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Haky Im @hakyim.bsky.social · 26d

I'm hiring a computational biologist interested in complex trait genetics using deep learning approaches. Reach out to me, if interested.

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Haky Im @hakyim.bsky.social · May 14

Check out our scPrediXcan paper
www.cell.com/cell-genomic...
Led by the talented @Charles_Zhou12 and supervised by @MengjieChen6
and me, with thanks to many contributors.

scPrediXcan integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework.

scPrediXcan integrates deep learning methods and single-cell data into a cell-type-specific transcriptome-wide association study framework

Zhou et al. introduce scPrediXcan, a novel transcriptome-wide association study framework that integrates the deep learning-based model ctPred for cell-type-specific expression prediction. Applied to ...

www.cell.com

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Haky Im @hakyim.bsky.social · Feb 14

Need a break from doomscrolling?

Do you study the genetics of disease subtypes? Have you ever wondered how to efficiently run gene-based associations with multicategorical outcomes? Join us for the IGES Journal Club on Wednesday, February 26, 2025! 11AM ET.

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Haky Im @hakyim.bsky.social · Feb 11

Ughhh, suffering the plos system now. My collaborators won’t let me submit future papers to PLoS

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Reposted by Haky Im

Jonathan Pritchard @jkpritch.bsky.social · Jan 26

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?

I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

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Reposted by Haky Im

Mike-ghoul Half-man @michaelhoffman.bsky.social · Jun 11

1/At the #HoffmanLab lab meeting, we often have tech talks describing useful tools for other lab members. Since they might also prove useful for others, we've been posting almost every #HoffmanLabTechTalk for years. 🧪🧬💻

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Haky Im @hakyim.bsky.social · Nov 15

with invaluable contributions from @temicrates Lisha Zhu @ssalazar_02 Sarah Sumner Hyunki Kim Saideep Gona @Festus_nyasimi Rohit Kulkarni @drjosephpowell @madduri
@boxiangliu

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Haky Im @hakyim.bsky.social · Nov 15

check out our new preprint led by Charles Zhou and supervised by Mengjie Chen and me doi.org/10.1101/2024... where we present scPrediXcan which integrates deep learning and single cell expression data into a powerful cell type specific TWAS framework

scPrediXcan integrates advances in deep learning and single-cell data into a powerful cell-type–specific transcriptome-wide association study framework

Transcriptome-wide association studies (TWAS) help identify disease causing genes, but often fail to pinpoint disease mechanisms at the cellular level because of the limited sample sizes and sparsity ...

doi.org

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Haky Im @hakyim.bsky.social · Nov 13

Consistency is key

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Haky Im @hakyim.bsky.social · Nov 13

I’m at UChicago, develop methods to understand the biology of complex trait and diseases, aspire to help real people with my research. Currently very optimistic about predicting molecular traits from DNA sequences using m/billions of parameters

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Reposted by Haky Im

🇲🇽 Leonardo Collado-Torres @lcolladotor.bsky.social · Nov 11

🆕 Blog: Genomics scientists from and in Mexico community building lcolladotor.github.io/2024/11/11/g...

I want our voices🇲🇽 to be heard from the scientific community. But to be heard, we have to be a part of it

#LCG-UNAM #LCG-EJ-UNAM @cdsbmexico.bsky.social #NNB-UNAM #RMB

youtu.be/OVMw0k6AydA?...

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Reposted by Haky Im

Dr Abeba Birhane @abeba.bsky.social · Jul 16

Peter Buxtun, the whistleblower who revealed that the U.S. government allowed hundreds of Black men in rural Alabama to go untreated for syphilis in what became known as the Tuskegee study, has died. He was 86. apnews.com/article/buxt...

Tuskegee syphilis study whistleblower Peter Buxtun has died at age 86

The whistleblower who exposed the Tuskegee syphilis study that left hundreds of Black men untreated has died at age 86.

apnews.com

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Haky Im @hakyim.bsky.social · Apr 18

IGES (international genetic epidemiology society) journal club recording "The All of Us Research Program: Data Resources and Access"; by Dr. Anji Musick is available here:

drive.google.com/file/d/1bty6...

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Reposted by Haky Im

Anne Carpenter @drannecarpenter.bsky.social · Nov 5

Also worth noting: the US NIH offers financial support for those from ANY underrepresented group at ANY career stage to join an NIH funded lab!

Find a professor whose research you’re interested in and see if they are willing to host you! grants.nih.gov/grants/guide...

PA-23-189: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Research Supplements to Promote Diversity in Health-Related Research (Admin Supp Clinical Trial Not Allowed) PA-23-189....

grants.nih.gov

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Haky Im @hakyim.bsky.social · Oct 23

TWAS (transcriptome wide association study) is a statistical method that prioritizes genes that are more likely to cause a disease. It uses GWAS (genome wide association study) data, which is a method that identifies genomic loci associated with diseases

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Haky Im @hakyim.bsky.social · Oct 21

Preprint is up now www.biorxiv.org/content/10.1...

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