The Nobel Prize winner in Medicine is investigating genetic changes that could have given our species a competitive advantage, and the possibility of extracting the genome of the Flores hobbit

Accurate parametric inference on complex demographic models is a continuing challenge in population genetics. Ancestral recombination graphs (ARGs) provide richer information than simple population ge...

Snow leopards (Panthera uncia) serve as an umbrella species whose conservation benefits their high-elevation Asian habitat. Their numbers are belie...

Abstract. Despite transformative advances in genomic technologies, missing data remains a fundamental constraint that limits the full potential of genomic

Complex diseases driven by gene-environment interactions impose a heavy burden on human and animal health. Addressing these challenges requires innovative research. The emerging field of historical epigenomics offers a promising opportunity to link genotypes with phenotypes using preserved biological material. New methods such as historical chromatin profiling in museum specimens provide valuable insights into vertebrate genome regulation. Building on successful work with formalin-fixed paraffin-embedded (FFPE) samples, we expect growing interest in using historical specimens for biomedical, evolutionary, and ecological research. Applied to historical collections, these tools can provide critical baselines for understanding modern diseases, environmental stressors, and human adaptation.

200,000-year-old genes are oldest ever recovered from open-air site

The items to be returned, which include Java Man, were collected during the colonial era

The world's oldest DNA comes from a 2.4 million-year-old ecosystem in Greenland. Will scientists eventually sequence even older DNA?

The domestic goat likely first arrived to the island of Ireland as part of the introduction of agriculture approximately 5,900 years ago, and remains a part of the island's biocultural heritage. Howev...

Using genetic data from >1,200 South Africans, we examine admixture patterns from Cape Town to the historic colonial frontier’s northern edge, finding male-biased European ancestry and female-biased K...

Ancient DNA has revolutionized our understanding of human history and clarified many aspects of human evolution on a molecular level. In this article,…

Background Recent ancient DNA studies uncovering large-scale demographic events in Iberia have presented very limited data for Portugal, a country located at the westernmost edge of continental Eurasi...

Reflecting on our paper “The entities enabling scientific fraud at scale are large, resilient, and growing rapidly”

Screening shotgun-sequencing data from ancient humans covering 37,000 years of Eurasian history uncovers the widespread presence of ancient bacterial, viral and parasite DNA and zoonotic pathogens…

Ancient DNA extracted from the sediments of archaeological sites (sedaDNA) can provide fine-grained information about the composition of past ecosystems and human site use, even in the absence of skel...

Horses have lived in Iberia since the Ice Age. Using ancient genomes to study their history, Lira Garrido et al. reveal a local wild lineage lasting until Late Iron Age, and highlight the far-rea...

Abstract. Population genomic analyses rely on an accurate and unbiased characterization of the genetic composition of the studied population. For short-rea

Researchers from the University of Adelaide, New Zealand’s Manaaki Whenua-Landcare Research and University of Auckland have discovered that more than 80 per cent of parasites detected in kākāpō ...

Abstract. The Hongshan culture, situated at the crossroads of northern and northeast China, represented one of the earliest complex societies in Neolithic