I need one too!...

I would say, depends: if you are only marginally expert in that field, decline, as other, more available and equally/more expert reviewers can take over. If you are a close expert, let the editor know of your time constraints and do it if they allow extra time. Holiday season is hell for reviews....

Finally, in the MPOA Gal+ Calcr+ hub of parenting, androgens shift the balance: increasing AR activity suppresses retrieval, while removing AR reduces aggression to pups and boosts care. Together: a hormone-to-cell type-to enhancer-to-behavior blueprint for state- and sex-specific parenting 🧠🧬 6/6

This maternal trigger doesn’t act alone—it recruits the core parenting hub (MPOA Gal+ Calcr+ neurons). Activating AvPe Brs3+ Vglut2+ neurons drives Fos expression in this hub, showing how a mother-tuned input can power a shared parenting circuit. 5/6

And we show this is how it works: oxytocin strongly excites these neurons in maternal brains, and deleting Oxtr or prolactin receptor in AvPe Vglut2+ neurons delays pup retrieval. Hormones aren’t just “on/off”—they change what the circuit responds to. 4/6

What makes these neurons “maternal”? Single-nucleus RNA-seq + ATAC-seq reveal a Prolactin → STAT5b program that remodels regulatory DNA and switches on oxytocin receptor (Oxtr) expression specifically in mothers. 3/6

First, we characterize a trigger node that is specific to mothers: excitatory AvPe neurons expressing Brs3 light up when moms first meet pups. Artificially activating them in virgin females boosts key maternal behaviors—like pushing the circuit over the threshold into care. 2/6

Amazing story and amazing cover too!

Congrats to @nbellono.bsky.social, Naomi and Wendy!.... such an amazing story 👏🎉🧪🧬

We’re excited to share the full dataset and analysis pipeline with the community. 6/6

Together, these data show that the brain, like the immune system, generates modular, pathogen-specific responses, not a single generic “sickness” program. 5/6

A 940-gene MERFISH atlas by @moffittlab.bsky.social revealed cell-type-specific immune responses in POA and PVN neurons and glia, including condition-specific interferon-stimulated genes, chemokines, and neuropeptides. 4/6

Whole-brain FOS imaging showed that each challenge produces a distinct neural activity pattern. Machine learning could classify sickness states using only these brain-wide signatures. 3/6