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Edelblum Lab

@edelblumlab.bsky.social

1.9K followers 440 following 150 posts

Assoc Professor and GI mucosal immunologist studying intestinal #gdTcells @IcahnMountSinai | #IBD researcher, patient and advocate | she/her www.edelblumlab.com #GIresearch starter packs: https://go.bsky.app/AHpSAzx & https://go.bsky.app/N1CFu1W

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

📚NEW #gdTcell PAPER ALERT! 'Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling' is now out in @mucosalimmunol.bsky.social! #gastrosky #GIsky #IBDsky Join us for a Bluetorial 🧵...

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling

Intraepithelial lymphocytes expressing the γδ T cell receptor (γδ IEL) provide continuous surveillance of the intestinal epithelium. We report that mi…

www.sciencedirect.com

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Reposted by Edelblum Lab

Itai Yanai @itaiyanai.bsky.social · 8d

Interested in learning how to be a good speaker and give effective talks? Season 2 of the NYC Postdoc Night Science Club begins October 15th. Join us NYC Postdocs for a 2hr workshop and maybe also a drink at a bar! Free registration (usually ~100 come): docs.google.com/forms/d/1dII...

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Edelblum Lab @edelblumlab.bsky.social · 6d

Join me & keynote speaker Dr. Florian Rieder at #CCCongress26, Jan. 22-24 in Vegas. @ibd-flomd.bsky.social does an outstanding job bridging #IBD basic science and clinical research, so this is sure to be a great talk Register by 10/21 & SAVE: 🔗 bit.ly/4m85s1N
#IBDsky #GIsky #Gastrosky

Home 2026

Join colleagues across the entire spectrum of clinical care and science at the premier conference on inflammatory bowel disease (IBD).

bit.ly

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Edelblum Lab @edelblumlab.bsky.social · 16d

First thing I’ll be reading post-vacay! #gdTcells + 🍄

Neil McCarthy @neilemccarthy.bsky.social · 17d

📚 NEW #gdT-cell PAPER from our team @QMUL.bsky.social! 🥳 'Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells' out now on @biorxiv-immuno
www.biorxiv.org/content/10.1... Here's my first attempt at a 'Bluetorial'... 🧵 1/10 #gastrosky #IBDsky

Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells

Gut symbionts condition mucosal immunity to resist infection by enteropathogens, but the specific microbes and mechanisms involved differ significantly between host species. In higher primates, bacter...

www.biorxiv.org

Edelblum Lab @edelblumlab.bsky.social · 17d

⭐️⭐️⭐️⭐️⭐️

Reposted by Edelblum Lab

bioRxiv Immunology @biorxiv-immuno.bsky.social · 18d

Bacterial suppression of intestinal fungi via activation of human gut γδ T-cells https://www.biorxiv.org/content/10.1101/2025.09.17.676560v1

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Edelblum Lab @edelblumlab.bsky.social · 27d

We’re welcoming Emma Andretta back to the magnificent world of #gdTcells! Before joining the Master’s program at Mount Sinai, she learned about the #bestimmunecellever with @boysonlab.bsky.social and then expanded to mucosal immunology at MSKCC in the Rudensky lab. Welcome Emma! 🤩

Edelblum Lab @edelblumlab.bsky.social · 27d

She’s got her white coat, so now @ananya-p.bsky.social is an official PhD student @sinaiimmuno.bsky.social ! That’s how that works, right? More #gdTcell magic to come! 😁

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Reposted by Edelblum Lab

NY-CURES @nycures.bsky.social · Sep 4

🚀 NY-CURES Launch — Championing State-Wide Investment in Science! 🚀

Our new coalition advocates for sustained public support of New York’s vibrant biomedical research ecosystem — creating cures, economic gains & strengthening communities.

Sign up. Stay informed. Join the movement: www.nycures.org/

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Edelblum Lab @edelblumlab.bsky.social · Aug 28

👀 We're on the lookout for a talented immunologist to join us for a postdoc at Mount Sinai! If you are a recent PhD graduate, love spectral flow and want to join our γδ T cell crew, apply below! Livable wage + subsidized housing + Central Park. Help us spread the word! #gdTcells #Immunosky #GISky

Post Doctoral Fellow-MSH-20093-003 in New York, NY | Mount Sinai Health Systems

Mount Sinai is hiring a Post Doctoral Fellow-MSH-20093-003 in New York, NY. Review all of the job details and apply today!

careers.mountsinai.org

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Reposted by Edelblum Lab

γδ T cell Forum @forum-gd.bsky.social · Aug 26

Don't miss the upcoming #Globalimmunotalk by Prof Adrian Hayday on August 27. I am sure it will be an absolute treat!

Talk Title: Lymphoid stress-surveillance, normality sensing, and integrated immunology.

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Edelblum Lab @edelblumlab.bsky.social · Aug 24

We’re all in the same boat taking on water. We’re all doing our best. I’ve found that honesty (without spiraling) and mental health convos help trainees right now. Enjoy the mtg — you should capitalize on the fun parts, b/c the hits keep coming and 99% of what’s happening is beyond your control.

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Edelblum Lab @edelblumlab.bsky.social · Aug 13

📣 Abstract submission for the 2026 Crohn's and Colitis Congress in Las Vegas is NOW OPEN! Deadline for submission is 9/24. We have an exciting Basic Science program covering #epigenetics, stem cells, #immunology, #microbiota & neural regulation of #pain with keynote talk by @ibd-flomd.bsky.social.

Home 2026

Join colleagues across the entire spectrum of clinical care and science at the premier conference on inflammatory bowel disease (IBD).

crohnscolitiscongress.org

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Reposted by Edelblum Lab

Mucosal Immunology @mucosalimmunol.bsky.social · Aug 13

Microbiota promote enhanced CD39 expression in γδ intraepithelial lymphocytes through the activation of TCR and IL-15 signaling in this work from @saraalonsomera.bsky.social @edelblumlab.bsky.social and colleagues: www.mucosalimmunology.org/article/S193...

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Edelblum Lab @edelblumlab.bsky.social · Aug 8

Thanks for spreading the love of #gdTcell biology!

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

Think that this is cool biology? We agree.
Love 20+ color flow?
Are you within 2-3 years of your PhD and are looking for a postdoc?
We're hiring @sinaiimmuno.bsky.social 😁 ⬇️

Post Doctoral Fellow-MSH-20093-003 in New York, NY | Mount Sinai Health Systems

Mount Sinai is hiring a Post Doctoral Fellow-MSH-20093-003 in New York, NY. Review all of the job details and apply today!

careers.mountsinai.org

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

We also have to thank @mahimaswamy.bsky.social for being a great #IEL collaborator and sharing tools & data with us! None of this would be possible without #NIH #NIDDK funding. As long as non-competitive renewals go through, we'll be digging more into the role of CD39 on IELs!

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

This study was @saraalonsomera.bsky.social's thesis work with assists from @andrewfong.bsky.social and Alyssa Laguerta. We are immensely grateful for the bioinformatics support from Ken Lau and @mikeverzi.bsky.social's labs and #SCENITH troubleshooting by @rafajarguello.bsky.social. 11/n

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

This is important since we published earlier this year in @sciimmunology.bsky.social that regulatory CD39+ γδ IELs are lost prior to the onset of ileal Crohn's disease. Knowing that TCR/IL-15 activation drives CD39 expression in γδ IELs may help restore tolerance to prevent ileal inflammation. 10/n

Dysregulation of γδ intraepithelial lymphocytes precedes Crohn’s disease–like ileitis

Multiple layers of γδ IEL dysregulation and loss of their immunosuppressive capacity occur before the onset of chronic ileitis.

www.science.org

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

Despite having more γδ IELs, γδHYP mice do not exhibit overt pathology. We find that this is because the mature CD39hi γδ IELs are more tightly regulated; they proliferate less, and are less likely to degranulate or produce less pro-inflammatory cytokine in response to stimulation. 9/n

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

It's been known for a long time that IL-15 promotes γδ IEL survival, and here is no exception as cell survival is increased in γδHYP IELs. As @mahimaswamy.bsky.social showed, IL-15 also promotes γδ IEL protein production & we find increased mitochondrial metabolism in CD39hi γδHYP IELs. 8/n

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

Further upstream, treatment with broad-spectrum antibiotics is sufficient to reduce CD122 and CD39 in γδHYP IELs, but it doesn't affect enhanced epithelial IL-15 production or the number of γδ IELs. This suggests that sustained γδHYP microbiota exposure is not req'd for CD39 upregulation. 7/n

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

TCR activation in the naive CD39lo γδ IELs is also critical for driving both CD122, and subsequently, CD39 expression as there is an additive effect on its expression when you culture CD39neg γδ IELs with both stimuli. TCRγδ internalization prevents the upregulation of both CD122 & CD39 in vivo. 6/n

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

CD39hi γδ IELs expressed the highest amount of CD122 and if we cultured CD39neg γδ IELs with IL-15RC, we could convert them to CD39pos or further upregulate its expression in already positive cells. Anti-CD122 blocked the upregulation of CD39 in γδHYP mice. 5/n

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

To determine why CD39 expression was increased, we performed CITE-seq and found that CD39 expression positively correlated with transition from a naive-like to tissue-adapted, mature γδ IEL state. Moreover, CD39hi γδ IELs expressed genes downstream of TCR and IL-15 signaling. 4/n

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Edelblum Lab @edelblumlab.bsky.social · Aug 7

Bulk transcriptomics revealed an increase in Entpd1, the gene encoding CD39, a known marker of regulatory γδ T cells. We found a clear shift in CD39 expression in γδHYP mice with more CD39hi γδ T cells in phenotypic mice. High CD39 expression was a feature of natural IELs, but we focused on γδs. 3/n

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