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Debnath Ghosal @debnathghosal.bsky.social · 9d

Great stuff @joshuamhardy.bsky.social ! Congratulations.

Josh Hardy @joshuamhardy.bsky.social · 10d

I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign

Reposted by Debnath Ghosal

Brett Collins @brettcollins.bsky.social · 18d

This is an amazing paper led by the Grinter lab on bacterial protein antibiotics called pyocins and the mechanism by which they inhibit the BAM outer membrane complex. @rhyswg.bsky.social, @knottrna.bsky.social, @debnathghosal.bsky.social, @doylemt1.bsky.social, @fabianmunder.bsky.social

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry

Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

www.biorxiv.org

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Debnath Ghosal @debnathghosal.bsky.social · 25d

Incredible!

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Debnath Ghosal @debnathghosal.bsky.social · 28d

We recently discovered a brand-new (and unique!) anti-phage defense system in bacteria. Check out this Pursuit article from @Melbourne University featuring our recent work. Terrific effort from our PhD student Somavally!

lnkd.in/geXUApmK

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Debnath Ghosal @debnathghosal.bsky.social · Sep 2

3 months, 3 thesis orations: a hat-trick moment for the lab!! 🎓🥳.
This time, Bindusmita in the spotlight! ✨ She delivered a fantastic thesis oration, packed with fascinating data and insights 🦠 ❄️ 🔬. It has been an absolute joy mentoring her. Huge congratulations @bindusmitapaul.bsky.social

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Reposted by Debnath Ghosal

Éric Hanssen @bigfrenchman.bsky.social · Aug 19

My longest ever running project, all the stars finally aligned after 13 years! Thank you to Eric Reynolds group for sharing the journey. #bio21-institute, #university-of-melbourne. @sepidehv.bsky.social @craigmorton.bsky.social @debnathghosal.bsky.social

www.nature.com/articles/s41...

Insights into type IX secretion from PorKN cogwheel structure bound to PorG and attachment complexes - Nature Communications

Type IX secretion system (T9SS) is required for protein export in the Bacteroidota. Here, the authors obtain structure of T9SS PorKN ring which resembles a cogwheel that may have a rotational movement...

www.nature.com

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Debnath Ghosal @debnathghosal.bsky.social · Aug 20

Super cool work! Congratulations!

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Debnath Ghosal @debnathghosal.bsky.social · Aug 20

Our collaborative work on the T9SS is just out in Nature Communications! Fantastic work led by Dhana Gorasia and Eric Hanssen. This paper reveals the structure of the T9SS outer membrane PorKN ring complex and mechanistic insights into protein secretion. www.nature.com/articles/s41...

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Debnath Ghosal @debnathghosal.bsky.social · Aug 7

Terrific news! Congratulations

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Debnath Ghosal @debnathghosal.bsky.social · Aug 3

Thanks Ariane :-)

Debnath Ghosal @debnathghosal.bsky.social · Aug 2

Indeed, thanks

Debnath Ghosal @debnathghosal.bsky.social · Aug 2

Wonderful collaboration with Sigal Ben-Yehuda lab! Our PhD student Somavally Dalvi, who just had her superb thesis oration drove the high-resolution imaging part of the project.
@unimelb, @FMDHS, @ccemmp-outreach.bsky.social

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Debnath Ghosal @debnathghosal.bsky.social · Aug 2

In this system, bacteria detect phage infection through a sensor protein (YjbH) and respond by severing the infected part of the cell via aberrant division. The rest of the cell survives and continues growing happily, essentially, bacterial autotomy!

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Debnath Ghosal @debnathghosal.bsky.social · Aug 2

Just as doctors may amputate an infected limb to save a patient’s life, or lizards drop their tails to escape predators, despite being single-celled organisms, bacteria can do a similar escape act. How cool is that?

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Debnath Ghosal @debnathghosal.bsky.social · Aug 2

📣 New paper alert! Just out in Cell Reports! pubmed.ncbi.nlm.nih.gov/40644298/
Thrilled to share that we have discovered a brand-new anti-phage defense system! Bacteria have evolved various defense strategies (CRISPR etc) to counter phage attacks. We found a new one - fascinating and dramatic
⚔️🦠❄️🔬

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Debnath Ghosal @debnathghosal.bsky.social · Aug 1

Of course! Let’s catch up

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Debnath Ghosal @debnathghosal.bsky.social · Aug 1

Very interesting work!

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Debnath Ghosal @debnathghosal.bsky.social · Aug 1

Amazing structure and insights! Congratulations.

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Reposted by Debnath Ghosal

Harvard Med Cell Biology @harvardcellbio.bsky.social · Jul 29

Thoughts from our own Tom Rapoport on the role of basic science in curing disease. magazine.hms.harvard.edu/articles/rev...

“Revolutionary Science Comes from Unexpected Angles”

magazine.hms.harvard.edu

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Debnath Ghosal @debnathghosal.bsky.social · Jul 29

Amazing insights!

Sorek Lab @soreklab.bsky.social · Jul 29

Of the 10 defense systems originally discovered in Doron et al 2018, Kiwa was one of the last to be studied - until now

Kiwa is a membrane-embedded complex activated in phage attachments sites to degrade phage DNA

A nice study by the Nobrega lab

Franklin Nobrega @fnobrega.bsky.social · Jul 28

Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.

www.cell.com/cell/fulltex...

Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.

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Reposted by Debnath Ghosal

Brendan Burns @brendanburns999.bsky.social · Jul 28

Great team of grad students and post docs and led together with an awesome group of PIs @debnathghosal.bsky.social @kmichie.bsky.social @iduggin.bsky.social. As something different here be a cool AI-generated artistic impression of our #Asgards hanging in their microbial mat 'ancient home'....⚔️

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Debnath Ghosal @debnathghosal.bsky.social · Jul 27

Thanks much Harry!

Debnath Ghosal @debnathghosal.bsky.social · Jul 27

Thanks Martin @pilhoferlab.bsky.social

Debnath Ghosal @debnathghosal.bsky.social · Jul 25

Massive Team effort! Thanks to all for bringing this together! @brendanburns999.bsky.social
@iduggin.bsky.social @kmichie.bsky.social
@snobsi.bsky.social , @juliameltzer.bsky.social, @xabivc.bsky.social, @tiltedscientist.bsky.social @bindusmitapaul.bsky.social @dcshepherd.bsky.social and others.

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Debnath Ghosal @debnathghosal.bsky.social · Jul 25

This offers the first glimpse into how complex eukaryotic cells may have evolved from archaeal ancestors — one of the biggest open questions in biology.
As ‪@brendanburns999.bsky.social‬ says: “Stromatolites may represent the ‘microbial village’ that helped raise a eukaryote.” Exciting times ahead!

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