Interested in respiratory infections? who isn't! Then register for this fab conference with a fantastic line-up of speakers and sessions @sangerinstitute.bsky.social Abstract submission open until 17th Nov!! @eventswcs.bsky.social

coursesandconferences.wellcomeconnectingscience.org/event/air-20...

Irish skies

Please join us if you can for this year's Influenza Update Meeting, and please spread the news! It will be another fun opportunity to meet other influenza researchers, make connections and discuss our ongoing research.

Our study on pasteurising influenza viruses in milk is now out! It's a nice simple story: influenza viruses (including H5N1) are killed really effectively by pasteurisation, but in raw milk they stay infectious - obvious public health implications of both points... (1/2)
rdcu.be/d73te

Really proud to share our preprint describing early adaptation of H5N1 to US dairy cattle, and showing how these mutations enhance the ability of the virus to infect other mammals, such as pigs and humans.

With @influenzal.bsky.social @vidhid.bsky.social @drclairesmith.bsky.social and many more!

Shoutout to the incredible team - Max, Sam, Japhette and Amy- who drove this over the line 🧪👏 ! #TeamScience

🚨 New paper alert! We developed a simple cell assay to evaluate drug efficacy and synergy against emerging SARS-CoV-2 strains. Here we test both novel and repurposed antiviral drugs, identifying synergies that could enhance treatment effectiveness. Read more here: journals.asm.org/doi/10.1128/...

last 2 days to apply! : We have a fully funded #PhD #studentship available in my lab for Oct25 @UCLchildhealth. Project will research new treatments/targets for airway inflammation during viral infection using complex in vitro models. Deadline 13th Dec
Apply here: forms.office.com/pages/respon...

Can you add me please

Good luck!

Hopefully the paper will be coming soon, watch this space!

we showed that antivirals remdesivir & RSV604, both reduce RSV viral load, but RSV604 uniquely modulates neutrophil activation—lowering degranulation (MPO/NE) and preserving cell viability. Showing that this model could offer advantages for #RSVTherapeutics 💊

we found that RSV drives neutrophil migration across the epithelial barrier, altering activation markers (CD11b, MPO, NE). we also show how endothelial cells modulate cytokine responses (IL-6, IL-8, IP-10) and neutrophil localisation.

Sure! we developed a co-culture model of airway epithelial, endothelial and neutrophils cells to simulate the air-blood barrier and study viral clearance & inflammation during RSV infection #RSV #Immunology funded by #animalfreeresearchuk #AFRUK

I'll be speaking this morning @btsrespiratory.bsky.social in "A Winter's Tale" session about the model we have developed to study RSV infection in children which was funded by Animal Free Research UK. Come find out more in Moore/4th at 11:05 #BTSwinter2024.

Emma Johnson and Tereza Masonou for the BALR early career researcher awards! Congratulations to both and to the BTS and Asthma+Lung UK winners!

A big day of output for the Human Cell Atlas, a global collaborative project with 100 countries to understand our ~37 trillion cells
A Wikipedia of our cells, a "remarkable achievement"
nature.com/articles/d41...
nature.com/immersive/d4...

The preliminary sequence from the H5N1 human case in British Columbia has been posted and it is not good news. The virus potentially has a quasispecies at HA residue 226 (H3 numbering). This is bad news because we know that mutations at residue 226 can increase binding to human receptors. 1/

#USDA has confirmed 3 more #H5N1 #birdflu infected dairy herds in California, bringing the state's total to 294, nearly 27% of herds in the state. All those herds were recorded in the past 2.5 months.
The cumulative national total is 508 herds across 15 states. www.aphis.usda.gov/livestock-po...

Incredibly proud of our talented postdoc Tereza Masonou for her talk on how the neutrophil response to SARS-CoV-2 differs depending on the age of the infected nasal epithelial cells @options2024. If you're here come see our posters P153, P198, P139 & P461 later today!