Hendrik Schroeder
@drjhschroeder.bsky.social
Reposted by Hendrik Schroeder
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
October 6, 2025 at 9:34 AM
BREAKING: The Nobel Prize in Physiology or Medicine has been awarded jointly to Mary E. Brunkow, Fred Ramsdell, and Shimon Sakaguchi "for their discoveries concerning peripheral immune tolerance"
Stay tuned for more.
#NobelPrize
Stay tuned for more.
#NobelPrize
Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair: Cell Reports www.cell.com/cell-reports...
Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair
Can et al. show that circulating group 2 innate lymphoid cells (ILC2s) rapidly migrate
from the intestine to the lung after helminth infection. These early responders bolster
type-2 immunity and barri...
www.cell.com
September 18, 2025 at 10:31 AM
Rapid group-2 innate lymphoid cell mobilization from the intestine aids in early lung defense and repair: Cell Reports www.cell.com/cell-reports...
IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity: Cell www.cell.com/cell/fulltex...
IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity
IL-25 treatment induces persistent adaptation of the small intestine, which is maintained
by ILC2s with functional and epigenetic qualities of immune memory. Effector-memory
ILC2s arise in multiple ti...
www.cell.com
September 6, 2025 at 10:18 PM
IL-25-induced memory type 2 innate lymphoid cells enforce mucosal immunity: Cell www.cell.com/cell/fulltex...
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens: Cell www.cell.com/cell/fulltex...
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens
Deleting a regulatory element in the Rorc gene depletes RORγt+ dendritic cells from
the intestine in mice, leading to a reduction of regulatory T cells and impaired oral
tolerance to antigens. This wo...
www.cell.com
September 3, 2025 at 1:04 AM
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens: Cell www.cell.com/cell/fulltex...
Reposted by Hendrik Schroeder
Excited to share our study describing a role for a subset of Thetis cells, TC IV, in tolerance to food antigens. A team effort led by Vanja Cabric and Yollanda Parisotto
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
A wave of Thetis cells imparts tolerance to food antigens early in life
Within the intestine, peripherally-induced regulatory T (pTreg) cells play an essential role in suppressing inflammatory responses to food proteins. However, the identity of antigen-presenting cells (...
www.science.org
May 21, 2025 at 6:24 PM
Excited to share our study describing a role for a subset of Thetis cells, TC IV, in tolerance to food antigens. A team effort led by Vanja Cabric and Yollanda Parisotto
www.science.org/doi/10.1126/...
www.science.org/doi/10.1126/...
Expansion of Interleukin‐22‐Producing Type 3 Innate Lymphoid Cells in the Gut of Tristetraprolin‐Deficient Mice - Toeuf - 2025 - European Journal of Immunology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Expansion of Interleukin‐22‐Producing Type 3 Innate Lymphoid Cells in the Gut of Tristetraprolin‐Deficient Mice
TTP controls the mRNA stability of multiple inflammatory cytokines. Despite a multiorgan inflammatory phenotype, TTP-deficient mice are protected from experimental colitis, in part, through the expan....
onlinelibrary.wiley.com
May 23, 2025 at 8:53 AM
Expansion of Interleukin‐22‐Producing Type 3 Innate Lymphoid Cells in the Gut of Tristetraprolin‐Deficient Mice - Toeuf - 2025 - European Journal of Immunology - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity: Immunity www.cell.com/immunity/ful...
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity
CTLA-4 exists as membrane (mCTLA-4) and soluble (sCTLA-4) forms. Immunological roles
of sCTLA-4 are scarcely known. With mice deficient in either sCTLA-4 or mCTLA-4, Osaki
et al. show that sCTLA-4, wh...
www.cell.com
May 9, 2025 at 11:55 AM
Soluble CTLA-4 regulates immune homeostasis and promotes resolution of inflammation by suppressing type 1 but allowing type 2 immunity: Immunity www.cell.com/immunity/ful...
RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells | PNAS www.pnas.org/doi/10.1073/...
RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells | PNAS
Conventional dendritic cells (cDCs) are potent antigen-presenting cells (APCs) that
integrate signals from their environment allowing them to direc...
www.pnas.org
April 19, 2025 at 3:59 PM
RORγt-expressing dendritic cells are functionally versatile and evolutionarily conserved antigen-presenting cells | PNAS www.pnas.org/doi/10.1073/...
Reposted by Hendrik Schroeder
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens: Cell www.cell.com/cell/fulltex...
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens
Deleting a regulatory element in the Rorc gene depletes RORγt+ dendritic cells from
the intestine in mice, leading to a reduction of regulatory T cells and impaired oral
tolerance to antigens. This wo...
www.cell.com
April 12, 2025 at 7:36 AM
Rorγt-positive dendritic cells are required for the induction of peripheral regulatory T cells in response to oral antigens: Cell www.cell.com/cell/fulltex...
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis: Immunity www.cell.com/immunity/ful...
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis
Xiong et al. report that short-term, high-fat diet exposure rapidly alters the gut
microbial and immune environment, disrupting tissue homeostasis. IL-22 production
by group 3 innate lymphoid cells (I...
www.cell.com
April 15, 2025 at 3:38 PM
Acute exposure to high-fat diet impairs ILC3 functions and gut homeostasis: Immunity www.cell.com/immunity/ful...
The metabolic sensor LKB1 regulates ILC3 homeostasis and mitochondrial function: Cell Reports www.cell.com/cell-reports...
The metabolic sensor LKB1 regulates ILC3 homeostasis and mitochondrial function
ILC3s are essential for intestinal defense; however, how metabolism affects their
function has remained elusive. Fonseca-Pereira et al. show that LKB1 controls ILC3
function in a cell-intrinsic manner...
www.cell.com
April 3, 2025 at 11:11 AM
The metabolic sensor LKB1 regulates ILC3 homeostasis and mitochondrial function: Cell Reports www.cell.com/cell-reports...
Reposted by Hendrik Schroeder
Glial-immune interactions in barrier organs are reviewed by @franzeprogatzky.bsky.social and colleagues:
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
January 9, 2025 at 2:19 PM
Glial-immune interactions in barrier organs are reviewed by @franzeprogatzky.bsky.social and colleagues:
www.mucosalimmunology.org/article/S193...
www.mucosalimmunology.org/article/S193...
Reposted by Hendrik Schroeder
🎉 New Year, New Paper! We're excited to share our latest study led by @kyletreid.bsky.social, demonstrating human IL-10-producing ILC2s can be harnessed in cell therapies. 🧬✨ www.cell.com/cell-reports...
#Immunology #Transplantation #GVHD #RegenerativeMedicine #CellTherapy #ILC2
#Immunology #Transplantation #GVHD #RegenerativeMedicine #CellTherapy #ILC2
Cell therapy with human IL-10-producing ILC2s limits xenogeneic graft-versus-host disease by inhibiting pathogenic T cell responses
Reid et al. report that IL-10⁺ ILC2 cell therapy inhibits graft-versus-host disease (GVHD) in humanized mice, consistent with patient studies where IL-10⁺ ILC2s are associated with protection from GVHD. Human IL-10⁺ ILC2s express CD49d and CD86 and inhibit allogeneic T cell responses via an IL-4- and IL-10-dependent mechanism. These findings support harnessing IL-10⁺ ILC2s therapeutically.
www.cell.com
January 6, 2025 at 12:29 PM
🎉 New Year, New Paper! We're excited to share our latest study led by @kyletreid.bsky.social, demonstrating human IL-10-producing ILC2s can be harnessed in cell therapies. 🧬✨ www.cell.com/cell-reports...
#Immunology #Transplantation #GVHD #RegenerativeMedicine #CellTherapy #ILC2
#Immunology #Transplantation #GVHD #RegenerativeMedicine #CellTherapy #ILC2
Reposted by Hendrik Schroeder
ILC2 are a non-redundant source of IL-5 required for development and function of murine B1 cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
December 4, 2024 at 11:59 PM
ILC2 are a non-redundant source of IL-5 required for development and function of murine B1 cells
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Congratulations!
December 12, 2024 at 12:08 PM
Congratulations!