Correct text for post (4/6):
Sweeps bias towards a fast-moving bait during spontaneous pursuit, reorient when the animal loses and regains the target, and even reverse during backward locomotion to align with intended movement direction.
See 📹

Correct text for post (4/6):
Sweeps bias towards a fast-moving bait during spontaneous pursuit, reorient when the animal loses and regains the target, and even reverse during backward locomotion to align with intended movement direction.
See 📹

Thrilled to share w/ my eminent colleagues: @azvollan.bsky.social
@mschellenberger.bsky.social
@m-bmoser.bsky.social at @kavlintnu.bsky.social
Grateful for support by Norwegian Research Council; @erc.europa.eu by #KiloNeurons, & @kavlifoundation.org
Thanks to @rjgardner.bsky.social (6/6)

These changes occur instantly, without learning or trained goals. Rather than encoding routes to goals, theta sweeps act as a general, attention-like mechanism for continuously and selectively sampling of behaviourally relevant locations within an allocentric map. (5/6)

Whether the system can be flexibly redirected to prioritize specific locations has been unclear. Using large-scale #Neuropixels recordings in freely behaving rats, we find that both sweeps – and the internal direction signals driving them – are dynamically modulated moment by moment. (4/6)

Whether the system can be flexibly redirected to prioritize specific locations has been unclear. Using large-scale #Neuropixels recordings in freely behaving rats, we find that both sweeps – and the internal direction signals driving them – are dynamically modulated moment by moment. (3/6)

Theta sweeps are population sequences in #gridcells and #placecells that, once per theta cycle, radiate outward from the animal’s location. In baseline conditions, they alternate rigidly left-right around the head axis, generating broad, forward-oriented sampling of nearby #space. (2/6) 🧠🧹

Whether the system can be flexibly redirected to prioritize specific locations has been unclear. Using large-scale #Neuropixels recordings in freely behaving rats, we find that both sweeps – and the internal direction signals driving them – are dynamically modulated moment by moment. (4/6)

Whether the system can be flexibly redirected to prioritize specific locations has been unclear. Using large-scale #Neuropixels recordings in freely behaving rats, we find that both sweeps – and the internal direction signals driving them – are dynamically modulated moment by moment. (3/6)

Whether the system can be flexibly redirected to prioritize specific locations has been unclear. Using large-scale #Neuropixels recordings in freely behaving rats, we find that both sweeps – and the internal direction signals driving them – are dynamically modulated moment by moment. (3/6)

Theta sweeps are population sequences in #gridcells and #placecells that, once per theta cycle, radiate outward from the animal’s location. In baseline conditions, they alternate rigidly left-right around the head axis, generating broad, forward-oriented sampling of nearby #space. (2/6) 🧠🧹

Board chair Bjarne Foss, @m-bmoser.bsky.social @edvardmoser.bsky.social @torgrande.bsky.social HM King Harald V, Secretary General of @nasjonalforeningen.no Bo Gleditsch, Centre Directors @asgeirkf.bsky.social Gøril Rolfseng Grøntvedt and Minister of Research Sigrun Aasland @kd.regjeringen.no

5/5 Big thanks to the team and collaborators @clykken.bsky.social @beneuroscience.bsky.social @anagelhus.bsky.social @jocarpenter.bsky.social @matteoguardamagna.bsky.social @m-bmoser.bsky.social @kavlintnu.bsky.social
#Neuroscience #GridCells #PlaceCells #EpisodicMemory #Neuropixels #KiloNeurons

4/5 Conclusion: Independent phase changes across grid modules are sufficient to generate a vast array of distinct hippocampal representations.

Why this matters: Such combinatorial flexibility is a key requirement for forming episodic memories, offering a mechanism for high-capacity memory.

3/5 We discovered that when grid cell modules realigned differently between environments, hippocampal place cells remapped. Strikingly, the extent of this remapping was directly predicted by the disparity in phase changes across grid modules.

2/5 After two decades, our hypothesis for this space-to-memory transformation finally met a decisive test.
Led by our outstanding postdoc @clykken.bsky.social, we performed multi-area #Neuropixels recordings simultaneously from hippocampal place cells and multiple MEC grid cells modules in rats 🧠

Excellent work, and very interesting observations - congratulations!