Dan Worthley
@danworthley.bsky.social
Gastroenterologist @ Colonoscopy Clinic | Cancer scientist | Dad & husband | Enthusiastic (but appalling) runner | MBBS (Hons), PhD, MPH, FRACP, AGAF |
Medicine shifts overnight.
15% of CRCs are dMMR.
Surgery was standard—until now.
Diaz, Cercek @mskcancercenter.bsky.social @nejm.org: dostarlimab = 82% CR, 92% RFS, low toxicity.
Immunotherapy first. Surgery backup.
Paper: nejm.org/doi/full/10.1056/NEJMoa2404512
#Lynch #CRC #Immunotherapy
15% of CRCs are dMMR.
Surgery was standard—until now.
Diaz, Cercek @mskcancercenter.bsky.social @nejm.org: dostarlimab = 82% CR, 92% RFS, low toxicity.
Immunotherapy first. Surgery backup.
Paper: nejm.org/doi/full/10.1056/NEJMoa2404512
#Lynch #CRC #Immunotherapy
Nonoperative Management of Mismatch Repair–Deficient Tumors | NEJM
Among patients with mismatch repair–deficient (dMMR), locally advanced rectal cancer,
neoadjuvant checkpoint blockade eliminated the need for surgery in a high proportion
of patients. Whether this ...
nejm.org
April 27, 2025 at 9:57 PM
Medicine shifts overnight.
15% of CRCs are dMMR.
Surgery was standard—until now.
Diaz, Cercek @mskcancercenter.bsky.social @nejm.org: dostarlimab = 82% CR, 92% RFS, low toxicity.
Immunotherapy first. Surgery backup.
Paper: nejm.org/doi/full/10.1056/NEJMoa2404512
#Lynch #CRC #Immunotherapy
15% of CRCs are dMMR.
Surgery was standard—until now.
Diaz, Cercek @mskcancercenter.bsky.social @nejm.org: dostarlimab = 82% CR, 92% RFS, low toxicity.
Immunotherapy first. Surgery backup.
Paper: nejm.org/doi/full/10.1056/NEJMoa2404512
#Lynch #CRC #Immunotherapy
COOLEST THING IN MICROBIAL MEDICINE THIS WEEK 🔬🧫
New research in Nature suggests early-onset colorectal cancer (EOCRC) might be increasing due to childhood colonisation by colibactin-producing bacteria.
A thread on this fascinating discovery... 🧵
#MicrobialMedicine
New research in Nature suggests early-onset colorectal cancer (EOCRC) might be increasing due to childhood colonisation by colibactin-producing bacteria.
A thread on this fascinating discovery... 🧵
#MicrobialMedicine
April 26, 2025 at 3:51 AM
COOLEST THING IN MICROBIAL MEDICINE THIS WEEK 🔬🧫
New research in Nature suggests early-onset colorectal cancer (EOCRC) might be increasing due to childhood colonisation by colibactin-producing bacteria.
A thread on this fascinating discovery... 🧵
#MicrobialMedicine
New research in Nature suggests early-onset colorectal cancer (EOCRC) might be increasing due to childhood colonisation by colibactin-producing bacteria.
A thread on this fascinating discovery... 🧵
#MicrobialMedicine
Reposted by Dan Worthley
“Back then, the overwhelming public sentiment was: never again. Today, it seems: never what?”—Siddhartha Mukherjee
Exceptional essay
Gift link
www.nytimes.com/2025/03/10/o...
Exceptional essay
Gift link
www.nytimes.com/2025/03/10/o...
Opinion | Covid’s Deadliest Effect Took Five Years to Appear (Gift Article)
What once belonged to all of us now belongs to corporations.
www.nytimes.com
March 16, 2025 at 3:58 PM
“Back then, the overwhelming public sentiment was: never again. Today, it seems: never what?”—Siddhartha Mukherjee
Exceptional essay
Gift link
www.nytimes.com/2025/03/10/o...
Exceptional essay
Gift link
www.nytimes.com/2025/03/10/o...