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fnobrega.bsky.social
Franklin Nobrega
@fnobrega.bsky.social
820 followers 340 following 40 posts
Phage Biology, Bacterial defense systems, CRISPR-Cas, Microbial communities, Mucus interactions http://www.fnobregalab.org http://www.klebphacol.org http://www.phage-collection.org
www.fnobregalab.org
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fnobrega.bsky.social
Franklin Nobrega @fnobrega.bsky.social · Jul 28
Thrilled to see our Kiwa story out today! A membrane-associated supercomplex that senses infection and blocks replication and transcription.

www.cell.com/cell/fulltex...

Huge congratulations to Yi and Zhiying for bringing it home, to Thomas for starting us off, and to all the collaborators.
Kiwa is a membrane-embedded defense supercomplex activated at phage attachment sites
Zhang, Todeschini, and Wu et al. show that the bacterial defense system Kiwa senses phage attachment at the membrane and assembles a transmembrane complex that halts infection by blocking phage DNA re...
www.cell.com
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Reposted by Franklin Nobrega
filiphusnik.bsky.social
Filip Husnik @filiphusnik.bsky.social · 1d
OIST is seeking up to four tenure-track or tenured faculty in Ecology, Environmental Science, Earth Science, and Oceanography. Application deadline: Oct 15. Please share. Thx!
www.oist.jp/careers/facu...
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Reposted by Franklin Nobrega
frunzkelab.bsky.social
Julia Frunzke @frunzkelab.bsky.social · 9h
Please RT:
We have an opening for a junior group leader position in „Phage Biology & Biotechnology“.
www.fz-juelich.de/de/karriere/...

Interested candidates are encouraged to contact me via email for further details.

@spp2330.bsky.social; @mibinet.bsky.social
Junior Group Leader - Phage Biology & Biotechnology
As a leading research institution for microbial biotechnology the Institute of Bio- and Geosciences - Biotechnology (IBG-1, https://www.fz-juelich.de/de/ibg/ibg-1 ) at the Forschungszentrum Jülich foc...
www.fz-juelich.de
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Reposted by Franklin Nobrega
godi.bsky.social
Jelena Godrijan 🫧❾🌊🦋 @godi.bsky.social · 3d
⚠️New paper ➡️ isolating >600 freshwater microbes using dilution-to-extinction and low-nutrient, lake-mimicking media.

🤯Expands cultured diversity to ~70 % of detected genera and enables physiological studies of streamlined oligotrophs.

🔗 www.nature.com/articles/s41...
#protistsonsky
Bringing the uncultivated microbial majority of freshwater ecosystems into culture - Nature Communications
A large fraction of aquatic bacteria remains uncultured. Here, the authors cultivated 627 strains of abundant freshwater bacteria from 14 European lakes, thus generating a collection that includes many previously uncultured, oligotrophic bacteria that may serve as model organisms.
www.nature.com
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Reposted by Franklin Nobrega
erinrgreen.bsky.social
Erin Green @erinrgreen.bsky.social · 3d
Job alert ‼️ UChicago Micro is hiring! Open to tenured/tenure track faculty at all levels in any area of microbiology. Come join our amazing and growing department. apply.interfolio.com/174404
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Reposted by Franklin Nobrega
tunglejic.bsky.social
Tung Le @tunglejic.bsky.social · 4d
Independent research fellowships leading to tenured positions at the John Innes Centre.

Repost = nice. Thank you very much!!!
johninnescentre.bsky.social
John Innes Centre @johninnescentre.bsky.social · 5d
Shortlisted candidates will be invited to give a seminar at the Fellows Conference, which will be held on 10 March 2026.

Candidates who win Fellowships will be offered a Tenure Track Group Leader position from the outset, initially for 5 years.

Find out more: www.jic.ac.uk/training-car...
Independent Research Fellowships Leading to Tenured Faculty Positions | John Innes Centre
The John Innes Centre (JIC), is a world leading centre of excellence in plant and microbial sciences based on the Norwich Research Park, UK. We are inviting applications from outstanding researchers…
www.jic.ac.uk
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Reposted by Franklin Nobrega
vscooper.micropopbio.org
Vaughn Cooper @vscooper.micropopbio.org · 5d
DYK most P. aeruginosa carry filamentous phage(s) that don't need to kill the cell to reproduce?

We 👉🏻@nanamikubota.bsky.social show that these Pf phages can go ROGUE.

"Filamentous cheater phages drive bacterial and phage populations to lower fitness"

🔗 authors.elsevier.com/c/1lt5I3QW8S...
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Reposted by Franklin Nobrega
kristenobacter.bsky.social
Kristen DeAngelis 🏳️‍🌈🏳️‍⚧️🍉 @kristenobacter.bsky.social · 6d
UMass Amherst Microbiology is hiring a tenure-track virologist. Come work with me! 🦠🧪
careers.umass.edu/amherst/en-u...
Details - Assistant Professor - Virology | Human Resources | UMass Amherst
careers.umass.edu
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Reposted by Franklin Nobrega
assemblerag.bsky.social
Allison G @assemblerag.bsky.social · 7d
Most plasmids described in E. coli are small compared to the megaplasmids we identified here! Check out the preprint if you want to learn about these mysterious large elements and their potential functions 🧬. I’m very grateful to have had the opportunity to work on this in @banfieldlab.bsky.social
biorxiv-microbiol.bsky.social
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 7d
Megaplasmids associate with Escherichia coli and other Enterobacteriaceae https://www.biorxiv.org/content/10.1101/2025.09.30.679422v1
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Reposted by Franklin Nobrega
roszenil.bsky.social
Rosana Zenil-Ferguson @roszenil.bsky.social · 7d
The Department of Biology at the University of Kentucky is hiring a Microbiologist (broadly defined). Microbial eco-evo folks, this is your sign to come work with us. Not in the search committee, but happy to answer questions.
ukjobs.uky.edu/postings/600...
#microbiology #ecology
Assistant or Associate Professor in Microbiology
The Department of Biology in the College of Arts and Sciences at the University of Kentucky in Lexington, KY seeks to fill a tenure-eligible faculty position at the Assistant or Associate Professor le...
ukjobs.uky.edu
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Reposted by Franklin Nobrega
mfels.bsky.social
Max Fels @mfels.bsky.social · 6d
Are viruses capable of regulating protein synthesis in the nuanced way of cellular organisms? Kinda! I’m excited to share some of my postdoc work that leveraged giant DNA viruses to address this question.
Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life
In contrast to living organisms, viruses were long thought to lack protein synthesis machinery and instead depend on host factors to translate viral transcripts. Here, we discover that giant DNA virus...
www.biorxiv.org
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Reposted by Franklin Nobrega
benadler.bsky.social
Ben Adler @benadler.bsky.social · 6d
Today in @nature.com , we highlight how a cousin of CRISPR-Cas10, mCpol, establishes an evolutionary trap in anti-phage immune systems.

Check out @erinedoherty.bsky.social and my work from @doudna-lab.bsky.social lab here:
www.nature.com/articles/s41...
A miniature CRISPR–Cas10 enzyme confers immunity by inhibitory signalling - Nature
Panoptes, an anti-phage defence system against virus-mediated immune suppression, is revealed.
www.nature.com
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Reposted by Franklin Nobrega
contaminatedsci.bsky.social
Tami Lieberman @contaminatedsci.bsky.social · 8d
Precisely calling mutations across hundreds of bacterial isolates has been hard, requiring manual filtering and expertise.

Until now, using AccuSNV.

Herui Liao trained an ML model based on our previous meticulously called SNVs.
www.biorxiv.org/content/10.1...
High-accuracy SNV calling for bacterial isolates using deep learning with AccuSNV
Accurate detection of mutations within bacterial species is critical for fundamental studies of microbial evolution, reconstructing transmission events, and identifying antimicrobial resistance mutati...
www.biorxiv.org
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Reposted by Franklin Nobrega
cellarchlab.com
Ben Engel @cellarchlab.com · 8d
EXCITING NEWS!! We're searching for a new professor colleague at the Biozentrum🇨🇭. Ideal candidates are exploring novel biological questions with structure, biophysics, or high-resolution imaging. 🧪 🧶🧬 🔬

The call closes Nov 3. Please get in touch if you would like more information. Come join us! 👩‍🔬🤓
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Reposted by Franklin Nobrega
teppo-h.bsky.social
Teppo Hiltunen @teppo-h.bsky.social · 8d
Professor (full) or Associate Professor (tenure track) in Microbial Genetics of Health (U. Turku Finland). Competitive starting package included! Please share.

duunitori.fi/tyopaikat/ty...
Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto - Työpaikat - Duunitori
Avoin työpaikka: Professor or Associate professor (Tenure Track/Full) in Microbial Genetics of Health - Turun yliopisto, Turku. Duunitorilla lisäksi yli 30 000 muuta avointa työpaikkaa. Lue lisää nyt!
duunitori.fi
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Reposted by Franklin Nobrega
harmitmalik.bsky.social
Harmit Singh Malik @harmitmalik.bsky.social · 8d
When you swear to never work on phages, but phages still work on you… :)

Very cool story!!!
feldmanlab.bsky.social
Feldman Lab@WashU @feldmanlab.bsky.social · 8d
I said I will never work on phages, but having @micheleleroux.bsky.social next door made me change my mind. Here is Alexis's new paper showing how different phages deal with the capsular barrier to infect Acinetobacter! A great collaboration between our labs!
journals.plos.org/plospathogen...
Acinetobacter phages use distinct strategies to breach the capsule barrier
Author summary Acinetobacter baumannii causes life-threatening and often antibiotic-resistant infections thereby posing a global threat. Accordingly, there is an urgent need for alternative treatments...
journals.plos.org
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Reposted by Franklin Nobrega
geiselbiofilm.bsky.social
George O'Toole (he/him/his) @geiselbiofilm.bsky.social · 8d
Please share - an Assist Prof position in microbiology

employmentopportunities.umb.edu/mob/cw/en-us...

@asm.org
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Reposted by Franklin Nobrega
lucas.farnunglab.com
Lucas Farnung @lucas.farnunglab.com · 9d
New week, new tool: Find our Protein Domain Designer tool to generate publication-ready protein domain diagrams here: domaindesigner.farnunglab.com
Protein Domain Designer tool for the generation of publication-ready protein domain diagrams
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Reposted by Franklin Nobrega
lloeff.bsky.social
Luuk Loeff @lloeff.bsky.social · 9d
Hiring! 🧬🔬

Ever wondered how bacteria fight off viruses? We’re looking for a PhD student to dive into the molecular basis of newly discovered microbial immune systems, an area of biology where much remains to be uncovered.

RT/share to help us find our next team member!
www.lumc.nl/en/about-lum...
PhD-positie Bacteriële Verdedigingssystemen tegen Virussen | LUMC
Wij zoeken een getalenteerde en gemotiveerde PhD-kandidaat om het onderzoeksteam van Luuk Loeff te versterken. In dit project maak je gebruik van geavanceerde technologieën om te ontrafelen hoe bacter...
www.lumc.nl
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Reposted by Franklin Nobrega
raufs.bsky.social
Rauf Salamzade @raufs.bsky.social · 9d
And for those interested in creating figures - you can also feed zol results into cgcg to create network-graph visuals:
bsky.app/profile/rauf...
raufs.bsky.social
Rauf Salamzade @raufs.bsky.social · Dec 6
Check out this 1 min video on using zol + cgcg for scalable visualization of evo info across 1000s of homologous gene cluster instances (e.g. BGCs, phages, plasmids, defense islands, etc.) as network graphs.

Github: github.com/Kalan-Lab/zol
Docs: github.com/Kalan-Lab/zo...

#secmet #phage #genomics
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Reposted by Franklin Nobrega
rrwick.bsky.social
Ryan Wick @rrwick.bsky.social · 9d
Happy to share that the paper describing Autocycler is now 100% up:
doi.org/10.1093/bioi...
(1/3)
Autocycler: long-read consensus assembly for bacterial genomes
AbstractMotivation. Long-read sequencing enables complete bacterial genome assemblies, but individual assemblers are imperfect and often produce sequence-l
doi.org
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Reposted by Franklin Nobrega
joshuamhardy.bsky.social
Josh Hardy @joshuamhardy.bsky.social · 9d
I am thrilled to release ProteinDJ: a high-performance and modular protein design pipeline. Our open-source workflow incorporates #RFdiffusion, #ProteinMPNN, #FAMPNN, #AlphaFold2 and #Boltz-2. It is a fast, free, and fun way to design proteins (1/5)
doi.org/10.1101/2025.09.24.678028 #proteindesign
ProteinDJ logo
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Reposted by Franklin Nobrega
zaminiqbal.bsky.social
Zamin Iqbal @zaminiqbal.bsky.social · 12d
Delighted to see our paper studying the evolution of plasmids over the last 100 years, now out! Years of work by Adrian Cazares, also Nick Thomson @sangerinstitute.bsky.social - this version much improved over the preprint. Final version should be open access, apols.
Thread 1/n
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Reposted by Franklin Nobrega
jbdsf.bsky.social
Joe Bondy-Denomy @jbdsf.bsky.social · 12d
Our Department of Microbiology & Immunology at UCSF is running a faculty search this year for a new Assistant Professor! Please see the ad below for details. Searching for a great colleague, mentor, and scientist!
aprecruit.ucsf.edu/JPF05807
Microbiology and Immunology – Faculty Position (Ladder Rank) – Assistant Professor
University of California, San Francisco is hiring. Apply now!
aprecruit.ucsf.edu
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Reposted by Franklin Nobrega
kranzuschlab.bsky.social
Kranzusch Lab @kranzuschlab.bsky.social · 12d
You’ve heard of ubiquitination, meet deazaguanylation: Doug Wassarman in our lab discovered phage defense pathways have co-opted Q nucleobase biosynthetic enzymes to catalyze a new form of protein conjugation chemistry @science.org

www.science.org/doi/10.1126/...
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Reposted by Franklin Nobrega
craigmaclean.bsky.social
Craig MacLean @craigmaclean.bsky.social · 13d
New ERC funded computational postdoc position in my lab! We are looking for someone who will study the genomics of bacterial evolution using samples from experimental evolution and clinical trials. Lots of opportunities for interesting and fun collaboration!
my.corehr.com/pls/uoxrecru...
Job Details
my.corehr.com
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