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Daniel Grint

@danieljgrint.bsky.social

86 followers 120 following 69 posts

Associate Prof of Medical Statistics @lshtm.bsky.social | TB and HIV treatment trialist | Electronic health records analyst | Running shoe geek

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Daniel Grint @danieljgrint.bsky.social · Mar 15

It was a pleasure working with @tomayates.bsky.social on this comment in @lancetmicrobe.bsky.social
It's time for new TB treatment trials to use a more focused primary outcome definition, moving on from the composite outcome that has prevailed for the last decade

www.thelancet.com/journals/lan...

Primary efficacy endpoints in phase 3 non-inferiority trials to establish new tuberculosis treatment regimens should only include microbiological outcomes

Treatment regimens for tuberculosis remain protracted and burdensome, both for patients to adhere to and for health-care providers to administer. Particularly, many current regimens for drug-resistant...

www.thelancet.com

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Reposted by Daniel Grint

Rein Houben @reinhouben.bsky.social · 1d

In a new preprint (NOT PEER REVIEWED) we continue to explore the challenge of overtreatment in community screening. It seems the benefits of TB treatment far outweigh the harms, especially once we accept that sputum culture is not perfect. Important food for thought. www.medrxiv.org/content/10.1...

Do no harm - re-evaluating the risks of overtreatment in community-wide tuberculosis screening

Background Community-wide screening is a crucial strategy to end tuberculosis (TB), but a common concern is potential harm from overtreatment following false positive diagnoses. However, current refer...

www.medrxiv.org

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Daniel Grint @danieljgrint.bsky.social · 8d

For this reason the combination of Xpert CT and a detailed CXR examination seems to be best at identifying those who may relapse post treatment.

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Daniel Grint @danieljgrint.bsky.social · 8d

They may all represent seperate pathways, except smear and CT which intuitively may be related based on sputum. The great benefit of Xpert CT is the automatic readout with no need for reader interpretation. I imagine much of the variability in culture/smear comes from the operator.

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Daniel Grint @danieljgrint.bsky.social · 8d

Correlations between CT, culture and CXR were weak, it's only smear that was reasonably correlated with CT. Smear and culture were weakly correlated with each other (R^2 14%), but neither correlated with CXR (both R^2 <10%).

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Daniel Grint @danieljgrint.bsky.social · 8d

Hi Gabriele
Ultra is worse than Xpert at differentiating between the higher levels of disease severity. The study population was skewed towards a higher degree of disease severity, which may explain the lack of correlation between Ultra and CXR.

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Reposted by Daniel Grint

Clinical Infectious Diseases @cidjournal.bsky.social · 10d

Xpert MTB/RIF® cycle threshold as a marker of TB disease severity; Implications for TB treatment stratification

✅ Just Accepted
#IDSky
🔗 https://bit.ly/3WbLI1G

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Daniel Grint @danieljgrint.bsky.social · 13d

Push to main.

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Daniel Grint @danieljgrint.bsky.social · 13d

This paper has now been peer reviewed and is available open access at CID.

Daniel Grint @danieljgrint.bsky.social · 15d

apropos of nothing

Acetaminophen Use During Pregnancy and Children’s Risk of Autism, ADHD, and Intellectual Disability

This nationwide cohort study with sibling control analysis examines the association of acetaminophen use during pregnancy with children’s risk of autism, ADHD, and intellectual disability.

jamanetwork.com

Reposted by Daniel Grint

Matthew Saunders @mjsaunder.bsky.social · 29d

Nutritional status is a key determinant of TB. In this updated systematic review and dose-response meta-analysis (43 cohorts inc > 26 million people) we redefined the relationship between body mass index (BMI) and TB. doi.org/10.1093/ije/...

Body mass index and tuberculosis risk: an updated systematic literature review and dose–response meta-analysis

AbstractBackground. The relationship between nutritional status and tuberculosis is critically important but poorly understood. We extended a 2009 review c

doi.org

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Reposted by Daniel Grint

Katherine Horton @kchorton.bsky.social · Sep 5

At a time when global resources for #TB research, development, prevention, and care are limited, which interventions should be prioritised in high burden settings?

📢 Our new pre-print compares the impact, cost, and cost-effectiveness of 9 TB interventions in 3 countries. 1/n

bit.ly/3V3vXth

The potential impact, cost and cost-effectiveness of tuberculosis interventions - a modelling exercise

Background While a range of interventions exist for tuberculosis prevention, screening, diagnosis, and treatment, their potential population impact and cost-effectiveness are seldom directly compared,...

bit.ly

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Daniel Grint @danieljgrint.bsky.social · Sep 3

"Nobody suspects the dishwasher" sticks in memory from a previous round I attended somewhere.

Reposted by Daniel Grint

Alexander Luckmann @aluckmann.bsky.social · Aug 20

Academia may not give you job security, flexibility, or wealth, but it will let you unexpectedly connect to eduroam in foreign cities

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Reposted by Daniel Grint

Emily Hunt @emily.space · Aug 15

I really dislike how science has started calling almost any fancy computational technique AI. 🧪

The framing of this entire article makes it sound like a benevolent AI independently made these drugs.

That is *pure fantasy*.

Instead: a team of scientists made a machine learning model for a study.

Article on BBC news.
Title: AI designs antibiotics for gonorrhoea and MRSA superbugs
Description: Two new potential drugs have been designed by AI to kill drug-resistant bacteria, in a major Massachusetts Institute of Technology study.

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Daniel Grint @danieljgrint.bsky.social · Jul 18

p.s. I've been consistently spelling injectAble wrong for 3+ years now.

Reposted by Daniel Grint

Peter MacPherson @petermacp.bsky.social · May 1

⚡️New preprint (not peer-reviewed)⚡️

In the SaDAPT trial with people with #HIV and #tuberculosis symptoms in 🇲🇼🇱🇸, we investigated if antiretroviral therapy should be initiated immediately, or delayed until TB results available. ssrn.com/abstract=523...

Outcomes (incl. IRIS) similar across both arms.

The front page of the preprint article, showing title and authors

Forest plot showing primary and secondary trial outcomes, with non-inferiority margins

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Daniel Grint @danieljgrint.bsky.social · Jul 18

Delighted to see our long-acting injectible ART trial (IMPALA) presented at #IAS2025. 2-monthly injections are non-inferior to daily pill taking and overwhelmingly preferred. Next challenge is expanding access to LA ART; excellent news the WHO has recommended LA CAB+RPV in treatment guidelines.

aidsmap @aidsmap.bsky.social · Jul 18

News from #IAS2025: Injectable HIV treatment works for people with poor HIV control in Africa
www.aidsmap.com/news/jul-2025/injectable-hiv-treatment-works-people-poor-hiv-control-africa
@iasociety.bsky.social

Injectable HIV treatment works for people with poor HIV control in Africa

Injectable treatment with long-acting cabotegravir and rilpivirine is as effective as dolutegravir-based oral treatment in adults with HIV in sub-Saharan Africa who have a history of treatment non-adh...

www.aidsmap.com

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Daniel Grint @danieljgrint.bsky.social · Jul 18

Yeah, that part could definitely be better written. 10% mortality reduction is impressive!

Daniel Grint @danieljgrint.bsky.social · Jul 17

Interpretation beyond that is for the reader. It's possible these results could still change guidelines.

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Daniel Grint @danieljgrint.bsky.social · Jul 17

I think you'd probably be right to, assuming there are no potential ill effects. 'Statistical significant' i.e. <0.05 is less of a thing now, but you still have to respect the study design. In this case, they just missed the pre-defined superiority criteria and must report on those lines.

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Daniel Grint @danieljgrint.bsky.social · Jul 17

You don't need a Bayesian analysis to be less rigid in interpreting p- values. You're right the result looks promising, but it requires further study.

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Daniel Grint @danieljgrint.bsky.social · Jul 5

Mandating culture/PCR for everyone in a vaccine trial makes sense to me, I didn't realise that wasn't the case. But it could (likely will) end up costing more even if the sample size is lower.

Daniel Grint @danieljgrint.bsky.social · Jul 5

Very interesting. In TB treatment trials, it's standard practice to test culture from everyone every few months regardless of symptoms. Consecutive positives define TB relapse without worrying about symptoms. However, this is a big cost driver!!!

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Daniel Grint @danieljgrint.bsky.social · Jul 5

Describing the hawkeye automated line calling at Wimbledon as 'AI' can seriously get in the sea.

Daniel Grint @danieljgrint.bsky.social · Jun 26

add 10% to the quote you see when shopping around is my philosophy once it's been through the booking agent