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Reposted by The Cancer Dependency Map

Francisca Vazquez PhD @vazquezf.bsky.social · Feb 6

(1/3) Excited to share our latest work using
@depmap.org to uncover a new synthetic lethality in two distinct patient populations!

We found that SKI complex inactivation through two independent genomic alterations creates a dependency on PELO

#CancerResearch #SyntheticLethality #Genomics #DepMap

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature

Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...

nature.com

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Reposted by The Cancer Dependency Map

The Cancer Dependency Map @depmap.org · Feb 5

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬

Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO-HBS1L

Congratulations to the DepMap team! @vazquezf.bsky.social
#depmap #cancertarget #syntheticlethal

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature

Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...

www.nature.com

5 3

The Cancer Dependency Map @depmap.org · Feb 5

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬

Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO-HBS1L

Congratulations to the DepMap team! @vazquezf.bsky.social
#depmap #cancertarget #syntheticlethal

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature

Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...

www.nature.com

5 3

The Cancer Dependency Map @depmap.org · Feb 5

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬
Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO
#depmap #cancertarget #syntheticlethal

Broad Institute @broadinstitute.org · Feb 5

Scientists have discovered a genetic vulnerability — found in 5 percent of adult cancers — that could be a promising drug target.

@nature.com #Science #Cancer @vazquezf.bsky.social

Mutations in two gene pairs point to a promising drug target in 5 percent of adult cancers

Targeting the PELO gene could be a way to kill tumor cells in cancers with one of two common genetic mutations.

www.broadinstitute.org

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The Cancer Dependency Map @depmap.org · Jan 29

📣Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute)

Highly recommended!

Register here
grc.org/synthetic-le...

2025 Synthetic Lethality Approaches in Oncology Conference GRC

The 2025 Gordon Research Conference on Synthetic Lethality Approaches in Oncology will be held in Portland, Maine. Apply today to reserve your spot.

grc.org

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The Cancer Dependency Map @depmap.org · Dec 20

DepMap keeps growing—and so does the portal!

To help navigate the portal, new in 24Q4 we’ve launched a new resource page 🚀! Check it out and share your feedback.

Depmap Resources | Depmap Portal

depmap.org

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The Cancer Dependency Map @depmap.org · Dec 18

We’re kicking off the first DepMap post with a bang!
⭐ 35 CRISPR screens
⭐ NEW data from our Pediatric Dependencies Accelerator Program (learn more at PedDep.org)
⭐ First 281 WES -> WGS
⭐ New Resources page
📣 DepMap is now on dbGaP (phs003444.v1.p1)
Read our release notes for more info!

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