David L. Goldblatt, MD.
@dgoldblatt.bsky.social
pending Pulm and Critical Care fellow @ UAB 7/2026. HHMI med fellow alumnus. Interested in #PCCM, #allergy, #asthma, & type 2 mucosal inflammation of the 🫁
Reposted by David L. Goldblatt, MD.
Patients with respiratory failure BUT withOUT commercial insurance at rural hospitals:
- LESS likely to be transfered to major centers
- More likely to die
pubmed.ncbi.nlm.nih.gov/40857001/
Important work by Emily Harlan, Tom Valley, and colleagues @jamanetworkopen.com @eliowa.bsky.social
- LESS likely to be transfered to major centers
- More likely to die
pubmed.ncbi.nlm.nih.gov/40857001/
Important work by Emily Harlan, Tom Valley, and colleagues @jamanetworkopen.com @eliowa.bsky.social
August 27, 2025 at 2:55 PM
Patients with respiratory failure BUT withOUT commercial insurance at rural hospitals:
- LESS likely to be transfered to major centers
- More likely to die
pubmed.ncbi.nlm.nih.gov/40857001/
Important work by Emily Harlan, Tom Valley, and colleagues @jamanetworkopen.com @eliowa.bsky.social
- LESS likely to be transfered to major centers
- More likely to die
pubmed.ncbi.nlm.nih.gov/40857001/
Important work by Emily Harlan, Tom Valley, and colleagues @jamanetworkopen.com @eliowa.bsky.social
I think we need a new strategy for smoking prevention...
August 17, 2025 at 8:24 PM
I think we need a new strategy for smoking prevention...
Blunting inflammatory and immune responses is another reason why blind correction of acidotic pH with bicarbonate in a sick patient is a bad idea www.cell.com/cell/fulltex...
Regulation of inflammatory responses by pH-dependent transcriptional condensates
BRD4 functions as an intracellular pH sensor through a conserved histidine-rich intrinsically
disordered region. Inflammation-associated acidification triggers a pH-dependent switch
in transcriptional...
www.cell.com
July 18, 2025 at 6:05 AM
Blunting inflammatory and immune responses is another reason why blind correction of acidotic pH with bicarbonate in a sick patient is a bad idea www.cell.com/cell/fulltex...
The natural tendency to KNOW there's a glaring error even if you can't find it somewhere in your PCCM application 5 mins after certifying it....
July 15, 2025 at 10:38 PM
The natural tendency to KNOW there's a glaring error even if you can't find it somewhere in your PCCM application 5 mins after certifying it....
Madueke: £50m (fee) + £21m (£80k/wk x 5 years) = £71,000,000 (total cost)
Rodrygo: £90m (fee) + £50m (£190k/wk x 5 years) = £140,000,000 (total cost)
And this likely underestimates Rodrygo's cost as he may command £200k+/wk wages. #arsenal
Rodrygo: £90m (fee) + £50m (£190k/wk x 5 years) = £140,000,000 (total cost)
And this likely underestimates Rodrygo's cost as he may command £200k+/wk wages. #arsenal
July 10, 2025 at 11:51 PM
Madueke: £50m (fee) + £21m (£80k/wk x 5 years) = £71,000,000 (total cost)
Rodrygo: £90m (fee) + £50m (£190k/wk x 5 years) = £140,000,000 (total cost)
And this likely underestimates Rodrygo's cost as he may command £200k+/wk wages. #arsenal
Rodrygo: £90m (fee) + £50m (£190k/wk x 5 years) = £140,000,000 (total cost)
And this likely underestimates Rodrygo's cost as he may command £200k+/wk wages. #arsenal
Besides providing an essential protective barrier, airway epithelial cells directly sense pathogens and respond defensively. #medsky #pulmsky 🩺🫁https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2021.749077/full
Frontiers | Airway Epithelial Innate Immunity
Besides providing an essential protective barrier, airway epithelial cells directly sense pathogens and respond defensively. This is a frontline component of...
www.frontiersin.org
December 11, 2024 at 6:11 AM
I did not think it would be possible to succinctly explain why I am so excited about PCCM's attainable future. 🫁🩺#pulmsky #medsky
www.atsjournals.org/doi/full/10....
www.atsjournals.org/doi/full/10....
From ICU Syndromes to ICU Subphenotypes: Consensus Report and Recommendations for Developing Precision Medicine in the ICU | American Journal of Respiratory and Critical Care Medicine
www.atsjournals.org
December 7, 2024 at 8:59 PM
I did not think it would be possible to succinctly explain why I am so excited about PCCM's attainable future. 🫁🩺#pulmsky #medsky
www.atsjournals.org/doi/full/10....
www.atsjournals.org/doi/full/10....
I had been aware of the hypothesis that azithromycin (AZM) had an "anti-inflammatory" effect distinct from anti-microbial action. This is used to justify liberal empiric AZM in COPD exacerbations, which are probably more likely to be viral #pulmsky #medsky www.frontiersin.org/journals/imm...
Frontiers | Azithromycin targets the CD27 pathway to modulate CD27hi T-lymphocyte expansion and type-1 effector phenotype
Macrolide antibiotic azithromycin is widely used in clinical practice to treat respiratory tract infections and inflammatory diseases. However, its mechanism...
www.frontiersin.org
December 5, 2024 at 9:22 PM
I had been aware of the hypothesis that azithromycin (AZM) had an "anti-inflammatory" effect distinct from anti-microbial action. This is used to justify liberal empiric AZM in COPD exacerbations, which are probably more likely to be viral #pulmsky #medsky www.frontiersin.org/journals/imm...
Is this bad? 🩺
October 11, 2024 at 10:47 AM
Is this bad? 🩺
In Speech, Biden Describes Surge of Antisemitism in U.S. www.nytimes.com/live/2024/05...
May 7, 2024 at 6:28 PM
In Speech, Biden Describes Surge of Antisemitism in U.S. www.nytimes.com/live/2024/05...
No more paxlovid for vax'd 🩺
Nirmatrelvir for Vaccinated or Unvaccinated Adult Outpatients with Covid-19 | NEJM
Nirmatrelvir in combination with ritonavir is an antiviral treatment for mild-to-moderate
coronavirus disease 2019 (Covid-19). The efficacy of this treatment in patients who
are at standard risk fo...
www.nejm.org
April 4, 2024 at 1:14 AM
No more paxlovid for vax'd 🩺
Cant wait for people who didnt actually read the study tell me why they need to stop their statin 🩺
Effects of statin therapy on diagnoses of new-onset diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis
Statins cause a moderate dose-dependent increase in new diagnoses of diabetes that
is consistent with a small upwards shift in glycaemia, with the majority of new diagnoses
of diabetes occurring in pe...
www.thelancet.com
March 31, 2024 at 2:02 AM
Cant wait for people who didnt actually read the study tell me why they need to stop their statin 🩺
We need more Med skytorials on here 🩺
March 28, 2024 at 7:48 PM
We need more Med skytorials on here 🩺
I did an organ harvest today and offered up my prefrontal cortex and they just laughed at me 🩺
January 23, 2024 at 1:51 AM
I did an organ harvest today and offered up my prefrontal cortex and they just laughed at me 🩺
Many years removed, still the only real achievement I've ever considered worth sharing 🩺🧪💊🔬🫁
Airway Epithelial Innate Immunity
Besides providing an essential protective barrier, airway epithelial cells directly sense pathogens and respond defensively. This is a frontline component of the innate immune system with specificity ...
www.frontiersin.org
December 30, 2023 at 12:11 AM
Many years removed, still the only real achievement I've ever considered worth sharing 🩺🧪💊🔬🫁
Reposted by David L. Goldblatt, MD.
Favorite scientific paper(s) of the last year?
I am a fan of these 2 papers supporting the concept that allergic immunity evolved as a host protective system to detect and avoid noxious environmental stimuli. #ImmunoSky 🧪🦠🩺
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I am a fan of these 2 papers supporting the concept that allergic immunity evolved as a host protective system to detect and avoid noxious environmental stimuli. #ImmunoSky 🧪🦠🩺
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Immune sensing of food allergens promotes avoidance behaviour - Nature
A study using mouse models of food allergy shows that allergic sensitization drives antigen-specific avoidance behaviour mediated by immunoglobulin E antibodies and mast cells.
www.nature.com
December 26, 2023 at 4:01 PM
Favorite scientific paper(s) of the last year?
I am a fan of these 2 papers supporting the concept that allergic immunity evolved as a host protective system to detect and avoid noxious environmental stimuli. #ImmunoSky 🧪🦠🩺
www.nature.com/articles/s41...
www.nature.com/articles/s41...
I am a fan of these 2 papers supporting the concept that allergic immunity evolved as a host protective system to detect and avoid noxious environmental stimuli. #ImmunoSky 🧪🦠🩺
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 23, 2023 at 7:25 PM
So, #PCCM feels the least fulfilled and the most burnt out? Does this surprise anyone else? 🩺
Article on JAMA:
jamanetwork.com/journals/jam...
Article on JAMA:
jamanetwork.com/journals/jam...
December 19, 2023 at 3:45 AM
So, #PCCM feels the least fulfilled and the most burnt out? Does this surprise anyone else? 🩺
Article on JAMA:
jamanetwork.com/journals/jam...
Article on JAMA:
jamanetwork.com/journals/jam...
Finally received the bsky invite! Excited to join the discussion on 🩺 and 🧪.
December 17, 2023 at 8:31 PM
Finally received the bsky invite! Excited to join the discussion on 🩺 and 🧪.