I've definitely had some really good reviews. But I've had too many where it's clear they didn't read my grant. When only a handful get funded I kind of get it. Why bother doing a good job if you know it's not getting funded?

I think you'd scream if I sent you my comments...

The library we wanted to screen was literally in the budget. Not sure how we can have prelim data when we can't buy the library....

We completed a whole drug screen of FDA drugs. Found a great hit. Aim2a was to map the drug. Aim2b was to do a high throughput screen of Thousands of new drugs. Was told there's no prelim data for aim2b. Apparently doing a complete drug screen wasn't enough prelim data.

I did. Same grant jumped up. But dying the same slow death at a new panel.

Publishing an aim killed my grant. I focused on the aim reviewers were most interested & eventually published the work. Then you could hear the collective shrug 🤷‍♂️ when they lost interest.

Thanks! Appreciate it. Every time I debate whether it's worth resubmitting. At this point all I can do is say yes, that's what I'd like to do, but have no money for it.

We have funding (small amount) for genetic approaches. We're pursuing that. But it's sad when we found a new target for a drug that's already in clinical trials for ALS, but criticized because we don't know the mechanism....like that's the point.

And also, it typically ends up in the top grants for 2 reviewers and killed by 1 reviewer.

But then why say it's important work? I'd rather they just say we're not interested.

Thanks. I've become accustomed to it. Still need the day to process. Luckily it's a snow day & everything is closed.

Thanks. Hard to let go as this is for a rare disease & we've worked with Cure VCP Disease the whole time. We have more models than anyone, a novel target & new drugs. Yet we can't get it funded. Our genetic approaches are funded & have traction. Hopefully that's enough.

Thanks!

Pretty sure a tank of Argon or N2 is less $100 and lasts a very long time.

The worst day since yesterday
youtu.be/XluslIGClRA?...