky.social · Nov 19
I'm thrilled to share the latest pre-print from our lab. An in vivo single-cell ribosome profiling study investigating the translational landscape of aging skin.
#aging #single-cell #Ribo-sea
sendoellab.bsky.social
Sendoel Lab @sendoellab.bsky.social · Nov 18
How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse epidermis 1/6

www.biorxiv.org/content/10.1...
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