Eoghan Harrington
@eogh.bsky.social
Reposted by Eoghan Harrington
During my PhD @borklab.bsky.social, we extracted drug side effect data from package inserts and used the dataset to predict new drug targets (doi.org/10.1126/scie...) and pinpoint proteins that mediate the side effects (doi.org/10.1038/msb....). We also published the underlying database... [1/3]
Drug Target Identification Using Side-Effect Similarity
Targets for drugs have so far been predicted on the basis of molecular or cellular features, for example, by exploiting similarity in chemical structure or in activity across cell lines. We used pheno...
doi.org
December 11, 2025 at 6:49 PM
During my PhD @borklab.bsky.social, we extracted drug side effect data from package inserts and used the dataset to predict new drug targets (doi.org/10.1126/scie...) and pinpoint proteins that mediate the side effects (doi.org/10.1038/msb....). We also published the underlying database... [1/3]
Reposted by Eoghan Harrington
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
Accurate repair of DNA double-strand breaks (DSBs) is essential for genome stability, and defective repair underlies diseases such as cancer. Homologous recombination uses an intact homologous sequenc...
www.science.org
December 4, 2025 at 8:18 PM
I am happy to share that my postdoctoral work in the @gerlichlab.bsky.social at @imbavienna.bsky.social is finally out 🎉!
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Our study reveals how cohesin guides focused and accurate homology search.
Read more 👉 www.science.org/doi/10.1126/...
Follow along for key insights and updates! 🧵
Reposted by Eoghan Harrington
So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this!
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
Combinatorial BMP4 and activin direct the choice between alternate routes to endoderm in a stem cell model of human gastrulation
Inge et al. show that human endoderm originates from two converging developmental
routes with distinct dynamics and efficiencies yet similar developmental potential.
Combinatorial activin and BMP4 sig...
www.cell.com
December 2, 2025 at 1:47 PM
So exciting to see this in print! Ever wondered how embryonic cells know what (fate) to become during early development? In particular when they might see different signaling cues? We investigated this!
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
And a lovely cover from Zoe Ruiz and @oliveringe.bsky.social!
www.cell.com/developmenta...
Reposted by Eoghan Harrington
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
POSTDOCTORAL FELLOW - Toronto (City), Ontario (CA) job with Taipale Lab, Donnelly Centre, University of Toronto | 12849004
The Taipale lab in the Donnelly CCBR and University of Toronto is looking for a highly motivated Postdoctoral Fellow
www.nature.com
November 19, 2025 at 5:51 PM
We are looking for a postdoctoral fellow to work on induced proximity 🤜🤛 and functional genomics! Join our team in Toronto 🇨🇦 to tackle major challenges in oncology and neurodegeneration. www.nature.com/naturecareer...
Reposted by Eoghan Harrington
I decided to experiment with my own (small) protein design competition!
It's specifically to test how well VHH pipelines work for binder design, without the usual careful tuning.
You submit a modal script, I run it and test on benchbb.bio
blog.booleanbiotech.com/vhh-competit...
It's specifically to test how well VHH pipelines work for binder design, without the usual careful tuning.
You submit a modal script, I run it and test on benchbb.bio
blog.booleanbiotech.com/vhh-competit...
October 16, 2025 at 4:54 PM
I decided to experiment with my own (small) protein design competition!
It's specifically to test how well VHH pipelines work for binder design, without the usual careful tuning.
You submit a modal script, I run it and test on benchbb.bio
blog.booleanbiotech.com/vhh-competit...
It's specifically to test how well VHH pipelines work for binder design, without the usual careful tuning.
You submit a modal script, I run it and test on benchbb.bio
blog.booleanbiotech.com/vhh-competit...
Reposted by Eoghan Harrington
New blogpost on the latest in AI antibody design.
Including some code to easily run Germinal and IgGM on modal!
blog.booleanbiotech.com/ai-antibody-...
Including some code to easily run Germinal and IgGM on modal!
blog.booleanbiotech.com/ai-antibody-...
Boolean Biotech
blog.booleanbiotech.com
September 28, 2025 at 2:25 PM
New blogpost on the latest in AI antibody design.
Including some code to easily run Germinal and IgGM on modal!
blog.booleanbiotech.com/ai-antibody-...
Including some code to easily run Germinal and IgGM on modal!
blog.booleanbiotech.com/ai-antibody-...
Reposted by Eoghan Harrington
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Group Leader - Genome Biology Unit
Are you ready to lead groundbreaking research in Genome Biology? Join us at EMBL! We are seeking a motivated scientist to lead an independent research group addressing exciting and original biological...
embl.wd103.myworkdayjobs.com
July 30, 2025 at 1:41 PM
To all post-docs: The Genome Biology dept @embl.org
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
has an Independent faculty position. Fantastic place to set up your lab –great package: core funding, fantastic Ph.D. students, cutting edge core facilities & great colleagues. Closing date Sept 19th
embl.wd103.myworkdayjobs.com/en-US/EMBL/j...
Looking for your next challenge? Come join us at Decade
After many months heads down, we at Decade are growing! We are hiring a protein biochemist to help us radically improve cancer treatment.
If you like being early and making an impact, we are interested to hear from you! Details here: decade.bio/careers
If you like being early and making an impact, we are interested to hear from you! Details here: decade.bio/careers
decade.bio
July 26, 2025 at 1:26 AM
Looking for your next challenge? Come join us at Decade
Reposted by Eoghan Harrington
After many months heads down, we at Decade are growing! We are hiring a protein biochemist to help us radically improve cancer treatment.
If you like being early and making an impact, we are interested to hear from you! Details here: decade.bio/careers
If you like being early and making an impact, we are interested to hear from you! Details here: decade.bio/careers
decade.bio
July 25, 2025 at 8:23 PM
After many months heads down, we at Decade are growing! We are hiring a protein biochemist to help us radically improve cancer treatment.
If you like being early and making an impact, we are interested to hear from you! Details here: decade.bio/careers
If you like being early and making an impact, we are interested to hear from you! Details here: decade.bio/careers
Reposted by Eoghan Harrington
The biggest challenge for AI in biology isn't just models, it's the data used to train them. Standard biological data isn't built for AI. To unlock generative AI for drug discovery, we must rethink how we generate and capture data. 1/
July 22, 2025 at 12:30 PM
The biggest challenge for AI in biology isn't just models, it's the data used to train them. Standard biological data isn't built for AI. To unlock generative AI for drug discovery, we must rethink how we generate and capture data. 1/
Reposted by Eoghan Harrington
We're hiring a postdoc!🚨
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics data analysis
- Micro & molecular bio techniques are a plus!
Apply now!🌟
jobs.vib.be/j/119682/pos...
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics data analysis
- Micro & molecular bio techniques are a plus!
Apply now!🌟
jobs.vib.be/j/119682/pos...
Postdoctoral position in human gut microbiome and bioinformatics - VIB
About the Lab
Thelab of JeroenRaes(VIB, KU Leuven) is home to a vibrant, dynamic and international group of researchers in the field of gut microbial ecology and its
jobs.vib.be
July 23, 2025 at 6:43 AM
We're hiring a postdoc!🚨
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics data analysis
- Micro & molecular bio techniques are a plus!
Apply now!🌟
jobs.vib.be/j/119682/pos...
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics data analysis
- Micro & molecular bio techniques are a plus!
Apply now!🌟
jobs.vib.be/j/119682/pos...
Reposted by Eoghan Harrington
A little interview with my postdoctoral advisor Jim Ferrell about his life. Timely as we prepare to celebrate his 70th birthday with a Ferrell -Lab-family symposium
youtu.be/ov9YMkmzUAg?...
youtu.be/ov9YMkmzUAg?...
"Living Histories". James Ferrell | #TheLivingHistoriesSeries
YouTube video by The Living Histories Series
youtu.be
June 30, 2025 at 7:23 AM
A little interview with my postdoctoral advisor Jim Ferrell about his life. Timely as we prepare to celebrate his 70th birthday with a Ferrell -Lab-family symposium
youtu.be/ov9YMkmzUAg?...
youtu.be/ov9YMkmzUAg?...
Reposted by Eoghan Harrington
Thrilled to announce that I am joining DTU in Copenhagen in the fall, as an assistant professor of chemistry.
My research group will focus on fundamental methodology in machine learning for molecules.
My research group will focus on fundamental methodology in machine learning for molecules.
May 29, 2025 at 5:04 PM
Thrilled to announce that I am joining DTU in Copenhagen in the fall, as an assistant professor of chemistry.
My research group will focus on fundamental methodology in machine learning for molecules.
My research group will focus on fundamental methodology in machine learning for molecules.
Reposted by Eoghan Harrington
If there's such a thing as AI for drug design & development on easy mode, then it's probably in being able to build and test every design.
Check out our journey to the 10 quadrillion AI-designed antibody library now; we're going to be sharing some big updates soon:
▶️ www.jura.bio/blog/variati...
Check out our journey to the 10 quadrillion AI-designed antibody library now; we're going to be sharing some big updates soon:
▶️ www.jura.bio/blog/variati...
May 21, 2025 at 5:55 PM
If there's such a thing as AI for drug design & development on easy mode, then it's probably in being able to build and test every design.
Check out our journey to the 10 quadrillion AI-designed antibody library now; we're going to be sharing some big updates soon:
▶️ www.jura.bio/blog/variati...
Check out our journey to the 10 quadrillion AI-designed antibody library now; we're going to be sharing some big updates soon:
▶️ www.jura.bio/blog/variati...
Reposted by Eoghan Harrington
We have gotten some really good responses to science questions from platform.futurehouse.org already. Both from "Crow" (short answers) and "Falcon" (deep research).
It looks like this is state of the art right now!
It looks like this is state of the art right now!
May 2, 2025 at 10:03 PM
We have gotten some really good responses to science questions from platform.futurehouse.org already. Both from "Crow" (short answers) and "Falcon" (deep research).
It looks like this is state of the art right now!
It looks like this is state of the art right now!
Reposted by Eoghan Harrington
Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
A tissue-specific atlas of protein–protein associations enables prioritization of candidate disease genes - Nature Biotechnology
Protein–protein interactions specific to 11 individual tissues are presented in a comprehensive resource.
www.nature.com
May 2, 2025 at 10:31 AM
Our work on deriving protein-protein (functional) associations across different human tissues from proteomics data is now published. There is quite a lot in this paper, so I will just touch on a few highlights:
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Eoghan Harrington
EMBL has a single PhD application where a student can apply to any of our 80 labs in our 6 sites, with applications twice a year--the next March 10th! No need for MS, no application fee. Ranked 13th in the world on basis of publications, with emphais on junior faculty
www.embl.org/about/info/e...
www.embl.org/about/info/e...
EMBL International PhD Programme – Unique in the world and waiting for you!
www.embl.org
March 1, 2025 at 12:29 PM
EMBL has a single PhD application where a student can apply to any of our 80 labs in our 6 sites, with applications twice a year--the next March 10th! No need for MS, no application fee. Ranked 13th in the world on basis of publications, with emphais on junior faculty
www.embl.org/about/info/e...
www.embl.org/about/info/e...
Reposted by Eoghan Harrington
We're hiring a postdoc!🚨
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics
- Strong publication record
Apply now!🌟 jobs.vib.be/j/69697/post...
@vibmicrobes.bsky.social
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics
- Strong publication record
Apply now!🌟 jobs.vib.be/j/69697/post...
@vibmicrobes.bsky.social
Postdoctoral position in bioinformatics of the human gut microbiome - VIB
About the Lab
Thelab of JeroenRaes(VIB, KU Leuven) is home to a vibrant, dynamic and international group of researchers in the field of gut microbial ecology and its clinical applications
jobs.vib.be
February 20, 2025 at 7:53 AM
We're hiring a postdoc!🚨
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics
- Strong publication record
Apply now!🌟 jobs.vib.be/j/69697/post...
@vibmicrobes.bsky.social
Study human-associated microbial communities in health & disease.
🔬Requirements:
- PhD in bioinformatics, microbiology, or related field
- Expertise in omics
- Strong publication record
Apply now!🌟 jobs.vib.be/j/69697/post...
@vibmicrobes.bsky.social
Reposted by Eoghan Harrington
Check out our new Apps Note on metagenomic assembly of the Zymo fecal reference with nanopore sequencing and metaMDBG. Almost 200 Gb of metagenomic sequence data from a single PromethION flowcell, yeilding hundreds of high-quality metagenome assembled genomes: nanoporetech.com/resource-cen...
Application note: Oxford Nanopore sequencing provides superior MAG recovery and strain-level resolution from a complex microbiome | Oxford Nanopore Technologies
In this application note, we demonstrate the
capabilities of Oxford Nanopore metagenomics by
sequencing and analysing the well-characterised
ZymoBIOMICS Fecal Reference.
nanoporetech.com
December 19, 2024 at 5:55 PM
Check out our new Apps Note on metagenomic assembly of the Zymo fecal reference with nanopore sequencing and metaMDBG. Almost 200 Gb of metagenomic sequence data from a single PromethION flowcell, yeilding hundreds of high-quality metagenome assembled genomes: nanoporetech.com/resource-cen...
Reposted by Eoghan Harrington
We had shown that network propagation of trait associated genes can identify related traits based on GWAS data. With the Bachmann-Gagescu lab we (Ellen Aarts) tested the same concept on a family of rare disorders (ciliopathies) and their related mouse phenotypes www.biorxiv.org/content/10.1...
Network-based framework for studying etiology and phenotype diversity in primary ciliopathies
Recent advances in sequencing technologies have increasingly enabled the identification of genetic causes for human monogenic diseases. However, systematic understanding remains limited due to the rar...
www.biorxiv.org
January 9, 2025 at 11:00 AM
We had shown that network propagation of trait associated genes can identify related traits based on GWAS data. With the Bachmann-Gagescu lab we (Ellen Aarts) tested the same concept on a family of rare disorders (ciliopathies) and their related mouse phenotypes www.biorxiv.org/content/10.1...
Reposted by Eoghan Harrington
🚨 We're hiring a postdoc! 🚨
Study human-associated microbial communities in health & disease.
🔬 Requirements:
PhD in bioinformatics, microbiology, or related field
Expertise in omics
Strong publication record
jobs.vib.be/j/69697/post...
Apply now! 🌟 @vibmicrobes.bsky.social
Study human-associated microbial communities in health & disease.
🔬 Requirements:
PhD in bioinformatics, microbiology, or related field
Expertise in omics
Strong publication record
jobs.vib.be/j/69697/post...
Apply now! 🌟 @vibmicrobes.bsky.social
Postdoctoral position in bioinformatics of the human gut microbiome - VIB
About the Lab
Thelab of JeroenRaes(VIB, KU Leuven) is home to a vibrant, dynamic and international group of researchers in the field of gut microbial ecology and its clinical applications
jobs.vib.be
December 24, 2024 at 10:06 AM
🚨 We're hiring a postdoc! 🚨
Study human-associated microbial communities in health & disease.
🔬 Requirements:
PhD in bioinformatics, microbiology, or related field
Expertise in omics
Strong publication record
jobs.vib.be/j/69697/post...
Apply now! 🌟 @vibmicrobes.bsky.social
Study human-associated microbial communities in health & disease.
🔬 Requirements:
PhD in bioinformatics, microbiology, or related field
Expertise in omics
Strong publication record
jobs.vib.be/j/69697/post...
Apply now! 🌟 @vibmicrobes.bsky.social
Reposted by Eoghan Harrington
Reposted by Eoghan Harrington
We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them.
Read more: nanoporetech.com/news/oxford-...
Read more: nanoporetech.com/news/oxford-...
November 27, 2024 at 9:16 AM
We are proud to announce a collaboration with UK Biobank to create the world’s first large-scale #epigenetic dataset of 50k participants. The dataset will unlock crucial insights into how #epigenetics drives disease & the breakthroughs to treat them.
Read more: nanoporetech.com/news/oxford-...
Read more: nanoporetech.com/news/oxford-...
Reposted by Eoghan Harrington
Booting up bluesky again!
Blogpost on the Adaptyv protein design competition: blog.booleanbiotech.com/adaptyv-bind...
Blogpost on the Adaptyv protein design competition: blog.booleanbiotech.com/adaptyv-bind...
Boolean Biotech
blog.booleanbiotech.com
September 17, 2024 at 8:08 PM
Booting up bluesky again!
Blogpost on the Adaptyv protein design competition: blog.booleanbiotech.com/adaptyv-bind...
Blogpost on the Adaptyv protein design competition: blog.booleanbiotech.com/adaptyv-bind...