Daniela C. Soto
@dcsoto.bsky.social
67 followers 50 following 5 posts
Postdoctoral scholar at UCSB. HHMI Hanna Gray Fellow. Human brain evolution. Long-read sequencing enthusiast. dcsoto.github.io
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Reposted by Daniela C. Soto
klohmueller.bsky.social
Come join us at UCLA!!! We have a growing population genetics community here and Nandita and her lab are outstanding!
nanditagarud.bsky.social
I am seeking a postdoc for my group at UCLA. We work at the intersection of population genetics x microbiome (garud.eeb.ucla.edu). If interested, please message me!
Garud Lab
garud.eeb.ucla.edu
Reposted by Daniela C. Soto
aidaandres.bsky.social
Outstanding work by @dcsoto.bsky.social @jmuribescr.bsky.social @mydennis.bsky.social (and other collaborators) that massively advances identification of human gene duplicates, with links to important traits and our evolution. So happy to have contributed a bit to this fantastic paper.
mydennis.bsky.social
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
authors.elsevier.com
Reposted by Daniela C. Soto
pacbio.bsky.social
Landmark study using #PacBio #HiFiSequencing reveals human-specific genetic variation not detectable with short reads. Researchers uncover new insights into brain evolution and potential links to cognition and autism.

Read the full paper: bit.ly/3IxQtPR

#BrainResearch
Human-specific gene expansions contribute to brain evolution
A complete human genome and functional modeling in zebrafish pinpoint gene expansions that may underlie the evolutionary innovations of the human brain.
bit.ly
Reposted by Daniela C. Soto
jmuribescr.bsky.social
Thrilled to see this story out today! Such a fascinating topic with lots still to discover 🥳
mydennis.bsky.social
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
authors.elsevier.com
dcsoto.bsky.social
Thrilled that our study on human gene duplications and brain evolution is out! It was a true labor of love, with special shout-outs to my co-first author @jmuribescr.bsky.social and my PhD mentor @mydennis.bsky.social. Huge thanks as well to @aidaandres.bsky.social for all the popgen wisdom!
mydennis.bsky.social
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
authors.elsevier.com
Reposted by Daniela C. Soto
mydennis.bsky.social
Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...
authors.elsevier.com
Reposted by Daniela C. Soto
mydennis.bsky.social
Check out our new preprint describing CiFi - a method that couples 3C and PacBio HiFi sequencing with low input requirements. We apply it to human GM12878 to better characterize chromatin across repetitive regions, as well as single insect samples (a mosquito and a Mediterranean fruit fly).
biorxiv-genomic.bsky.social
CiFi: Accurate long-read chromatin conformation capture with low-input requirements https://www.biorxiv.org/content/10.1101/2025.01.31.635566v1
Reposted by Daniela C. Soto
mydennis.bsky.social
The biggest congrats to former Dennis lab grad student Daniela Soto being named an HHMI Hanna Gray fellow!!! Soooooooo freaking proud and beyond-the-moon happy for her to have received this super well-deserved honor 🤩 www.hhmi.org/news/hhmi-na...
HHMI Names the 2024 Hanna Gray Fellows | HHMI
The cohort includes early career scientists working in research areas ranging from treatment-resistant cancers to how animals evolved to live on land. The HHMI Hanna H. Gray Fellows Program provides e...
www.hhmi.org
dcsoto.bsky.social
Thank you for the shout-out @mydennis.bsky.social! It was truly amazing to collaborate with Harrison Ostridge and @aidaandres.bsky.social in this study characterizing structural variation in the GYP locus.
mydennis.bsky.social
This GYPA SNP may have been selected for because it prevents the expression of a key receptor protein used by the malaria parasite to enter erythrocytes (though functional studies are still required). Shoutout to former grad student Daniela Soto for her outstanding work on this study!
Reposted by Daniela C. Soto
mydennis.bsky.social
Thrilled to have been a part of this study led by @aidaandres.bsky.social that finds evidence of genetic adaptation in chimpanzees to different habitats. Most notably signatures of positive selection in chimpanzees underlie resistance to malaria in humans (GYPA and HBB).