banner
elevylab.bsky.social
Emmanuel Levy's lab
@elevylab.bsky.social
73 followers 55 following 6 posts
Structural & Systems Biology Lab @ University of Geneva | Exploring protein & proteome assemblies | Structured thoughts, intrinsically disordered views
Posts Media Videos Starter Packs
Reposted by Emmanuel Levy's lab
betowbin.bsky.social
Benjamin Towbin @betowbin.bsky.social · 9d
Tenure-track Assistant Professorship in #Quantitative #Cell #Biology at the ICB @unibern. Apply until 17 October. Combination of theory/computation and experiments particularly encouraged. Please repost!

www.nature.com/naturecareer...
1
Reposted by Emmanuel Levy's lab
centriolelab.bsky.social
Paul & Virginie - Centriole Lab @centriolelab.bsky.social · 23d
Be our new colleague! 🎉
The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor.

👉 More details here: lnkd.in/e8Z9eAm4
👉 Our department: mocel.unige.ch

Please feel free to share this opportunity with your network.
48 42
Reposted by Emmanuel Levy's lab
molsystbiol.org
Molecular Systems Biology @molsystbiol.org · 1d
10/2025 Issue ➡️ www.embopress.org/toc/17444292...
reduced genomes, adaptive mutations under stress, xenobiotics and gut microbiome, DMS analysis, TF effector metabolites
Cover: proteins can agglomerate with limited impact on cell by @elevylab.bsky.social
1 1 4
elevylab.bsky.social
Emmanuel Levy's lab @elevylab.bsky.social · 3d
@molsystbiol.org picked a neat cover for this month's issue 🙃 - Great work from Tal Levin, Hector Garcia-Seisdedos, many more colleagues (doi.org/10.1038/s443...) and great matching cover, too!
This month's cover highlights the article Mutation-induced filaments of folded proteins are inert and non-toxic in a cellular system by Emmanuel Levy, Hector Garcia-Seisdedos and colleagues. Yeast cells harboring mutation-induced filaments of folded proteins or “agglomerates”. The filaments appear large and disruptive, but surprisingly, Levin et al. reveal they are largely inert and non-toxic, unlike aggregates of misfolded proteins.
2 5
elevylab.bsky.social
Emmanuel Levy's lab @elevylab.bsky.social · 6d
Nice to see Tal's work featured in biotech news !

www.genengnews.com/topics/biopr...
Assay IDs Agglomerates for Intracellular Engineering
Protein agglomerates are reversible, so can serve as a regulatory mechanism for intracellular engineering.
www.genengnews.com
1
Reposted by Emmanuel Levy's lab
martinsteinegger.bsky.social
Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 18d
MMseqs2-GPU sets new standards in single query search speed, allows near instant search of big databases, scales to multiple GPUs and is fast beyond VRAM. It enables ColabFold MSA generation in seconds and sub-second Foldseek search against AFDB50. 1/n
📄 www.nature.com/articles/s41...
💿 mmseqs.com
GPU-accelerated homology search with MMseqs2 - Nature Methods
Graphics processing unit-accelerated MMseqs2 offers tremendous speedups for homology retrieval from metagenomic databases, query-centered multiple sequence alignment generation for structure predictio...
www.nature.com
4 64 170
elevylab.bsky.social
Emmanuel Levy's lab @elevylab.bsky.social · 22d
And cool to see our work featured in the journal! doi.org/10.1038/s443...
Thanks Rui Sun and Yu Liu ☺️
Protein aggregate or agglomerate: similar punctate structure with distinct biological profiles | Molecular Systems Biology
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
doi.org
elevylab.bsky.social
Emmanuel Levy's lab @elevylab.bsky.social · 22d
This work has been a long and exciting journey, taking my lab into yeast proteomics and protein functions. All possible thanks to the great work of Tal Levin, Hector Garcia-Seisdedos and @arseniylobov.bsky.social in particular. Also big thanks to our collaborator Ohad Medalia at ZurichU.
1
elevylab.bsky.social
Emmanuel Levy's lab @elevylab.bsky.social · 22d
The key experiments and findings of the paper are summarized in this graphical abstract:
1 1
elevylab.bsky.social
Emmanuel Levy's lab @elevylab.bsky.social · 22d
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
1 8 27
Reposted by Emmanuel Levy's lab
biology-unige.bsky.social
Biology-UNIGE @biology-unige.bsky.social · Aug 22
Congratulations @elevylab.bsky.social and collaborators for your latest publication in Cell 👏 and welcome to BlueSky 🦋@mocel.bsky.social‬ @sciencesunige.bsky.social
amunts.bsky.social
Alexey Amunts @amunts.bsky.social · Aug 22
Emmanuel Levy @elevylab.bsky.social has joined BlueSky 🌟 with a fantastic Cell paper with Shu-ou Shan, showing the interactome of the TOM complex and how cotranslational mito import prioritizes large globular domains. Beautiful science!
Give him a warm welcome 🎉
link: www.cell.com/cell/fulltex...
Principles of cotranslational mitochondrial protein import
Selective ribosome profiling reveals that nearly 20% of mitochondrial proteins in human cells are imported during translation on cytosolic ribosomes. Cotranslational import requires an N-terminal pres...
www.cell.com
4 9