drboulware.bsky.social
Dr. David Boulware, MD MPH
@drboulware.bsky.social
1.9K followers 730 following 180 posts
Professor of Medicine at U of MN; Practicing infectious disease doc; budding mycologist; interested in cryptococcal & TB meningitis. Ran some RCTs during COVID, but more excited to return to focus on RCTs on HIV-related meningitis & advanced HIV disease
Posts Media Videos Starter Packs
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · 2d
Twin Cities Marathon Day.

Brunch with neighbors on front lawn cheering on runners.
2
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · 5d
Excited to speak at UT Houston-Methodist on Friday on "Innovative Clinical Trial Designs in ID"

First time I have been back to Houston in 26 years. It's still hot... and even more buildings on medical campus.
1
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · 20d
The new Dr. Fungus app is now available on all iOS and Android devices. This app serves as a handy companion to the Dr. Fungus website, providing quick, easy access to information on fungal organisms, medical mycoses, and antifungal medications. We will be continuing to improve and refine the app.
1
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · 20d
Mycosis Study Group has released DrFungus app for phones as a reference companion for yeast and mold infections.

iPhone apps.apple.com/us/app/dr-fu...
Android play.google.com/store/apps/d...

App designed by Dr Matt Pullen. @msgerc.bsky.social
‎Dr. Fungus
‎The Dr. Fungus app serves as a companion to the official Dr. Fungus website, the Mycoses Study Group Education and Research Consortium resource for fungal disease education. This app provides up-to-d...
apps.apple.com
1 2 7
Reposted by Dr. David Boulware, MD MPH
scooper-id.bsky.social
S. Evan Cooper 🦠 @scooper-id.bsky.social · Sep 5
More Than 20 Medical Groups Call For RFK Jr. To Resign
#IDSky #MedSky

www.idsociety.org/news--public...
Joint statement calling for Secretary Kennedy resignation
www.idsociety.org
1 1 4
Reposted by Dr. David Boulware, MD MPH
docwinter.bsky.social
Dr. Susan Winters ☕️ @docwinter.bsky.social · Sep 3
Two studies, same signal👇
📊 COVID-OUT RCT: 41% ↓ long COVID with 14d metformin (1500 mg/day by Day 6).
📊 CID UK cohort (766k pts): 64% ↓ long COVID if metformin started within 90d.

Cheap, safe, generic drug. Replication across RCT + real world = 🔥

#MedSky
Effect of Metformin on the Risk of Post-coronavirus Disease 2019 Condition Among Individuals With Overweight or Obese: A Population-based Retrospective Cohort Study
Early metformin treatment in overweight or obese adults with recent coronavirus disease 2019 infection significantly reduces the risk of developing post–co
academic.oup.com
2 3 3
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Sep 4
Are childhood vaccination requirement to attend public school (with a parental opt out) equivalent to slavery? No.
1
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Sep 4
IDSA @idsainfo.bsky.social calls for the resignation of RFK Jr. as "Health" Secretary.
Are there other organizations which will call for this?

www.idsociety.org/news--public...
Joint statement calling for Secretary Kennedy resignation
www.idsociety.org
4 7
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Sep 2
Much more interesting and relevant would be the EPIC-SR results which showed no such benefits.

That would be more relevant data for today’s population in 2025 and beyond. @ofidjournal.bsky.social
1
Reposted by Dr. David Boulware, MD MPH
leanhealth.bsky.social
Dr. med. Hank Schiffers @leanhealth.bsky.social · Sep 2
#Metformin reduces risk on developing #PCC from 27,9% to 11.2% if started within 90 days of #SARS-COV-2 infection in #overweight/#obese patients in real-world settings (624 308 patients propensity-score)

Risk Difference At 1 y (%) -12,58%
Adjusted Hazard Ratio 0.36 academic.oup.com/cid/advance-...
Effect of Metformin on the Risk of Post-coronavirus Disease 2019 Condition Among Individuals With Overweight or Obese: A Population-based Retrospective Cohort Study
Early metformin treatment in overweight or obese adults with recent coronavirus disease 2019 infection significantly reduces the risk of developing post–co
academic.oup.com
4 11
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Sep 2
Why is OFID publishing a #covid study from 2021 reporting #paxlovid secondary trial results by Pfizer in high risk unvaccinated results - while burying the same results in the lower risk trial. @ofidjournal.bsky.social

Low risk results were presented at IDweek

academic.oup.com/ofid/article...
Patient-Reported Outcomes of Nirmatrelvir Treatment for High-Risk, Nonhospitalized Adults With Symptomatic COVID-19
In a phase 2/3 trial, high-risk adults with confirmed symptomatic COVID-19 receiving nirmatrelvir/ritonavir twice daily for 5 days reported global impressi
academic.oup.com
1 2
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 25
America First? Not When It Comes to Your Health. www.nytimes.com/2025/08/24/o...

Money saved by impoundment. Opportunities lost. Video explains such opportunities to advance medical research to improve Anetjcan’s health
Opinion | America First? Not When It Comes to Your Health.
www.nytimes.com
2
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 24
Trip #2 to Minnesota State Fair. En route. Food agenda mapped out. Efficient goals before music.
1
Reposted by Dr. David Boulware, MD MPH
cmicomms.bsky.social
CMI Communications @cmicomms.bsky.social · Aug 24
🎙️ Just published a new #Communicable episode: Communi...

Hosted by Angela Huttner @angelahuttner.bsky.social
Josh Nosanchuk @josh-nosanchuk.bsky.social

with invited guests:
Hatim Sati (@who.int)
Dimitrios Kontoyiannis (@mdanderson.bsky.social)

Listen here:

#IDSky #Clinmicro #MedSky
Communicable E34: WHO's Fungal Priority Pathogens List
Fungal infections and disease have long been overlooked in terms of...
share.transistor.fm
5 10
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 23
Day 1 review of the Minnesota State Fair food by Tony Cu. Very Funny.
www.youtube.com/watch?v=XNwv...
#MNStateFair
2025 Minnesota State Fair - Day 1
YouTube video by Tony Cu
www.youtube.com
1
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 23
Only 153,988 on Day 2 of 2025.

Some Tips and Tricks for the State Fair by Tony Cu.
www.youtube.com/watch?v=eQZB...
Tony Cu's tips and tricks for the Minnesota State Fair #minnesotastatefair #minnesotastatefair2025
YouTube video by Tony Cu
www.youtube.com
1
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 22
Day 2 of Minnesota State Fair - the Great Minnesota Get Together.
Largest state fair in daily attendance. Today feels like a low 160,000 person day.
1 4
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 15
We have a great multi-national team of clinical researchers, statisticians, lab scientists, microbiologists, immunologists, pharmacologist, neuroscience, health economics, and probably another category unnamed.

If you want to change the world & change your life, consider a Fogarty Fellowship.
2
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 15
If you are an ID fellow or completing your PhD, interested in global health, interestd in clinical/translational research and want to learn about how clinical trials are run -- come join our team working in Uganda on trials in HIV-related meningitis or on trials in advanced HIV disease.
1 2
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 15
Fogarty International Clinical Research Fellowship: Seeking Applications
1 month away from the deadline for the July 2026- June 2027 fellowship year.
Opportunities in Global Health Research Training.
US applicants can come from any US institution.
For more info see:
fogartyfellows.org
Global Health Fellows | Northern Pacific Global Health Research Fellows Training Consortium
fogartyfellows.org
1
Reposted by Dr. David Boulware, MD MPH
id-journal.bsky.social
id-journal.bsky.social @id-journal.bsky.social · Aug 14
VP shunts are key for CSF diversion in refractory coccidioidal meningitis. In a study of 124 patients, 17% had abdominal pseudocysts, often with shunt malfunction symptoms. 71% had active infection.##idsky
Trapped Below: Abdominal Pseudocysts Associated with Ventriculoperitoneal Shunts in Coccidioidal Meningitis
AbstractVentriculoperitoneal (VP) shunts are the mainstay for cerebrospinal fluid (CSF) diversion in patients with refractory coccidioidal meningitis (CM)-associated hydrocephalus. Abdominal pseudocysts (APCs), an uncommon but known complication of distal shunt catheters, have not been well described in CM. We conducted a retrospective study of 124 patients with CM who underwent VP shunt placement between 2010 and 2024. APCs occurred in 21 patients (17%), with most presenting with symptoms of shunt malfunction rather than abdominal complaints. This incidence is notably higher than previously reported in patients with hydrocephalus due to other etiologies. Evidence of active Coccidioides infection was present in 71% of patients. Imaging typically revealed fluid collections at the distal catheter tip, and most patients underwent surgical intervention targeting the distal shunt. Despite intervention, recurrent shunt failures occurred in a substantial proportion. These findings add to the limited literature on APCs in CM and may inform future research into their presentation, contributing factors, and management.
academic.oup.com
1 2 2
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 9
Overall AI summary of low dose flucytosine (5FC) trial for #crypto meningiitis.
doi.org/10.1093/cid/...
1
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 9
Probably the regular 100mg/kg higher dose for a shorter duration would be better utilization.
1
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 8
Shout out to @cidjournal.bsky.social for excellent timeline to being online. Time from last participant exiting the trial to publication was ~6 months.

As an IDSA member supporting @idsainfo.bsky.social society journals with good submissions instead of going to profit-driven elsievier journal.
1 3
drboulware.bsky.social
Dr. David Boulware, MD MPH @drboulware.bsky.social · Aug 8
While survival was similar (in this small sample size n=48 vs n=171 from Ambition trial recruited in Uganda), re-hosptializations trended towards being likely higher.
1 2