Dan Worthley
@danworthley.bsky.social
Gastroenterologist @ Colonoscopy Clinic | Cancer scientist | Dad & husband | Enthusiastic (but appalling) runner | MBBS (Hons), PhD, MPH, FRACP, AGAF |
Hear directly from lead author Ludmil B. Alexandrov: lnkd.in/ekg6yKeJ
#EOCRC #Never2Young #ColorectalCancer #Microbiome #GutHealth
Please follow for the Coolest Thing in Microbial Medicine each week!
#EOCRC #Never2Young #ColorectalCancer #Microbiome #GutHealth
Please follow for the Coolest Thing in Microbial Medicine each week!
You know the recent spike in colorectal cancer in people under 50…what’s… | Albert "Al" P. Pisano, Ph.D.
You know the recent spike in colorectal cancer in people under 50…what’s the cause? There are new insights in a Nature paper out today. The paper discusses mutations to colon cells early in life that ...
lnkd.in
April 26, 2025 at 3:59 AM
Hear directly from lead author Ludmil B. Alexandrov: lnkd.in/ekg6yKeJ
#EOCRC #Never2Young #ColorectalCancer #Microbiome #GutHealth
Please follow for the Coolest Thing in Microbial Medicine each week!
#EOCRC #Never2Young #ColorectalCancer #Microbiome #GutHealth
Please follow for the Coolest Thing in Microbial Medicine each week!
TAKE-HOME 2: Emerging solutions include microbiome diagnostics and therapies targeting these bacteria (faecal metagenomic sequencing, diet, probiotics, bacteriophages, vaccines).
Until EOCRC risk is better understood and managed, we should advocate lowering the screening age to 40.
Until EOCRC risk is better understood and managed, we should advocate lowering the screening age to 40.
April 26, 2025 at 3:57 AM
TAKE-HOME 2: Emerging solutions include microbiome diagnostics and therapies targeting these bacteria (faecal metagenomic sequencing, diet, probiotics, bacteriophages, vaccines).
Until EOCRC risk is better understood and managed, we should advocate lowering the screening age to 40.
Until EOCRC risk is better understood and managed, we should advocate lowering the screening age to 40.
TAKE-HOME 1: Childhood colonisation by colibactin-producing bacteria may fundamentally alter lifelong colorectal cancer risk, particularly for early-onset cases.
Detection of these specific mutational signatures in normal mucosa could enable early risk stratification.
Detection of these specific mutational signatures in normal mucosa could enable early risk stratification.
April 26, 2025 at 3:56 AM
TAKE-HOME 1: Childhood colonisation by colibactin-producing bacteria may fundamentally alter lifelong colorectal cancer risk, particularly for early-onset cases.
Detection of these specific mutational signatures in normal mucosa could enable early risk stratification.
Detection of these specific mutational signatures in normal mucosa could enable early risk stratification.
FUTURE RESEARCH NEEDED: Adolescent microbiome analyses linking bacterial colonization with later cancer risk
Animal models testing preventive strategies
Identifying other mutagens contributing to early-onset cases.
Animal models testing preventive strategies
Identifying other mutagens contributing to early-onset cases.
April 26, 2025 at 3:55 AM
FUTURE RESEARCH NEEDED: Adolescent microbiome analyses linking bacterial colonization with later cancer risk
Animal models testing preventive strategies
Identifying other mutagens contributing to early-onset cases.
Animal models testing preventive strategies
Identifying other mutagens contributing to early-onset cases.
KEY FINDING: These signatures appeared without active bacterial colonization, suggesting early-life exposure creates DNA "scarring" that increases lifelong cancer risk.
The mutations affected critical colorectal cancer driver genes.
The mutations affected critical colorectal cancer driver genes.
April 26, 2025 at 3:54 AM
KEY FINDING: These signatures appeared without active bacterial colonization, suggesting early-life exposure creates DNA "scarring" that increases lifelong cancer risk.
The mutations affected critical colorectal cancer driver genes.
The mutations affected critical colorectal cancer driver genes.
NEW DISCOVERY: UC San Diego researchers sequenced 802 colorectal cancer cases, finding colibactin-associated signatures were significantly higher in patients diagnosed <50 years of age.
Younger patients showed more colibactin-induced mutations.
Younger patients showed more colibactin-induced mutations.
April 26, 2025 at 3:54 AM
NEW DISCOVERY: UC San Diego researchers sequenced 802 colorectal cancer cases, finding colibactin-associated signatures were significantly higher in patients diagnosed <50 years of age.
Younger patients showed more colibactin-induced mutations.
Younger patients showed more colibactin-induced mutations.
BACKGROUND: Colibactin is a genotoxin produced by certain E. coli bacteria that introduces distinct DNA mutations.
Previous studies validated colibactin's role in creating detectable genomic "mutational signatures" (SBS88 and ID18).
Previous studies validated colibactin's role in creating detectable genomic "mutational signatures" (SBS88 and ID18).
April 26, 2025 at 3:53 AM
BACKGROUND: Colibactin is a genotoxin produced by certain E. coli bacteria that introduces distinct DNA mutations.
Previous studies validated colibactin's role in creating detectable genomic "mutational signatures" (SBS88 and ID18).
Previous studies validated colibactin's role in creating detectable genomic "mutational signatures" (SBS88 and ID18).
STATS: Millennials (born ~1990) have a 2.4× higher risk of colon cancer and 4.3× higher risk of rectal cancer compared to Baby Boomers (born ~1950).
But why is this happening?
But why is this happening?
April 26, 2025 at 3:52 AM
STATS: Millennials (born ~1990) have a 2.4× higher risk of colon cancer and 4.3× higher risk of rectal cancer compared to Baby Boomers (born ~1950).
But why is this happening?
But why is this happening?
THE ISSUE: As a gastroenterology trainee 20 years ago, early-onset colorectal cancer cases were rare and mostly familial.
Now, diagnoses in young, healthy patients without family histories are unnervingly common.
Now, diagnoses in young, healthy patients without family histories are unnervingly common.
April 26, 2025 at 3:52 AM
THE ISSUE: As a gastroenterology trainee 20 years ago, early-onset colorectal cancer cases were rare and mostly familial.
Now, diagnoses in young, healthy patients without family histories are unnervingly common.
Now, diagnoses in young, healthy patients without family histories are unnervingly common.