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David Konrad

@dbkonrad.bsky.social

1.5K followers 1K following 59 posts

Tenure-Track Professor @univie.ac.at & Research Group Leader @lmumuenchen.bsky.social. Cancer Chemical Biology, (Chemo)Proteomics, Medicinal Chemistry and Chemical Methology Development. #newPI | #FirstGen Homepage: https://konrad.cup.uni-muenchen.de

konrad.cup.uni-muenchen.de

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Reposted by David Konrad

Huber Lab @ RU Bochum @shuberlab.bsky.social · 6d

Please check this announcement for an early-career group leader, hosted jointly by our cluster of excellence RESOLV and the MPI Kofo. The thematic focus should be on catalysis: jobs.ruhr-uni-bochum.de/jobposting/4...

Early Career Research (ECR) Group Leader position (m/f/d) with the thematic focus on “Catalysis” within the Cluster of Excellence RESOLV

jobs.ruhr-uni-bochum.de

Reposted by David Konrad

Andreas Linkermann @linkermannlab.bsky.social · Aug 19

Happy to start at Bluesky with a post on our recent manuscript at @nature.com:

www.nature.com/articles/s41...

Great collaboration with cool scientists such as @theprattgroup.bsky.social, @fedorovalab.bsky.social and many who do not (yet) have a Bluesky account.

Multiple oestradiol functions inhibit ferroptosis and acute kidney injury - Nature

17β-oestradiol establishes an anti-ferroptotic state in female kidney tubules.

David Konrad @dbkonrad.bsky.social · Aug 7

Love the concept!!

David Konrad @dbkonrad.bsky.social · Jun 26

Same 😊

David Konrad @dbkonrad.bsky.social · Jun 18

Big thanks to our co-authors from academia: @fragrisoni.bsky.social, @dirktrauner.bsky.social, Marcel Bermudez and from industry: Marcel Mülbaier and Clemens Dialer (Grünenthal GmbH).

David Konrad @dbkonrad.bsky.social · Jun 18

Here, we discuss the potential for the development of analgesics, structure-activity relationships on NaV channels, biosynthetic hypotheses and chemical syntheses.

David Konrad @dbkonrad.bsky.social · Jun 18

It is a great pleasure to share that our extensive review on "The Chemistry and Biology of the Tetrodotoxin Natural Product Family" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie....

David Konrad @dbkonrad.bsky.social · Jun 4

But that is not all! To showcase the potential of dfdc azobenzenes for the development of chemical tools, we synthesized dfdc-OptoBI-1 and demonstrated its biological activity as a red light-operated activator of TRPC6 channels in HEK293 cells.

David Konrad @dbkonrad.bsky.social · Jun 4

The data was used to establish a computational approach that allows to compute realistic UV-vis spectra by combining TD-DFT excited-state calculations with MD simulations. As such, our combined experimental and computational study enables the in silico design of new highly red-shifted photoswitches.

David Konrad @dbkonrad.bsky.social · Jun 4

In total, we have added 15 new visible light-operated photoswitches to the toolbox for the development of optical devices with relaxation rates across multiple orders of magnitudes and identified several examples with stronger bathochromic shifts than the dfdc azobenzene lead structure.

David Konrad @dbkonrad.bsky.social · Jun 4

We have developed synthetic protocols for a variety of derivatives of the dfdc (di-ortho-fluoro-di-ortho-chloro) azobenzene scaffold and performed an in-depth study into their photophysical properties using NMR, UV-vis and X-ray analysis.

David Konrad @dbkonrad.bsky.social · Jun 4

I am incredibly excited that our manuscript: "A Platform for the Development of Highly Red-Shifted Azobenzene-based Optical Tools" has been accepted for publication at Angewandte Chemie: doi.org/10.1002/anie... 🤩

David Konrad @dbkonrad.bsky.social · May 14

We are looking for a PhD candidate in medicinal / organic chemistry with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: jobs.univie.ac.at/job/Universi.... Reposts are very much appreciated!

Reposted by David Konrad

15th International ABPP Meeting @abpp2027.bsky.social · Apr 23

We are very excited that we will be hosting the 15th International Activity Based Protein Profiling (ABPP) Meeting in Leiden in 2027. If you do not want to miss anything, make sure to follow this page to see all the information in the future.

David Konrad @dbkonrad.bsky.social · Apr 7

📢 Only one more week to apply!

David Konrad @dbkonrad.bsky.social · Mar 21

We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: vds-phanuspo.univie.ac.at/application/.... Reposts are very much appreciated!

David Konrad @dbkonrad.bsky.social · Mar 21

We are looking for a PhD candidate in molecular biology / biochemistry / chemical biology with a passion for drug discovery to join our young and enthusiastic team @univie.ac.at. For details, visit: vds-phanuspo.univie.ac.at/application/.... Reposts are very much appreciated!

Reposted by David Konrad

Alexander Bartelt @barteltlab.bsky.social · Mar 14

We have a new homepage @tum.de including The Hall of Fame of Graduates - check it out!
👇
www.mls.ls.tum.de/tnm

Wir verwenden Google für unsere Suche. Mit Klick auf „Suche aktivieren“ aktivieren Sie das Suchfeld und akzeptieren die Nutzungsbedingungen.

www.mls.ls.tum.de

David Konrad @dbkonrad.bsky.social · Mar 3

So cool! 🤩

Huber Lab @ RU Bochum @shuberlab.bsky.social · Mar 3

The combined power of halogen bonding and asymmetric counteranion-directed catalysis = XB-ACDC: pubs.acs.org/doi/10.1021/.... Thanks to @mertenlab.bsky.social for structure elucidation and to the List group for this beautiful cooperation! A perfect #RESOLV project! @solvationsci.bsky.social

Asymmetric Counteranion-Directed Halogen Bonding Catalysis

Halogen bonding has been established as a promising tool in organocatalysis. Asymmetric processes are nevertheless scarce, and their applications are limited to a few studies applying chiral halogen b...

Reposted by David Konrad

Ivan Huc Group @akhuc.bsky.social · Feb 27

Please check out our Angew. communication on DNA mimic foldamers that can outcompete DNA itself in the binding of proteins! 🧬

onlinelibrary.wiley.com/doi/full/10....

DNA Mimic Foldamer Recognition of a Chromosomal Protein

Biomolecular mimics are intended to outperform their natural counterparts. However, B-DNA surface mimicry to target DNA-binding proteins has long remained underdeveloped. We have introduced helical a...

onlinelibrary.wiley.com

Reposted by David Konrad

The Onion @theonion.com · Feb 21

DOGE By The Numbers
theonion.com/doge-by...

Reposted by David Konrad

RedOx@DKFZ @redoxdkfz.bsky.social · Feb 20

A surprise finding with interesting chemistry: protein bound zinc ions can activate Proton Pump Inhibitors (PPIs)

Thanks to a great collaboration with @aubrykmiller.bsky.social and many colleagues!

www.nature.com/articles/s41...

David Konrad @dbkonrad.bsky.social · Feb 18

Thanks Ivana!

David Konrad @dbkonrad.bsky.social · Feb 18

Thanks Johannes!

David Konrad @dbkonrad.bsky.social · Feb 18

Managing to score a professorship without a Cell, Science or Nature paper.

David Konrad @dbkonrad.bsky.social · Feb 18

When grant writing is become so intense that you need to procrastinate a little by posting on #ChemSky.