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EMBO Molecular Medicine @embomolmed.org · 2d

#AI -identified #CD133 -targeting natural compounds demonstrate differential anti-tumor effects and mechanisms in pan-cancer models

By Y. Hou, Z. Wang, W. Wang, Y. Zhang, X. Dai, S. Ma & colleagues

🗞️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · 2d

A neuroprotective tetrapeptide for treatment of #AcuteTraumaticBrainInjury

By A. Mann, S. Hussain, E. Ruoslahti & colleagues @sbpdiscovery.bsky.social

➡️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · 9d

Complete attenuation of #PlasmodiumFalciparum sporozoites by atovaquone–proguanil 👉 doi.org/10.1038/s443...

By S Borrmann, Z Sulyok, K Müller, R Fendel, S Hoffman, P Kremsner, K Matuschewski, B Mordmüller & colleagues

Read also related N&V by G Rochfort Peters & J Baum 👉 doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · 9d

New method ➡️ Domain-substituted IGF2 tag modulates targeting of lentiviral #GeneTherapy for #HunterSyndrome

By F. Catalano, WWMP Pijnappel & colleagues @erasmusmc.bsky.social

🗞️ doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · 15d

📣 Metabolic #cardiomyopathies: untangling clinical heterogeneity with human #StemCell derived models

By A. Passadouro, @rhhoutkooper.bsky.social, S. Mosegaard & colleagues at University of Amsterdam

➡️ doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · 19d

Impaired migration and #LungInvasion of human #melanoma by a novel small molecule targeting the transmembrane domain of death receptor #p75NTR

by V. Lopes-Rodrigues, C. Ibanez & colleagues

doi.org/10.1038/s443...

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Reposted by EMBO Molecular Medicine

EMBO Molecular Medicine @embomolmed.org · 22d

Bead-based plasma #proteomics workflows boost proteome coverage but are vulnerable to cellular contamination, highlighting the need for contamination-aware quality control in #biomarker discovery.

K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social

🗞️ doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · 19d

Glycans on non-structural protein 1 prevent premature #Tcell mediated #DengueVirus clearance

By F. Idris, S. Alonso & colleagues at National Centre for Infectious Diseases Singapore

🗞️ doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · 22d

Dietary supplementation of #ArachidonicAcid promotes #HumoralImmunity

By. S. Feng, E. Ma, X. Na, Z. Wang, L. Zhao, A. Zhao, G. Cheng & colleagues at Tsinghua University

➡️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · 22d

Bead-based plasma #proteomics workflows boost proteome coverage but are vulnerable to cellular contamination, highlighting the need for contamination-aware quality control in #biomarker discovery.

K. Korff, M. Mann, P. Geyer & colleagues @mpibiochem.bsky.social

🗞️ doi.org/10.1038/s443...

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EMBO Molecular Medicine @embomolmed.org · 27d

Anti-M1R/B6R antibody characterization & bispecific design for enhanced #orthopoxvirus protection.

🗞 doi.org/10.1038/s443...

by R. Zhao, L. Wu, Y. Zhang, J. Ma, J. Xue, Q. Wang & colleagues at Chinese Academy of Medical Sciences

EMBO Molecular Medicine @embomolmed.org · 27d

CETN3 deficiency induces #microcephaly by disrupting neural stem/progenitor cell fate through impaired #CentrosomeAssembly and #RNAsplicing 👉 doi.org/10.1038/s443...

by J. Xu, X. Mao, Z. Liu, H. Wang, Z. Guo, S. Bian & colleagues at Tongji University & Changsha University

EMBO Molecular Medicine @embomolmed.org · 27d

Our September issue is online! www.embopress.org/toc/17574684...

On the cover: AAV-mediated delivery of Clic5 restores inner ear structure & function in a model of hereditary hearing and balance loss 👉 doi.org/10.1038/s443...

Scientific image: R. Hahn & K. Avraham, at Tel Aviv University

EMBO Molecular Medicine: Vol 17, No 9

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

www.embopress.org

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EMBO Molecular Medicine @embomolmed.org · 28d

Identification of #p38 MAPK inhibition as a neuroprotective strategy for combinatorial #SpinalMuscularAtrophy therapy

By M. Carlini, L. Pellizzoni & colleagues @columbiauniversity.bsky.social

➡️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · 28d

Novel #Zika vaccine platform designed by disrupting viral #RNATertiaryStructure achieves tissue-specific attenuation & protection, reducing vertical transmission in animal models.

X. Chen, ML Cheng, XY Huang, MX Sun, RT Li, CF Qin at Chinese Academy of Medical Sciences

doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · 28d

#TET3 is a regulator and can be targeted for the intervention of #MyocardialFibrosis

By C. Zhu, W. Hong, Y. Zhu, D. Jiang, Y. Xu, M. Kong and colleagues at Nanjing Medical University

🗞️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · Sep 8

New study by K. Avraham & colleagues ➡️ AAV #GeneTherapy rescues #hearing and #balance in a model of CLIC5 deafness

🗞️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · Sep 8

EMT-ciliary signaling in quasi-mesenchymal-stem-like cells drives #TherapeuticResistance & is a druggable vulnerability in #TNBC

By C Tessier, J Derrien, V Guen & al @inserm.fr @cnrs.fr

🗞️ doi.org/10.1038/s443...

👉N&V by AP Morel and @mariaouzounova.bsky.social
doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · Sep 8

Pyrin #inflammasome -driven #ErosiveArthritis caused by unprenylated RHO GTPase signaling

By M. Akula, G. van Loo & colleagues at VIB Ghent

🗞️ doi.org/10.1038/s443...

EMBO Molecular Medicine @embomolmed.org · Sep 3

🎉Congratulations to Yibing Wang at Inst Genet Dev Biol, Beijing, for winning the @embomolmed.org poster award at #OsakaMito2025!

Reposted by EMBO Molecular Medicine

Biomedical Picture of the Day BPoD @bpodaily.bsky.social · Sep 2

CMG2 (alias the anthrax toxin receptor) on gut cells is vital for replenishing intestinal stem cells – insights into genetic disorder hyaline fibromatosis syndrome

📷 Lucie Bracq et al EPFL (Swiss Federal Technology Institute of Lausanne) in @embomolmed.org

➡️ bpod.org.uk/archive/2025...

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Reposted by EMBO Molecular Medicine

dshb-antibodies.bsky.social @dshb-antibodies.bsky.social · Aug 14

🔎 Spotted in @embomolmed.org!
Researchers from #KyotoUniversity, among others, used DSHB's anti-PAX7 mAb in a study on miR-33 inhibition in muscular dystrophy, revealing increased satellite cell activity and better muscle recovery.

📄 tinyurl.com/4vv6z783

🧫 dshb.biology.uiowa.edu/PAX7

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EMBO Molecular Medicine @embomolmed.org · Aug 12

Don’t miss the article by A. Caplan, F. Pasadyn and N. Mamo published in this issue of @emboreports.org ➡️
"Fool’s-gold science: The ethical and scientific perils of testing most #vaccines using placebo-controlled randomized trials"

🗞️ doi.org/10.1038/s443...

Fool’s-gold science: The ethical and scientific perils of testing most vaccines using placebo-controlled randomized trials: EMBO reports: Vol 0, No 0

EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.

doi.org

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Reposted by EMBO Molecular Medicine

Stephen Graham's Lab @atomicvirology.bsky.social · Aug 11

Now published in @embomolmed.org 🥳🎉
Protein-based tools for detection and characterisation of #Oropouche virus infection...
See the final paper at doi.org/10.1038/s443... and read the bluetorial 👇

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