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Feldman Lab@WashU @feldmanlab.bsky.social · 12h

Congratulations Evan, or I should say Dr. Pardue now!

Feldman Lab@WashU @feldmanlab.bsky.social · 7d

Acinetobacter exhibits cyrcadian rhythms! These bugs can predict the light cycles and adjust the expression of genes accordingy. Amazing collaboration with Alejandra Mussi's team from Rosario, Argentina, my city!!
rdcu.be/eIQzL

The critical human pathogen Acinetobacter baumannii exhibits light-regulated circadian rhythms

Communications Biology - Gene expression studies in the critical pathogen Acinetobacter baumannii identified the existence of daily rhythms displaying a robust response to light, as well as...

rdcu.be

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Feldman Lab@WashU @feldmanlab.bsky.social · 8d

Thank you! :)

Feldman Lab@WashU @feldmanlab.bsky.social · 8d

I said I will never work on phages, but having @micheleleroux.bsky.social next door made me change my mind. Here is Alexis's new paper showing how different phages deal with the capsular barrier to infect Acinetobacter! A great collaboration between our labs!
journals.plos.org/plospathogen...

Acinetobacter phages use distinct strategies to breach the capsule barrier

Author summary Acinetobacter baumannii causes life-threatening and often antibiotic-resistant infections thereby posing a global threat. Accordingly, there is an urgent need for alternative treatments...

journals.plos.org

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Feldman Lab@WashU @feldmanlab.bsky.social · 10d

Happy to share the last pre-print from my lab. Just in time for Evan’s thesis defense

www.biorxiv.org/content/10.1...

Dual Membrane-spanning Anti-Sigma 2 Controls OMV biogenesis and Colonization Fitness in Bacteroides thetaiotaomicron

Bacteroides spp. are Gram-negative, gut commensals that shape the enteric landscape by producing outer membrane vesicles (OMVs) that degrade dietary fibers and traffic immunomodulatory biomolecules. U...

www.biorxiv.org

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Reposted by Feldman Lab@WashU

Emmanuele Severi @emmseveri.bsky.social · 18d

www.biorxiv.org/content/10.1...

#microsky

A Protein Antibiotic Inhibits the BAM Complex to Kill Without Cell Entry

Many antibiotics are ineffective against Gram-negative pathogens such as Pseudomonas aeruginosa because they cannot penetrate the bacterial outer membrane. Here, we show that protein antibiotics calle...

www.biorxiv.org

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Feldman Lab@WashU @feldmanlab.bsky.social · Jul 8

The Feldman lab in the Acinetobacter conference in Niagara Falls

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Feldman Lab@WashU @feldmanlab.bsky.social · Jun 18

@benmicrobesmtg.bsky.social the organizers if the beneficial microbes conferences uninvited a scientist from the conference just based on their nationality. This act of racism should not be tolerated. I am happy I am not attending this conference. Shame on the organizers!

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Reposted by Feldman Lab@WashU

Michael Brockhurst @brockhurstlab.bsky.social · May 4

Highlights how the AMR crisis is also a cancer research issue

Redirecting just a tiny fraction of cancer research funding to AMR would be transformative

Antimicrobial resistance #AMR @antimicrobial.bsky.social · May 4

This large multi-center study shows cancer patients are infected with #AMR bacteria at 1.2 to 3 times higher rates due to frequent hospital visits and antibiotic use. This highlights the need for better antibiotic #stewardship and surveillance in these patients.

www.thelancet.com/journals/lan...

Incidence and prevalence of antimicrobial resistance in outpatients with cancer: a multicentre, retrospective, cohort study

AMR proportions and IRRs for most key pathogens were up to three-times higher in isolates from outpatients with cancer than those without cancer, highlighting the need for enhanced surveillance, infec...

www.thelancet.com

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Feldman Lab@WashU @feldmanlab.bsky.social · Apr 30

For those who have not seen Guy Cornelis in years, here you have the pic we took today. He looks the same, its quite remarkable!!

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Feldman Lab@WashU @feldmanlab.bsky.social · Apr 30

Today I gave a talk in Namur with a special guest: Guy Cornelis, the scientist that discovered T3SS and who was my postdoc advisor. He is retired now, came to my talk. I could not resist the temptation to take a selfie when I started my seminar! Academia has these great moments

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Feldman Lab@WashU @feldmanlab.bsky.social · Apr 29

www.biorxiv.org/content/10.1...

Intracellular Acinetobacter baumannii Acts as a Reservoir in Lung Infection via a 'Persist and Resist' Strategy

Although considered primarily extracellular, Acinetobacter baumannii can survive and replicate within macrophages in vitro. Intracellular bacteria are often protected from the host immune system and a...

www.biorxiv.org

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Feldman Lab@WashU @feldmanlab.bsky.social · Apr 29

Furthermore, using dual differential proteomics in collaboration with @nickescott.bsky.social we identified genes upregulated in both, the host and the bacteria. We show that genes involved in nutritional immunity, response stress and cell surface assembly are required for replication!

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Feldman Lab@WashU @feldmanlab.bsky.social · Apr 29

Yes! @manonjanet.bsky.social preprint is out! We show using BALF transfer that intracelular Acinetobacter baumannii can seed an infection in a susceptible mouse, suggesting that intracellular bacteria may be reservoir for recurrent infections
nam10.safelinks.protection.outlook.com?url=https%3A...

nam10.safelinks.protection.outlook.com

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Reposted by Feldman Lab@WashU

giseladivenanzio.bsky.social @giseladivenanzio.bsky.social · Apr 29

Deadline for the travel awards is tomorrow! Check the conference website for more information events.faseb.org/event/biolog...

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Feldman Lab@WashU @feldmanlab.bsky.social · Apr 11

The Feldman lab preparing the traditional empanadas for the department TGIF tomorrow.

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Reposted by Feldman Lab@WashU

Feldman Lab@WashU @feldmanlab.bsky.social · Nov 13

The Acinetobacter conference will be held in USA for the first time. The program is coming soon. events.faseb.org/event/biolog...

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Reposted by Feldman Lab@WashU

Gerry Wright @gdwantibiotics.bsky.social · Mar 26

The latest discovery from the lab and great colleagues at McMaster and U Illinois, Chicago. Lariocidin, a new lasso peptide antibiotic that inhibits the ribosome. rdcu.be/efdha

A broad-spectrum lasso peptide antibiotic targeting the bacterial ribosome

Nature - A new lasso peptide antibiotic exhibits broad-spectrum activity against Gram-negative and Gram-positive bacteria by interfering with bacterial protein synthesis, is unaffected by common...

rdcu.be

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Reposted by Feldman Lab@WashU

samuel mehr @mehr.nz · Mar 22

so far I'm seeing a lot of universities respond to grant terminations with

"oh I guess now we don't have that grant anymore"

instead of

"your assertion of a grant termination is executive overreach, see you in court"

So, universities: respectfully, what the fuck?

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Reposted by Feldman Lab@WashU

Maureen Barr @barrlab.bsky.social · Mar 20

In a science round table discussion yesterday, my NJ senator @kim.senate.gov suggested a strong argument for NIH and federal funding is global competitiveness. We US-based scientists should start weaving this into our narratives.

Don Moynihan @donmoyn.bsky.social · Mar 20

NIH spending more than pays for itself. It generates about $2.5 for every $1 spent. In terms of research productivity, NIH funding dwarfs the rest of the world. The only long-term potential rival is China. Politicizing the NIH's scientific processes will hand China a huge strategic advantage.

graph showing publication of NIH funded publications, relative to other funders. China is catching up.

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Feldman Lab@WashU @feldmanlab.bsky.social · Mar 19

Travel awards for trainees and early-stage investigators to attend the 2025 Acinetobacter conference are available. Deadline for applications is April 30. Please rt.

events.faseb.org/event/1b872d...

Biology of Acinetobacter XIV

events.faseb.org

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Feldman Lab@WashU @feldmanlab.bsky.social · Mar 11

Time to register to the 2025 Acinetobacter Conference in Niagara falls! Spaces are filling fast! We will soon announce some travel grants for graduate students/postdocs!

events.faseb.org/event/biolog...

Biology of Acinetobacter XIV

events.faseb.org

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Reposted by Feldman Lab@WashU

Mark Copelovitch @mcopelov.bsky.social · Mar 8

👇🎯 The public isn't going to understand this, unless the presidents of R1 universities around the country <loudly> & <collectively> get out into the public square & start explaining this & calling out the existential threat to the entire 🇺🇸 university system. The silence is deafening right now.

Tom Pepinsky @tompepinsky.com · Mar 8

The public really needs to understand this. Every university system in the world rests on public funding, there has never been an alternative model at any time in history.

We have universities for literally the same reason that we have roads and armies.

Dan de Kadt @dandekadt.bsky.social · Mar 8

I don't disagree that the US university business model was/is fragile, but surely not for this reason?

There is no society in the history of humanity that has successfully built a good university system without massive govt subsidies. US had already pushed the idea very far.

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Reposted by Feldman Lab@WashU

Oded Rechavi @odedrechavi.bsky.social · Mar 7

can you explain this 3 year gap in your resume?

yeah the paper was under review

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Feldman Lab@WashU @feldmanlab.bsky.social · Mar 5

Program is ready and registration is open! Acinetobacter aficionados join us in Niagara Falls for some days of great science. events.faseb.org/event/biolog...

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