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Elvira De Leonibus @deleonibuslab.bsky.social · Jun 26

Sometimes one is enough!

#neurons #tau

Elvira De Leonibus @deleonibuslab.bsky.social · May 19

🧠 Congrats Diletta Cavezza presenting at the:

@hippocampus spring meeting (lnkd.in/di4KNgYgin) in Verona!

"#Sex-dependent engagement of reuniens-hippocampal pathway during incidental encoding"

#Consiglio Nazionale delle Ricerche - IBBC

#Mnesys

Tigem
#Fondazione Telethon

Great meeting

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Elvira De Leonibus @deleonibuslab.bsky.social · Apr 18

Great!

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Apr 18

Targeted gene transfer into developmentally defined cell populations of the primate brain https://www.biorxiv.org/content/10.1101/2025.04.11.648413v1

Elvira De Leonibus @deleonibuslab.bsky.social · Apr 3

⚖️ Takeaway?
The good and the bad of dopamine all depend on the dose — and the circuit engaged.

🧠 A special thank to Maria De Risi, brilliant, talented, and extraordinarily productive scientist and to Diletta Cavezza #Giulia Torromino, Anita Capalbo Xabier Bujanda Cundin

Elvira De Leonibus @deleonibuslab.bsky.social · Apr 3

🧪 Our #phosphoproteomic data reveal that low vs. high doses of D1 agonist trigger completely different signaling profiles.
It’s as if we were administering two entirely different drugs — astonishing!

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Elvira De Leonibus @deleonibuslab.bsky.social · Apr 3

🧬 #PKA has long been considered essential for hippocampus-dependent long-term memory, but deleterious for #WM.
We demonstrate that PKA activation in the striatum is beneficial for working memory capacity. This calls for targeted, region-specific PKA modulators — intelligent PKA agents.

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Elvira De Leonibus @deleonibuslab.bsky.social · Apr 3

🧠💡 Why does this matter?

✅ We confirm that low doses improve memory in a schizophrenia mouse model, using the same dose range previously applied by #PatriciaGoldman-Rakic in monkeys (unlike the much higher doses in recent rodent studies).

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Elvira De Leonibus @deleonibuslab.bsky.social · Apr 3

✔️ High-dose recruits PKA in the cortex — again, not novel — but:

Cortical PKA activation recruits parvalbumin interneurons in the #striatum, shutting down the striatum, thus impairing memory.
Thus: a fronto-striatal circuit mechanism for the dose-dependent effects of DA drugs on memory.

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Elvira De Leonibus @deleonibuslab.bsky.social · Apr 3

This inverted-U dose-response curve is well-known in the literature — nothing new here.

🔍 So, what’s new?

✔️ Low-dose D1 stimulation expands MC via #PKA activation in the striatum.
We show that striatal PKA activation is both necessary and sufficient to enhance memory capacity.

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Elvira De Leonibus @deleonibuslab.bsky.social · Apr 3

🧠💥 For #Dopamine (DA) & #Memory lovers!

📢 New paper!! we show that memory capacity (MC) in mice can be expanded from 6 to 8 objects using low doses of a D1 receptor agonist. Higher doses? Paradoxically, they reduce MC.

#Tigem
#Consiglio Nazionale delle Ricerche

lnkd.in/d9skfGeb

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Reposted by Elvira De Leonibus

Jascha Achterberg @achterbrain.bsky.social · Mar 23

Looking for an exciting fellowship in AI & Neuro, with competitive salary (~£100k)? We got a new position in the lab at Oxford, working with @somnirons.bsky.social and me! 🧪

Our project: encode.pillar.vc/projects/beh...

General info: encode.pillar.vc

#compneuro #neuroai #neuroscience #sciencejobs

ARIA Opportunity Space: Scalable Neural Interfaces

encode.pillar.vc

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Elvira De Leonibus @deleonibuslab.bsky.social · Feb 25

It took so much time to get here, we cannot give up!

Matt Sikora @mjsikora.bsky.social · Feb 25

Super disappointing but it shouldn't stop us as reviewers from hammering grants and manuscripts that don't consider sex as a biological variable. We don't (...shouldn't) need an NIH mandate to do good science.

(But come on seriously this is so frustrating)

Dr. Becca @docbecca.bsky.social · Feb 25

Great write up at @thetransmitter.bsky.social on the seeming erasure of SABV in the new era of NIH. Gotta say The Transmitter is killing it the last few weeks, first to report on the Federal Register block and now this. Leading the charge! 💪 www.thetransmitter.org/policy/exclu...

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Reposted by Elvira De Leonibus

Colette Delawalla @cdelawalla.bsky.social · Feb 13

Young researchers mobilize to protest Trump administration’s science policies www.statnews.com/2025/02/13/r... via @statnews.com

@jpflores.bsky.social @samschuelstein.bsky.social @emmalovesscience.bsky.social @leslie-bern.bsky.social @standupforscience.bsky.social

Young researchers mobilize to protest Trump administration’s science policies

Stunned by attacks on the scientific research system, early career scientists plan a D.C. demonstration and a national ‘Stand Up for Science’ event.

www.statnews.com

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Elvira De Leonibus @deleonibuslab.bsky.social · Feb 2

Grazie Francesco ❤️

Elvira De Leonibus @deleonibuslab.bsky.social · Feb 2

📢 💥 We are ecstatic to announce that another one of our studies on Sanfilippo disease has been published in #MolecularPsychiatry.
#Sanfilippo is a rare genetic lysosomal storage disorder (#LSD) that leads to #neurodegeneration and #dementia.

www.nature.com/articles/s41...

D1 dopamine receptor antagonists as a new therapeutic strategy to treat autistic-like behaviours in lysosomal storage disorders - Molecular Psychiatry

Molecular Psychiatry - D1 dopamine receptor antagonists as a new therapeutic strategy to treat autistic-like behaviours in lysosomal storage disorders

www.nature.com

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Elvira De Leonibus @deleonibuslab.bsky.social · Jan 23

Hard time for #science @scinews.bsky.social

www.science.org/content/arti...

Trump hits NIH with ‘devastating’ freezes on meetings, travel, communications, and hiring

Researchers facing

www.science.org

Elvira De Leonibus @deleonibuslab.bsky.social · Jan 21

Non c'è mai fine al peggio!

Union of Concerned Scientists @ucs.org · Jan 20

President Trump announced today that he would seek to remove the US from the #ParisAgreement. “Such a move is in clear defiance of scientific realities and shows an administration cruelly indifferent to the harsh climate change impacts that people in the US and around the world are experiencing.”

President Trump Ignores Science, Makes Disgraceful Decision to Withdraw US from Paris Agreement

President Trump announced today that he would seek to remove the United States from the Paris Agreement. Statement by Rachel Cleetus, policy director for the Climate and Energy Program at UCS.

www.ucsusa.org

Reposted by Elvira De Leonibus

Earl K. Miller @earlkmiller.bsky.social · Jan 21

Remembering Eleanor Maguire, ‘trailblazer’ of human memory
www.thetransmitter.org/memory/remem...
#neuroscience

Remembering Eleanor Maguire, ‘trailblazer’ of human memory

Maguire, mastermind of the famous London taxi-driver study, broadened the field and championed the importance of spatial representations in memory.

www.thetransmitter.org

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Elvira De Leonibus @deleonibuslab.bsky.social · Jan 15

Hi Camille, we use rat 226 017. You can send an email to [email protected] for details

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Elvira De Leonibus @deleonibuslab.bsky.social · Jan 15

Super! Congrats!

Elvira De Leonibus @deleonibuslab.bsky.social · Jan 14

Mhh we use it, without problems. What is the problem?

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Elvira De Leonibus @deleonibuslab.bsky.social · Jan 5

Relevant to this www.pnas.org/doi/10.1073/...

The costs of competition in distributing scarce research funds | PNAS

Research funding systems fundamentally influence how science operates. This paper aims to analyze the allocation of competitive research funding fr...

www.pnas.org

Elvira De Leonibus @deleonibuslab.bsky.social · Jan 5

Thank Bita @bita137.bsky.social for this post. It gives us an idea of how much scientists need training on mentoring and evaluation, to understand our limitations and biases.

Bita Moghaddam @bita137.bsky.social · Jan 3

What is worst advice you have ever received from an academic?

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Reposted by Elvira De Leonibus

Earl K. Miller @earlkmiller.bsky.social · Jan 2

Striatal stimulation enhances cognitive control and evidence processing in rodents and humans
www.science.org/doi/10.1126/...
#neuroscience

Striatal stimulation enhances cognitive control and evidence processing in rodents and humans

Developing an animal model of human brain stimulation therapy reveals that striatal DBS enhances the brain’s ability to process conflicting evidence.

www.science.org

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Reposted by Elvira De Leonibus

Liset M. de la Prida @lmprida.bsky.social · Dec 31

Exciting news from the lab! In collaboration with our #EU-Nanobrigth partners, we’ve developed and tested a new probe for vibrational fiber photometry, enabling minimally invasive Raman spectroscopy deep into the 🧠. www.nature.com/articles/s41... @naturemethods.bsky.social

Vibrational fiber photometry: label-free and reporter-free minimally invasive Raman spectroscopy deep in the mouse brain - Nature Methods

Vibrational fiber photometry enables Raman spectroscopy in the mouse brain with low impact, owing to the use of tapered fibers.

www.nature.com

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