Xiao Huang
@drxiaohuang.bsky.social
Postdoc, Rudensky lab @mskcancercenter.bsky.social @ludwigcancer.bsky.social at Sloan Kettering | Postdoctoral Fellow, Cancer Research Institute | Former PhD trainee in the Murphy lab at WashU DBBS
Many thanks to funders @mskcancercenter.bsky.social, Cancer Research Institute, and @ludwigcancer.bsky.social at Sloan Kettering. 8/8
December 15, 2025 at 9:34 PM
Many thanks to funders @mskcancercenter.bsky.social, Cancer Research Institute, and @ludwigcancer.bsky.social at Sloan Kettering. 8/8
Special thanks to my mentors Sasha Rudensky and Christina Leslie for their guidance and support, and to Dan Feng and @snehamitra.bsky.social for their invaluable contributions to this work. 7/8
December 15, 2025 at 9:34 PM
Special thanks to my mentors Sasha Rudensky and Christina Leslie for their guidance and support, and to Dan Feng and @snehamitra.bsky.social for their invaluable contributions to this work. 7/8
Huge thanks to all our collaborators and coauthors who made this work possible. 6/8
December 15, 2025 at 9:34 PM
Huge thanks to all our collaborators and coauthors who made this work possible. 6/8
Importantly, this functional heterogeneity is conserved in human CRC and extends to other barrier-tissue cancers. 5/8
December 15, 2025 at 9:34 PM
Importantly, this functional heterogeneity is conserved in human CRC and extends to other barrier-tissue cancers. 5/8
These two Treg cell subsets also exhibit opposite enrichment patterns between adjacent normal colon tissues and tumors. 4/8
December 15, 2025 at 9:34 PM
These two Treg cell subsets also exhibit opposite enrichment patterns between adjacent normal colon tissues and tumors. 4/8
We found that IL-10⁺ Treg cells restrain tumor growth by suppressing IL-17 production from CD4⁺ T cells, whereas IL-10⁻ Treg cells promote tumor growth. 3/8
December 15, 2025 at 9:34 PM
We found that IL-10⁺ Treg cells restrain tumor growth by suppressing IL-17 production from CD4⁺ T cells, whereas IL-10⁻ Treg cells promote tumor growth. 3/8
To dissect Treg cell heterogeneity in MSS CRC, we employed the AKP organoid model, which closely recapitulates key features of human disease. 2/8
December 15, 2025 at 9:34 PM
To dissect Treg cell heterogeneity in MSS CRC, we employed the AKP organoid model, which closely recapitulates key features of human disease. 2/8