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DMartin @drddom.bsky.social · 16d

Amazing news today for HD patients! I hope this keeps up.

HDBuzz @hdbuzzfeed.bsky.social · 16d

uniQure reports promising results from a key clinical study, showing that its experimental gene therapy, AMT-130, may slow the progress of Huntington's disease

en.hdbuzz.net/the-first-do...

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DMartin @drddom.bsky.social · 17d

Working on my NSERC renewal & being reminded about all the projects we had lined up that have been scooped. At $37k/yr there's only so much we can do. And it's not much. Canadian science is laughably underfunded.

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Reposted by DMartin

Mathieu Ferron @mathieuferron.bsky.social · 18d

A big study in JAMA last year in which 185 909 children were exposed to acetaminophen during pregnancy. Conclusion: Acetaminophen use during pregnancy was not associated with children's risk of autism, ADHD, or intellectual disability in sibling control analysis.

pubmed.ncbi.nlm.nih.gov/38592388/

Acetaminophen Use During Pregnancy and Children's Risk of Autism, ADHD, and Intellectual Disability - PubMed

Acetaminophen use during pregnancy was not associated with children's risk of autism, ADHD, or intellectual disability in sibling control analysis. This suggests that associations observed in other mo...

pubmed.ncbi.nlm.nih.gov

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Reposted by DMartin

HDBuzz @hdbuzzfeed.bsky.social · 21d

SKY-0515, an oral drug, safely lowers huntingtin in people with HD—and may also reduce PMS1, a DNA repair protein. This two-pronged approach could open new doors for HD treatment. A larger Phase 2/3 trial is now underway.

Full article: en.hdbuzz.net/sky-0515-low...

SKY-0515 Lowers Huntingtin In People With Huntington’s Disease In Trial Update – HDBuzz

en.hdbuzz.net

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Reposted by DMartin

The Atlantic @theatlantic.com · 22d

David Letterman on his career mocking presidents: “Beating up on these people, rightly or wrongly, accurately or perhaps inaccurately, in the name of comedy—not once were we squeezed by anyone from any governmental agency, let alone the dreaded FCC.”

Watch more: bit.ly/4n0Uv2p

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DMartin @drddom.bsky.social · 22d

So, maybe this is a good time for Canadian networks to rescue shows like @jimmykimmel.com & The Late Show?

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DMartin @drddom.bsky.social · 24d

I think I wrote, edited, & discarded several versions of the same skeet(?) this week.

I think the last version was.... this job is hard.

Some projects I was about to triage after years of work were suddenly revived this week & things feel a bit better.

Hope the tides change for you too!

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DMartin @drddom.bsky.social · 25d

The very talented @cailyncreative.bsky.social took inspiration from Ruby at the vet & created this masterpiece on our whiteboard in the lab. Pretty sure we can never use it again & I'm ok with that. Makes me smile every time I see it.

Thanks again Cailyn!

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Reposted by DMartin

Joao Pereira @jdpereira.bsky.social · 25d

Sometimes I think everything is going to be ok, and we’ll be able to secure grants to keep doing this cool stuff we’re doing.

Sometimes I don’t really know.

Sigh.

Tomorrow will be better.

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DMartin @drddom.bsky.social · 28d

Feels like the world is on fire lately. So enjoy this pic of Ruby at the vet's office just after getting her vaccines. She loves the vet. Feel like she'd make a great receptionist.

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Reposted by DMartin

HDBuzz @hdbuzzfeed.bsky.social · Sep 10

Pridopidine has been studied for decades as a possible treatment for Huntington’s disease. The PROOF-HD trial didn’t meet its primary goals, but its full results are now published—making valuable data available for the HD community.

en.hdbuzz.net/proof-in-the...

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DMartin @drddom.bsky.social · 29d

Meant to say, thanks for all your help!

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DMartin @drddom.bsky.social · 29d

Save the Date for the next @csmb-scbm.bsky.social meeting:
Membrane Proteins in Health & Diseases
April 8-12, 2026 in beautiful Banff!
Looks like there's something for everyone.
event.fourwaves.com/2026csmb/pages

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DMartin @drddom.bsky.social · Sep 9

Thanks! Feel pretty good about this version, but who knows. I'm still just hoping to get discussed. My bar is pretty low.

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DMartin @drddom.bsky.social · Sep 8

I have reached the stage of file saving where the grant is labled as final, final-maybe, final maybe maybe... pray for me.

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Reposted by DMartin

Brokoslaw Laschowski @drlaschowski.bsky.social · Sep 5

Come join us at University of Toronto. We're hiring a Professor of computational cognitive neuroscience.

#neuroAI #compneuro jobs.utoronto.ca/job/Toronto-...

Professor - Computational Cognitive Neuroscience

jobs.utoronto.ca

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Reposted by DMartin

Andrew Iwaniuk @evoneuro.bsky.social · Sep 4

For anyone on the neuroscience job market, our ads are up. We are looking for anyone working in systems neuroscience of animals to join us in southern Alberta 🇨🇦
#academicsky #neuroskyence #neuroethology #academicjobs #Canada
neurojobs.sfn.org/job/39049/as...

Assistant Professor (Neuroscience, Tenure Track) - Lethbridge (City), Alberta (CA) job with University of Lethbridge | 39049

Assistant Professor (tenure track) of the Department of Neuroscience at the University of Lethbridge, Alberta, Canada

neurojobs.sfn.org

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DMartin @drddom.bsky.social · Sep 4

Someone is continuing to take good care of me while I'm home sick. Just nestled into the crook of my leg. :)

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DMartin @drddom.bsky.social · Sep 4

The upside to being home sick is all the Ruby cuddles. At least I submitted my CIHR in time....

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DMartin @drddom.bsky.social · Sep 2

Highly recommend.

Katie Mack @astrokatie.com · Sep 2

I’m doing a public talk with @perimeterinstitute.ca in Waterloo!

www.eventbrite.ca/e/how-the-un...

(Tickets are free but you have to be quick — Eventbrite ticket reservations open at 9am Eastern Sep 2, which is in… 5 minutes)

How the Universe Ends - Katie Mack (CIGI)

The Big Bang started the universe 13.8B years ago - but how might it end? Here's what modern astrophysics says about its ultimate fate.

www.eventbrite.ca

DMartin @drddom.bsky.social · Aug 27

Me too! Looking forward to your talk.

DMartin @drddom.bsky.social · Aug 27

Ugh. Just got a grant rejection that I had very high hopes for. Sadly, I think it was the death knell for Huntington disease work in the lab...

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DMartin @drddom.bsky.social · Aug 26

One of the perks of running is you get to see all the sites of the cities you run in first thing in the morning.

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DMartin @drddom.bsky.social · Aug 25

We were asked Autophagy Reports to summarize our work on S-acylation of SQSTM1/p62 in autophagy & Huntington Disease.
@jesuisyasmeena.bsky.social

www.tandfonline.com/doi/full/10....

Sequestering sequestosome 1 via S-acylation in autophagy, Huntington disease, and beyond

Protein mislocalization and aggregation are hallmark features in neurodegeneration. As proteins mislocalize, proteostasis deficiency and protein aggregation typically follow. Autophagy is a crucial...

www.tandfonline.com

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DMartin @drddom.bsky.social · Aug 24

Congratulations!

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