Published today in Cell Chemical Biology, our Cryo-EM structure of PP2A/B55α with IER5 and identification of IER5 structural homologues SERTADs using structural bioinformatics. Congratulations to Aster and @blacklowlab.bsky.social authors!

www.sciencedirect.com/science/arti...

Great to see our work on protein phosphatase 2A (PP2A) and IER5 featured in a recent review by Peti and Page labs. Particular focus on our work identifying structural homology between IER and SRTD proteins using a conserved alpha helical hairpin motif. www.sciencedirect.com/science/arti...

Cuts in NIH research grants will have a lasting negative impact on science and medicine in the U.S. Grants will continue to fund specific research costs, but essential infrastructure like labs, advanced equipment and support staff are crucial for groundbreaking work.

Online @cellpress.bsky.social, we reveal a protein shell that helps diatoms fix 20% of global #CO2 🧪🌊🌾🧶🧬🌍

Shimakawa et al:
www.cell.com/cell/fulltex...

Nam et al:
www.cell.com/cell/fulltex...

@biozentrum.bsky.social press release:
www.biozentrum.unibas.ch/news/detail/...

Read on for more...
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Yes please!

Diving into Rosetta this Sunday morning with a mutation scan and a coffee.

It’s nice to have a feed filled with science rather than all that other stuff. Hope it stays that way.

Earlier this year we published functional profiles of all 33 adhesion GPCRs in signalling/biosensor assays. Led by recently graduated Drew Dates, we found a dichotomy of tethered agonist dependent and independent receptors.
www.sciencedirect.com/science/arti...

Our recent story on the mechanism of PP2A/B55 inhibition by IER5 - a notch target gene essential for keratinocyte differentiation in squamous cell carcinoma cells. We use functional assays, biochemistry and Cryo-EM to determine the molecular mechanism www.biorxiv.org/content/10.1...