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From Black Box to Glass Box: AI Explainability in Stroke Treatment

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Reposted by DZNE research center

Stefan Hauser @stefanhauser.bsky.social · 6d

Join us for 𝗦𝘁𝗲𝗺 𝗖𝗲𝗹𝗹𝘀 𝗶𝗻 𝗡𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲, 𝟮𝟱𝘁𝗵-𝟮𝟳𝘁𝗵 𝗼𝗳 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆, 𝟮𝟬𝟮𝟲 in Tübingen, Germany.

Register here until 30th of November:
👉 stemcelltuebingen.com
Speaker slots and stipends available

Please repost and spread the news!

@dzne.science
@hih-tuebingen.bsky.social
@tueneurocampus.bsky.social

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Reposted by DZNE research center

CISPA Helmholtz Center for Information Security @cispa.de · 8d

In Liberate AI, an interdisciplinary research project with @dzne.science and Universitätsklinikum Bonn, CISPA researchers are helping to design a transparent, explainable AI model that will support doctors in the treatment of acute stroke. Learn more here cispa.de/en/liberate-ai

Liberate AI, an interdisciplinary research project, aims to develop an AI model capable of supporting doctors in the treatment of ischemic stroke. Serving as a digital assistance system, the AI model ...

cispa.de

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DZNE research center @dzne.science · 9d

DZNE is joining the Human Immunome Project (HIP) as a scientific partner and a member of the project’s European hub - together with @immunosens.bsky.social and the Germany-based "Swarm Learning Consortium".

👉 www.dzne.de/en/im-fokus/...

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DZNE research center @dzne.science · 11d

🧠 @thelancet.com series on #Alzheimer’s with contributions by DZNE scientists:
👉 www.thelancet.com/series-do/al...

The Lancet Series on Alzheimer’s disease

The initial successes of anti-amyloid β monoclonal antibodies offer new perspectives for improving the clinical trajectory of Alzheimer’s disease for the first time since its identification in 1906.

www.thelancet.com

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DZNE research center @dzne.science · Sep 4

🧠 Study in "Science Advances": Impaired spatial orientation found in older adults at risk for #Alzheimer’s disease

👉 @newsmedical.bsky.social: www.news-medical.net/news/2025090...

Impaired spatial orientation found in older adults at risk for Alzheimer’s disease

Individuals with an increased risk for dementia due to Alzheimer's disease can have impaired spatial orientation skills.

www.news-medical.net

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DZNE research center @dzne.science · Sep 4

Path integration impairments reveal early cognitive changes in Subjective Cognitive Decline
Vladislava Segen et al.
Science Advances (2025)
DOI: 10.1126/sciadv.adw6404 / URL: www.science.org/doi/10.1126/...

Path integration impairments reveal early cognitive changes in subjective cognitive decline

Virtual reality, modeling, and biomarkers reveal path integration deficits in presymptomatic Alzheimer’s versus normal aging.

www.science.org

What your spatial awareness reveals about your dementia risk | BBC Science Focus Magazine

DZNE research center @dzne.science · Sep 4

Study by DZNE scientists in "Science Advances" using VR technology shows that individuals with SCD - and thus increased risk for dementia due to 🧠 #Alzheimer’s - can have impaired spatial orientation skills.

👉 @sciencefocus.bsky.social: www.sciencefocus.com/news/spatial...

Difficulties with navigation and spatial awareness could reveal the earliest signs of Alzheimer’s disease, long before memory loss becomes apparent

www.sciencefocus.com

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Reposted by DZNE research center

The EMBO Journal @embojournal.org · Aug 25

Dragomir Milovanovic and coworkers @dzne.science dissect the structures and dynamics of actin polymerization upon biomolecular condensation of synaptic vesicles and phosphoprotein synapsin-1 during neurotransmission
www.embopress.org/doi/full/10....

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DZNE research center @dzne.science · Aug 15

📰 Press release: www.dzne.de/en/news/pres...

The Cerebral Cortex Ages Less than Thought

Evidence for neuroplasticity into advanced age speaks for the lifelong adaptability of the human brain.

Insights into Smelling Problems Associated with Alzheimer’s

DZNE research center @dzne.science · Aug 15

📰 Press release: www.dzne.de/en/news/pres...

Tests of the sense of smell could help identify people who are developing Alzheimer’s at an earlier stage.

500,000 US Dollars in Funding for Tau Research in Munich

DZNE research center @dzne.science · Aug 14

🏆 DZNE scientist Mikael Simons (Munich) has been selected as a 2025 #TauopathyChallengeWorkshop grantee by the #RainwaterCharitableFoundation:

👉 www.dzne.de/en/im-fokus/...

We report on: News, stories, interviews, personalia, prizes, awards, editorial tips, events

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DZNE research center @dzne.science · Aug 11

Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer’s disease.
Carolin Meyer, Theresa Niedermeier et al.
@natcomms.nature.com (2025).
DOI: 10.1038/s41467-025-62500-8

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DZNE research center @dzne.science · Aug 11

Layer-specific changes in sensory cortex across the lifespan in mice and humans.
Peng Liu, Juliane Doehler et. al.
@natneuro.nature.com (2025).
DOI: 10.1038/s41593-025-02013-1

DZNE research center @dzne.science · Aug 11

Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer’s disease.
Carolin Meyer, Theresa Niedermeier et al.
@natcomms.nature.com ‬(2025).
DOI: 10.1038/s41467-025-62500-8

DZNE research center @dzne.science · Aug 11

Layer-specific changes in sensory cortex across the lifespan in mice and humans.
Peng Liu, Juliane Doehler et al.
Nature Neuroscience (2025)
DOI: 10.1038/s41593-025-02013-1

Layer-specific changes in sensory cortex across the lifespan in mice and humans - Nature Neuroscience

DZNE research center @dzne.science · Aug 11

🧠 The human brain ages less than thought and in layers – at least in the area of the cortex responsible for the sense of touch. See study @natneuro.nature.com by @estherkuehn.bsky.social and colleagues at DZNE, @hih-tuebingen.bsky.social and @uni-magdeburg.de:

👉 www.nature.com/articles/s41...

The principal layer architecture of the sensory cortex is altered with aging. The authors show that overall thinning of the primary somatosensory cortex is driven by deep layer degeneration but that l...

Early Locus Coeruleus noradrenergic axon loss drives olfactory dysfunction in Alzheimer’s disease - Nature Communications

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DZNE research center @dzne.science · Aug 11

🧠 Research by DZNE scientists and colleagues gives insights into olfactory deficits in #Alzheimer's disease:

👉 www.nature.com/articles/s41...

Olfactory deficits occur early in Alzheimer’s disease (AD). Here, the authors identify that loss of locus coeruleus axons in the olfactory bulb underlies impaired olfaction in an AD mouse model and pr...

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DZNE research center @dzne.science · Jul 15

Proteomic aging signatures across mouse organs and life stages
Scifo, E.; Morsy, S.; Liu, T.; Xie, K. et al.
doi.org/10.1038/s443...

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment - Nature Neuroscience

Reposted by DZNE research center

The EMBO Journal @embojournal.org · Jul 15

Profiling the proteomes of key organs across the entire mouse lifespan reveals organ-specific as well as systemic alterations associated with aging
Dan Ehninger et al @dzne.science
www.embopress.org/doi/full/10....

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Reposted by DZNE research center

TübingenNeuroCampus @tueneurocampus.bsky.social · Jul 14

📢 Join us for the last talk of the semester in our Neurocolloquium, the "Hertie Network Lecture" on July 17 at 4.15pm: Susanne Wegmann (DZNE Berlin) @dzne.science will talk about "Cause & Consequences of neuronal Tau protein ‘activation’"
🙌 Host: @debkrov.bsky.social
👉 Zoom link tinyurl.com/32ku5jth

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DZNE research center @dzne.science · Jul 10

Charting γ-secretase substrates by explainable AI.
Breimann, S., Kamp, F., Basset, G. et al.
Nat Commun 16, 5428 (2025).
DOI: 10.1038/s41467-025-60638-z

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DZNE research center @dzne.science · Jul 10

Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment.
Ogunmowo, T.H., Hoffmann, C., Patel, C. et al.
Nat Neurosci (2025).
DOI: 10.1038/s41593-025-02002-4

DZNE research center @dzne.science · Jul 10

New work from the Milovanovic lab just out in Nature Neuroscience: Intersectin and endophilin condensates prime synaptic vesicles for release site replenishment

👉 www.nature.com/articles/s41...

Time-resolved electron microscopy reveals that intersectin-1 and endophilin A1 condensates hold replacement synaptic vesicles close to release sites. Without this, replacement vesicles are unavailable...

Charting γ-secretase substrates by explainable AI - Nature Communications

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DZNE research center @dzne.science · Jul 9

🔬Researchers from DZNE, @lmumuenchen.bsky.social, and
@tum.de have found that the enzyme “gamma-secretase” – implicated in #Alzheimer’s disease and cancer – selects its substrates according to a complex scheme of molecular features.

👉 @natcomms.nature.com: www.nature.com/articles/s41...

Comparative Physicochemical Profiling (CPP), an interpretable machine learning algorithm, identifies physicochemical signatures of γ-secretase substrates, capturing features hidden in sequences and en...