dairegannon.bsky.social
@dairegannon.bsky.social
32 followers 39 following 3 posts
Postdoctoral researcher at WEHI
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dairegannon.bsky.social
dairegannon.bsky.social @dairegannon.bsky.social · May 21
Our work identifying CBX4 as a potential therapeutic target for diffuse midline glioma has just been published in Molecular Cell! Check out co-first author @eimearlagan.bsky.social’s overview below.
eimearlagan.bsky.social
Eimear Lagan @eimearlagan.bsky.social · May 21
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
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dairegannon.bsky.social
dairegannon.bsky.social @dairegannon.bsky.social · Jun 7
Thanks Jongmin!
dairegannon.bsky.social
dairegannon.bsky.social @dairegannon.bsky.social · Jun 6
Great to see @jongminkmg.bsky.social’s preview of our work in @cp-molcell.bsky.social today!
www.cell.com/molecular-ce...
Not all CBXs are created equal: A role for the disordered central region of CBX4 in pediatric glioma
In this issue, Lagan et al.1 apply genome-wide and tiling-scan CRISPR screens to uncover a key role for CBX4 and its central region in promoting the growth of diffuse midline glioma cells bearing the ...
www.cell.com
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Reposted
cp-molcell.bsky.social
Molecular Cell @cp-molcell.bsky.social · May 21
Online Now: A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma Online now:
A specific form of cPRC1 containing CBX4 is co-opted to mediate oncogenic gene repression in diffuse midline glioma
Lagan, Gannon, et al. reveal that H3K27M-DMGs depend on a specific form of cPRC1 containing CBX4 and PCGF4. H3K27M alters H3K27me3 distribution, causing increased binding of CBX4-PCGF4-cPRC1 and oncogenic gene repression. CBX4’s ability to read H3K27me3 and to form a specific cPRC1 complex with PCGF4 makes it essential in DMG.
dlvr.it
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dairegannon.bsky.social
dairegannon.bsky.social @dairegannon.bsky.social · May 21
Our work identifying CBX4 as a potential therapeutic target for diffuse midline glioma has just been published in Molecular Cell! Check out co-first author @eimearlagan.bsky.social’s overview below.
eimearlagan.bsky.social
Eimear Lagan @eimearlagan.bsky.social · May 21
Excited to share our new paper out today in @cp-molcell.bsky.social! We show that the H3K27M oncohistone rewires cPRC1, creating a unique dependency on CBX4/PCGF4-containing complexes, and also reveal a previously unknown function of CBX4. Highlights below (1/11).
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