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David A. Hill, MD, PhD

@drdavidhill.bsky.social

100 followers 93 following 57 posts

Physician-Scientist and Attending Physician at the University of Pennsylvania and Children's Hospital of Philadelphia studying how #diet and #metabolism influence #immune #health and #inflammatory #disease. Web: https://www.med.upenn.edu/hilllab/

www.med.upenn.edu

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David A. Hill, MD, PhD @drdavidhill.bsky.social · Aug 27

Our lab’s latest paper is out now in Science Translational Medicine!

We show how dietary saturated fats—especially stearic acid—prime immune cells in the lung to drive inflammation, with implications for obesity-associated asthma and beyond! #Asthma #Obesity #STM

www.science.org/doi/10.1126/...

Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β–mediated inflammation in mice and humans

Obesity-associated saturated long-chain fatty acids regulate lung macrophage phenotype and function at steady state and during lung inflammation.

www.science.org

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David A. Hill, MD, PhD @drdavidhill.bsky.social · 22h

Thanks for your comment, Elaine! Yes, the data suggest that eating more unsaturated LCFA and less saturated LCFA could help asthma, regardless of obesity state, in some folks. We need to perform a randomized controlled Trial to test this hypothesis in humans.

David A. Hill, MD, PhD @drdavidhill.bsky.social · 1d

The immunologic relationship between #IgE-mediated #food #allergy and #EoE has long been an unknown. I delve into this important topic in a new Perspective article out now in @aaaaiorg.bsky.social's Journal of Allergy and Clinical Immunology.

pubmed.ncbi.nlm.nih.gov/41016484/

David A. Hill, MD, PhD @drdavidhill.bsky.social · 7d

I don’t have many heroes. Jane Goodall was one of them. I’m thankful to have been able to witness the life of such an extraordinary primate.

David A. Hill, MD, PhD @drdavidhill.bsky.social · 14d

Excited to have our work featured in the NIH Research Matters weekly update of research advances!

www.nih.gov/news-events/...

Dietary fatty acids may lead to a severe form of asthma

Scientists found preliminary evidence that dietary changes could be a potential approach to prevent a severe form of asthma, called neutrophilic asthma.

www.nih.gov

David A. Hill, MD, PhD @drdavidhill.bsky.social · 16d

Congrats to CHOP A/I fellow Alexandra Navard-Keck and the rest of the team on this awesome and highly clinically-relevant paper!

pubmed.ncbi.nlm.nih.gov/40484346/

Clinical Significance of Egg Sensitization in Pediatric Food Protein-Induced Enterocolitis Syndrome to Hen's Egg - PubMed

Our data suggest that testing for allergic sensitization to egg may help stratify patients with FPIES at risk for future IgE-mediated symptoms. Future prospective studies should evaluate the optimal t...

pubmed.ncbi.nlm.nih.gov

David A. Hill, MD, PhD @drdavidhill.bsky.social · 20d

I’m genuinely honored and incredibly excited to have been chosen as one of ten inaugural Pennsylvania Commonwealth-Engaged Scholars! I’m really looking forward to engaging with policymakers, legislators, and community stakeholders across this great Commonwealth!

almanac.upenn.edu/articles/pen...

Penn Launches New Statewide Engagement Initiative

almanac.upenn.edu

David A. Hill, MD, PhD @drdavidhill.bsky.social · Sep 8

Check out this timely editorial from some of the leaders in the artificial intelligence in Allergy and Immunology field!

pubmed.ncbi.nlm.nih.gov/40914297/

Artificial Intelligence in the Detection and Management of Eosinophilic Gastrointestinal Diseases: Applications, Challenges, and Future Outlook - PubMed

Artificial Intelligence in the Detection and Management of Eosinophilic Gastrointestinal Diseases: Applications, Challenges, and Future Outlook

pubmed.ncbi.nlm.nih.gov

David A. Hill, MD, PhD @drdavidhill.bsky.social · Sep 4

Thanks @usnews.com!

www.usnews.com/news/health-...

www.usnews.com

David A. Hill, MD, PhD @drdavidhill.bsky.social · Sep 4

Thanks #TheScientist!

www.the-scientist.com/obesity-asso...

Obesity-Associated Asthma Has a Dietary Source

Saturated fatty acids directly activated innate immune cells in the lung, leading to inflammatory responses.

www.the-scientist.com

David A. Hill, MD, PhD @drdavidhill.bsky.social · Sep 4

Thanks @contemppeds.bsky.social!

www.contemporarypediatrics.com/view/dietary...

Dietary fats linked to neutrophilic asthma through lung inflammation pathways

Certain dietary fats trigger neutrophilic asthma by activating lung immune cells independent of obesity, study findings show.

www.contemporarypediatrics.com

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David A. Hill, MD, PhD @drdavidhill.bsky.social · Sep 4

Thanks @emjreviews.bsky.social!

www.emjreviews.com/respiratory/...

High-Fat Diets Tied to Lung Inflammation and Worse Asthma

Study shows diets high in saturated fatty acids drive lung inflammation and worsen airway disease, similarly to obesity-related asthma.

www.emjreviews.com

Reposted by David A. Hill, MD, PhD

Science Magazine @science.org · Aug 28

Dietary saturated fatty acids skew monocytes and macrophages in the lungs toward an inflammatory phenotype and exacerbate airway inflammation in mice, shows a study that decrypts the connection between diet and lung immune cell activation. #ScienceTranslationalMedicine https://scim.ag/3JzRozE

Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β–mediated inflammation in mice and humans

Obesity-associated saturated long-chain fatty acids regulate lung macrophage phenotype and function at steady state and during lung inflammation.

scim.ag

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Reposted by David A. Hill, MD, PhD

Nature Metabolism @natmetabolism.nature.com · Sep 1

#NatMetabPicks | In Science Translational Medicine led by @drdavidhill.bsky.social (‪@pennmedicine.bsky.social)

Dietary saturated fatty acids reprogram lung immune cells towards an inflammatory state, which exacerbates asthma in mice.

🧪

doi.org/10.1126/scit...

Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β–mediated inflammation in mice and humans

Obesity-associated saturated long-chain fatty acids regulate lung macrophage phenotype and function at steady state and during lung inflammation.

doi.org

4 9

David A. Hill, MD, PhD @drdavidhill.bsky.social · Aug 27

Dietary saturated fatty acids promote lung myeloid cell inflammasome activation and IL-1β–mediated inflammation in mice and humans

Obesity-associated saturated long-chain fatty acids regulate lung macrophage phenotype and function at steady state and during lung inflammation.

www.science.org

1 1

David A. Hill, MD, PhD @drdavidhill.bsky.social · Aug 26

More evidence of the #Mediterranean diet's health benefits!

What about effects on the #immune system (stay tuned!)?

www.acpjournals.org/doi/10.7326/...

Comparison of an Energy-Reduced Mediterranean Diet and Physical Activity Versus an Ad Libitum Mediterranean Diet in the Prevention of Type 2 Diabetes: A Secondary Analysis of a Randomized Controlled T...

Background: Limited research has been done to evaluate the combined effect of energy reduction, Mediterranean diet (MedDiet), and physical activity on type 2 diabetes incidence. Objective: To evaluate...

www.acpjournals.org

David A. Hill, MD, PhD @drdavidhill.bsky.social · Aug 25

Wishing all the Philly School District students a happy and healthy school year!

David A. Hill, MD, PhD @drdavidhill.bsky.social · Aug 4

Very happy to share that Hill Lab post-doc Olivia Harding, PhD has received an NIH F32 fellowship - Congrats Liv!

David A. Hill, MD, PhD @drdavidhill.bsky.social · Aug 4

New paper just accepted at Science Translational Medicine!

Turns out that saturated dietary fats prime lung macrophages for IL-1β–driven inflammation—even in the absence of obesity!

Follow here to know as soon as it drops online!

#Immunology #Asthma #Inflammation #TranslationalResearch

David A. Hill, MD, PhD @drdavidhill.bsky.social · Aug 4

Finally enjoying a break from the heat here in Philadelphia - Yes, its always sunny but no, its not typically in the 90s!

David A. Hill, MD, PhD @drdavidhill.bsky.social · Jul 30

Its paper submission day!

David A. Hill, MD, PhD @drdavidhill.bsky.social · Jul 7

Check out this cool new article on #CVID from Kate Sullivan and her group @chopresearch.bsky.social !

pubmed.ncbi.nlm.nih.gov/40058414/

A predictive model for identification of pediatric individuals with common variable immunodeficiency through electronic medical records - PubMed

In spite of a high frequency of infections in the comparator population, the clinical signature of pediatric CVID was sufficiently distinctive to enable early identification.

pubmed.ncbi.nlm.nih.gov

David A. Hill, MD, PhD @drdavidhill.bsky.social · Jun 22

Grateful to the #NIH, #FoodAllergyFund, and our donors for making this work possible.

David A. Hill, MD, PhD @drdavidhill.bsky.social · Jun 22

📉 Did early allergen introduction reduce #FoodAllergy rates?

Our multi-year, multi-state study of >100K kids says YES.

Peanut and overall IgE-FA diagnoses dropped after early introduction guidelines.

📰 Coming soon in Pediatrics (@ameracadpeds.bsky.social) #Pediatrics #Allergy

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David A. Hill, MD, PhD @drdavidhill.bsky.social · Jun 9

I’m very excited to share that Divyansi Pandey (Penn CAMB/CPM) will be joining the lab for her PhD! In addition, we have Crystal Wang (undergraduate from Dartmouth) and Emily Hughes (Penn VMD student) joining us for the summer! Lots of great science ahead in the Hill Lab!

David A. Hill, MD, PhD @drdavidhill.bsky.social · May 30

It’s an honor to have our #EoE #TCR work featured in this months AAAAI Impact publication! Big thanks to the #AAAAI for supporting this work!

impact.aaaai.org/aaaai-member...

AAAAI Member’s Research: First Molecular Identity of Food Allergen Presentation and Immune Recognition in EoE

impact.aaaai.org

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