The Open Targets Platform autumn release is out! 🍂

We have ingested the full dataset of over 13 million enhancer-gene regulatory interactions in the human genome across 1,458 DNase-seq experiments covering 369 cell types and tissues from the ENCODE-rE2G model

blog.opentargets.org/open-targets...

🧬 New @emblebi.bsky.social service beta launched:
Perturbation Catalogue

🔎 Browse genetic perturbation datasets
🧠 Train models
🧬 Interpret variant function
🧭 Explore gene dependencies

Search, test APIs, suggest datasets, send feedback!
🔗 www.ebi.ac.uk/perturbation...

Funded by @opentargets.org

Open Targets Platform 25.06 is out now! 🌻

It includes 36% more GWAS credible sets (including from the VA Million Veteran Program study) and a new target interactors view to help nominate potential targets

blog.opentargets.org/open-targets...

Very excited to share the latest work of the team @opentargets.org. If you are interested in #targetdiscovery and #genetics check out the latest release of the Open Targets Platform.

What can we learn from 95 projects across 10 years of industry-academic collaboration? 🤝

In a comment for Nature Reviews Drug Discovery, the Open Targets Directors shared their insights on what makes a successful and impactful project 🧪🧬

www.nature.com/articles/d41...

We're hiring! 👩‍🔬🧬💻

➡ Staff Scientist: high-throughput sc CRIPSR screening in neurodegenerative disease

➡ Data Manager (part time), the point of contact for Open Targets project data

➡ Postdoc: Neurodegenerative Disease Immune Response Modelling

opentargets.org/jobs

#neurojobs #sciencejobs

With the gget opentargets module, you can now interact directly with the Open Targets database from a Python or command line environment

Developed by @lauraluebbert.com, gget is a free, open-source tool enabling efficient querying of large genomic databases 🖥️🧬

blog.opentargets.org/case-study-g...

🗞️New preprint!

Maria Falaguera developed a method to comprehensively track the accumulation of literature-derived, genetic and clinical evidence linking targets to disease over time, and to identify novel drug target opportunities

🧬🖥️

www.researchsquare.com/article/rs-5...