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Michael Epstein @epsteinstatgen.bsky.social · 8d

I was told Commons will remain operational….but no IT help if things go screwy

Reposted by Michael Epstein

Haky Im @hakyim.bsky.social · 26d

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

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Reposted by Michael Epstein

Andrew Bass @ajbass.bsky.social · Aug 25

Excited to see our (w/ @chr1sw.bsky.social) work published in @natcomputsci.nature.com! We developed a new framework, surrogate functional false discovery rate (sffdr), that integrates summary statistics of related traits to improve power in GWASs.

Paper: www.nature.com/articles/s43...

Exploiting pleiotropy to enhance variant discovery with functional false discovery rates - Nature Computational Science

This study introduces a cost-effective strategy called surrogate functional false discovery rates to increase power in genome-wide association studies by leveraging genetic correlations (or pleiotropy...

www.nature.com

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Michael Epstein @epsteinstatgen.bsky.social · Jul 22

RIP, Prince of Darkness. Arguably in the Top 5 of most influential artists of my lifetime

Dave Itzkoff @ditzkoff.bsky.social · Jul 22

I truly thought this man was going to live forever, somehow. RIP, Ozzy, you were metal incarnate for me. news.sky.com/story/ozzy-o...

Ozzy Osbourne dies just weeks after farewell show

The heavy metal star reunited with his Black Sabbath bandmates on stage at Villa Park earlier in July.

news.sky.com

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Michael Epstein @epsteinstatgen.bsky.social · Jun 23

Our new AJHG paper is online. We develop a new TWAS tool that uses local-ancestry information to improve power of gene mapping in admixed samples. Lead author Taylor Head (now at MD Anderson) did a phenomenal job spearheading this work!

The American Journal of Human Genetics @ajhgnews.bsky.social · Jun 20

🚨New method!
📄CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data
🧑‍🤝‍🧑 @epsteinstatgen.bsky.social @yjingj.bsky.social & co

CADET: Enhanced transcriptome-wide association analyses in admixed samples using eQTL summary data

CADET is a transcriptome-wide association test for admixed cohorts that leverages local ancestry information to improve detection of trait-influencing genes. CADET outperformed existing methods using ...

www.cell.com

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Michael Epstein @epsteinstatgen.bsky.social · Jun 15

Are the Falcons really going to keep Kirk as the backup?

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Michael Epstein @epsteinstatgen.bsky.social · Apr 24

Think they would make a play for Trae Young if he becomes available?

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Reposted by Michael Epstein

Sasha Gusev @sashagusevposts.bsky.social · Apr 19

Incredible GRC Genetics and Genomics conference line-up this year in Portland, Maine (www.grc.org/human-geneti...). With conference-maxxing sessions that run to 9:30pm!

Submission deadline is June 8th, conference July 6-11th.

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Reposted by Michael Epstein

Bjarni Vilhjalmsson @bvilhjal.bsky.social · Mar 25

Multiple Postdoc Positions available in Epidemiology, Biostatistics, or Statistical Genetics (deadline April 15)

Join an International team at the Pioneer Centre for SMARTbiomed, Aarhus, Denmark!
#Postdoc #Epidemiology #StatisticalGenetics #Biostatistics

👉 international.au.dk/about/profil...

Postdocs in Epidemiology or Statistical Genetics at The Pioneer Centre for SMARTbiomed - Vacancy at Aarhus University

Vacancy at Department of Public Health - NCRR - National Centre for Register-based Research, Aarhus University

international.au.dk

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Michael Epstein @epsteinstatgen.bsky.social · Mar 15

One of my students once caught me in my office air drumming to Limelight. I regret nothing

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Michael Epstein @epsteinstatgen.bsky.social · Mar 15

Welcome to the team!!!!

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Michael Epstein @epsteinstatgen.bsky.social · Mar 5

You feel old? I wrote my first dissertation paper listening to that album

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Michael Epstein @epsteinstatgen.bsky.social · Feb 9

The new NIH cap on indirect costs for federal grants awarded to universities will have a devastating effect on medical services provided by many hospitals and will likely spike college tuition as well. Any chance Congress pushes back on this?

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Michael Epstein @epsteinstatgen.bsky.social · Jan 15

Congrats! Well deserved!

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Reposted by Michael Epstein

Julia Métraux @juliametraux.bsky.social · Dec 25

Happy Chrismukkah to all the delightful half-half situations (like me)

Stills from the show Schitt's Creek in a shop. One character, a white man asks, "Do I not get a Merry Christmas?" A woman, who is also white, responds, "I thought you were Jewish." He responds back, "I'm a delightful half-half situation."

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Reposted by Michael Epstein

Austin Kocher, PhD @austinkocher.com · Dec 15

Accurate.

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Michael Epstein @epsteinstatgen.bsky.social · Dec 4

For those working in pathway and co-expression analysis, check out Andy’s recent preprint describing a more powerful and flexible framework for such studies!

Andrew Bass @ajbass.bsky.social · Dec 4

Differential co-expression arises from shared unmodeled biological variation involving an observed risk factor and an unobserved (or latent) factor. We developed a method to detect such variation in a pathway for general gene expression studies!

bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · Dec 3

A powerful framework for differential co-expression analysis of general risk factors https://www.biorxiv.org/content/10.1101/2024.11.29.626006v1

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Reposted by Michael Epstein

MattBloodMD @doctorblood.bsky.social · Nov 29

We humbly thank the reviewers for their suggestions. We would like to resubmit this improved manuscript for your consideration. #AcademicSky #MedSky

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Reposted by Michael Epstein

Josh Weinstock @joshweinstock.bsky.social · Nov 22

I'm developing a pipeline to call CHIP mutations in UK Biobank using the DNA Nexus RAP that is fast/cheap/reproducible. Initial results are promising; calls looks reasonable and cost to do this across all of UKB is likely < 500$.

Feel free to DM if of interest.

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Reposted by Michael Epstein

Matthew L Reznicek @drreznicek.bsky.social · Aug 6

Finally a VP who’s had to design a syllabus!

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Michael Epstein @epsteinstatgen.bsky.social · Jul 6

Did you enjoy your prep school experience? Would you recommend it to others?

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Michael Epstein @epsteinstatgen.bsky.social · May 1

Excited to share our method LIT; a kernel approach to map genetic variants with interaction effects on multiple phenotypes in biobanks. R package implementing the method available on CRAN. Kudos to Andy Bass for leading this work!

genomemedicine.biomedcentral.com/articles/10....

Identifying latent genetic interactions in genome-wide association studies using multiple traits - Genome Medicine

The "missing" heritability of complex traits may be partly explained by genetic variants interacting with other genes or environments that are difficult to specify, observe, and detect. We propose a n...

genomemedicine.biomedcentral.com

Michael Epstein @epsteinstatgen.bsky.social · Feb 22

Best and worst football movie?

Michael Epstein @epsteinstatgen.bsky.social · Jan 28

Paul Giamatti did a wonderful job exemplifying so many of the instructors I had in prep school. Massive flashbacks

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Michael Epstein @epsteinstatgen.bsky.social · Dec 17

You are put in charge of NFL stadium music at US Bank. Do you keep the old Metallica/GnR/Queen staples or do you inject new blood? If the latter, what do you go with?

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